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USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1.

Zhang X, Berger FG, Yang J, Lu X.

EMBO J. 2011 Jun 1;30(11):2177-89. doi: 10.1038/emboj.2011.125. Epub 2011 Apr 26.


ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.

Chen D, Kon N, Li M, Zhang W, Qin J, Gu W.

Cell. 2005 Jul 1;121(7):1071-83.


Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase.

Xu C, Fan CD, Wang X.

Oncogene. 2015 Jan 15;34(3):281-9. doi: 10.1038/onc.2013.557. Epub 2014 Jan 13.


Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.

Kon N, Zhong J, Qiang L, Accili D, Gu W.

J Biol Chem. 2012 Feb 10;287(7):5102-11. doi: 10.1074/jbc.M111.322867. Epub 2011 Dec 20.


Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms.

Qi CF, Kim YS, Xiang S, Abdullaev Z, Torrey TA, Janz S, Kovalchuk AL, Sun J, Chen D, Cho WC, Gu W, Morse HC 3rd.

Int J Mol Sci. 2012;13(5):6204-19. doi: 10.3390/ijms13056204. Epub 2012 May 21.


p53 ubiquitination: Mdm2 and beyond.

Brooks CL, Gu W.

Mol Cell. 2006 Feb 3;21(3):307-15. Review.


Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells.

Duan W, Gao L, Wu X, Zhang Y, Otterson GA, Villalona-Calero MA.

Exp Cell Res. 2006 Oct 15;312(17):3370-8. Epub 2006 Jul 21.


Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53.

Wang L, He G, Zhang P, Wang X, Jiang M, Yu L.

Mol Biol Rep. 2011 Jan;38(1):229-36. doi: 10.1007/s11033-010-0099-x. Epub 2010 Mar 24.


USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.

Li Z, Hao Q, Luo J, Xiong J, Zhang S, Wang T, Bai L, Wang W, Chen M, Wang W, Gu L, Lv K, Chen J.

Oncogene. 2016 Jun 2;35(22):2902-12. doi: 10.1038/onc.2015.349. Epub 2015 Sep 28.


The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest.

Corcoran CA, Huang Y, Sheikh MS.

Cancer Biol Ther. 2004 Aug;3(8):721-5. Epub 2004 Aug 1.


Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.

Xing C, Lu XX, Guo PD, Shen T, Zhang S, He XS, Gan WJ, Li XM, Wang JR, Zhao YY, Wu H, Li JM.

Cancer Res. 2016 Jan 1;76(1):83-95. doi: 10.1158/0008-5472.CAN-14-3595. Epub 2015 Dec 15.


Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis.

Das A, Chendil D, Dey S, Mohiuddin M, Mohiuddin M, Milbrandt J, Rangnekar VM, Ahmed MM.

J Biol Chem. 2001 Feb 2;276(5):3279-86. Epub 2000 Oct 16.


The ubiquitin ligase COP1 is a critical negative regulator of p53.

Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O'Rourke K, Koeppen H, Dixit VM.

Nature. 2004 May 6;429(6987):86-92. Epub 2004 Apr 21.


Mouse models of Mdm2 and Mdm4 and their clinical implications.

Xiong S.

Chin J Cancer. 2013 Jul;32(7):371-5. doi: 10.5732/cjc.012.10286. Epub 2013 Jan 18. Review.


Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.

Kamijo T, van de Kamp E, Chong MJ, Zindy F, Diehl JA, Sherr CJ, McKinnon PJ.

Cancer Res. 1999 May 15;59(10):2464-9.


Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.

Inoue K, Wen R, Rehg JE, Adachi M, Cleveland JL, Roussel MF, Sherr CJ.

Genes Dev. 2000 Jul 15;14(14):1797-809.


Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme.

Soboleva TA, Jans DA, Johnson-Saliba M, Baker RT.

J Biol Chem. 2005 Jan 7;280(1):745-52. Epub 2004 Oct 18.


Oncogenic ras and p53 cooperate to induce cellular senescence.

Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW.

Mol Cell Biol. 2002 May;22(10):3497-508.

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