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Items: 1 to 20 of 94


Extracellular matrix proteases contribute to progression of pelvic organ prolapse in mice and humans.

Budatha M, Roshanravan S, Zheng Q, Weislander C, Chapman SL, Davis EC, Starcher B, Word RA, Yanagisawa H.

J Clin Invest. 2011 May;121(5):2048-59. doi: 10.1172/JCI45636. Epub 2011 Apr 25.


Effect of vaginal distention on elastic fiber synthesis and matrix degradation in the vaginal wall: potential role in the pathogenesis of pelvic organ prolapse.

Rahn DD, Acevedo JF, Word RA.

Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1351-8. doi: 10.1152/ajpregu.90447.2008. Epub 2008 Jul 16.


Pelvic Organ Support in Animals with Partial Loss of Fibulin-5 in the Vaginal Wall.

Chin K, Wieslander C, Shi H, Balgobin S, Montoya TI, Yanagisawa H, Word RA.

PLoS One. 2016 Apr 28;11(4):e0152793. doi: 10.1371/journal.pone.0152793. eCollection 2016.


Dysregulation of protease and protease inhibitors in a mouse model of human pelvic organ prolapse.

Budatha M, Silva S, Montoya TI, Suzuki A, Shah-Simpson S, Wieslander CK, Yanagisawa M, Word RA, Yanagisawa H.

PLoS One. 2013;8(2):e56376. doi: 10.1371/journal.pone.0056376. Epub 2013 Feb 20.


Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse.

Alarab M, Kufaishi H, Lye S, Drutz H, Shynlova O.

Reprod Sci. 2014 Jun;21(6):704-15. doi: 10.1177/1933719113512529. Epub 2013 Dec 16.


[Expression and significance of elastin and fibulin-5 in anterior vaginal tissue of women with pelvic organ prolapse].

Li B, Zhang QF, Lin XY, Chen LL, Ouyang L, Zhang SL.

Zhonghua Fu Chan Ke Za Zhi. 2009 Jul;44(7):514-7. Chinese.


Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina.

Drewes PG, Yanagisawa H, Starcher B, Hornstra I, Csiszar K, Marinis SI, Keller P, Word RA.

Am J Pathol. 2007 Feb;170(2):578-89.


Quantification of pelvic organ prolapse in mice: vaginal protease activity precedes increased MOPQ scores in fibulin 5 knockout mice.

Wieslander CK, Rahn DD, McIntire DD, Acevedo JF, Drewes PG, Yanagisawa H, Word RA.

Biol Reprod. 2009 Mar;80(3):407-14. doi: 10.1095/biolreprod.108.072900. Epub 2008 Nov 5.


Elastogenesis in the vaginal wall and pelvic-organ prolapse.

Connell KA.

N Engl J Med. 2011 Jun 16;364(24):2356-8. doi: 10.1056/NEJMcibr1104976. No abstract available.


Failure of pelvic organ support in mice deficient in fibulin-3.

Rahn DD, Acevedo JF, Roshanravan S, Keller PW, Davis EC, Marmorstein LY, Word RA.

Am J Pathol. 2009 Jan;174(1):206-15. doi: 10.2353/ajpath.2009.080212. Epub 2008 Dec 18.


Fibulin-5: two for the price of one maintaining pelvic support.

Northington GM.

J Clin Invest. 2011 May;121(5):1688-91. doi: 10.1172/JCI57438. Epub 2011 Apr 25.


Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content.

Ruiz-Zapata AM, Kerkhof MH, Ghazanfari S, Zandieh-Doulabi B, Stoop R, Smit TH, Helder MN.

Sci Rep. 2016 Mar 11;6:22971. doi: 10.1038/srep22971.


Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse.

Wang X, Li Y, Chen J, Guo X, Guan H, Li C.

Mol Med Rep. 2014 Oct;10(4):2004-8. doi: 10.3892/mmr.2014.2467. Epub 2014 Aug 8.


Thermosensitive hydrogels deliver bioactive protein to the vaginal wall.

Good MM, Montoya TI, Shi H, Zhou J, Huang Y, Tang L, Acevedo JF, Word RA.

PLoS One. 2017 Oct 26;12(10):e0186268. doi: 10.1371/journal.pone.0186268. eCollection 2017.


Functional characteristics of vaginal fibroblastic cells from premenopausal women with pelvic organ prolapse.

Ruiz-Zapata AM, Kerkhof MH, Zandieh-Doulabi B, Brölmann HA, Smit TH, Helder MN.

Mol Hum Reprod. 2014 Nov;20(11):1135-43. doi: 10.1093/molehr/gau078. Epub 2014 Sep 4.


Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.

Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O.

Reprod Sci. 2016 Jul;23(7):931-43. doi: 10.1177/1933719115625840. Epub 2016 Jan 13.


[Connective tissue and prolapse genesis].

Tremollieres F.

Gynecol Obstet Fertil. 2010 Jun;38(6):388-93. doi: 10.1016/j.gyobfe.2010.04.005. Epub 2010 Jun 4. Review. French.


Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse.

Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O.

Reprod Sci. 2016 Aug;23(8):978-92. doi: 10.1177/1933719115625844. Epub 2016 Jan 27.


Decreased expression of elastin, fibulin-5 and lysyl oxidase-like 1 in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse.

Zhao BH, Zhou JH.

J Obstet Gynaecol Res. 2012 Jun;38(6):925-31. doi: 10.1111/j.1447-0756.2011.01814.x. Epub 2012 Apr 9.


Transforming growth factor β1 and extracellular matrix protease expression in the uterosacral ligaments of patients with and without pelvic organ prolapse.

Leegant A, Zuckerwise LC, Downing K, Brouwer-Visser J, Zhu C, Cossio MJ, Strube F, Xie X, Banks E, Huang GS.

Female Pelvic Med Reconstr Surg. 2015 Jan-Feb;21(1):53-8. doi: 10.1097/SPV.0000000000000130.

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