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Items: 1 to 20 of 193

1.

A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos.

Vollmer LL, Jiménez M, Camarco DP, Zhu W, Daghestani HN, Balachandran R, Reese CE, Lazo JS, Hukriede NA, Curran DP, Day BW, Vogt A.

Mol Cancer Ther. 2011 Jun;10(6):994-1006. doi: 10.1158/1535-7163.MCT-10-1048. Epub 2011 Apr 13.

2.

Cell-based and biochemical structure-activity analyses of analogs of the microtubule stabilizer dictyostatin.

Raccor BS, Vogt A, Sikorski RP, Madiraju C, Balachandran R, Montgomery K, Shin Y, Fukui Y, Jung WH, Curran DP, Day BW.

Mol Pharmacol. 2008 Mar;73(3):718-26. Epub 2007 Dec 11.

3.

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW.

Biochemistry. 2005 Nov 15;44(45):15053-63.

PMID:
16274252
4.

Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.

Paterson I, Gardner NM, Poullennec KG, Wright AE.

J Nat Prod. 2008 Mar;71(3):364-9. Epub 2007 Dec 15.

PMID:
18081257
5.

Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.

Paterson I, Gardner NM, Guzmán E, Wright AE.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6268-72. doi: 10.1016/j.bmcl.2008.09.109. Epub 2008 Oct 11.

PMID:
18951787
6.

Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

Zhu W, Jiménez M, Jung WH, Camarco DP, Balachandran R, Vogt A, Day BW, Curran DP.

J Am Chem Soc. 2010 Jul 7;132(26):9175-87. doi: 10.1021/ja103537u.

7.

Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin.

Shin Y, Fournier JH, Balachandran R, Madiraju C, Raccor BS, Zhu G, Edler MC, Hamel E, Day BW, Curran DP.

Org Lett. 2005 Jul 7;7(14):2873-6.

PMID:
15987158
8.

Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.

Paterson I, Naylor GJ, Gardner NM, Guzmán E, Wright AE.

Chem Asian J. 2011 Feb 1;6(2):459-73. doi: 10.1002/asia.201000541. Epub 2010 Oct 28.

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10.

Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts.

Newman RA, Yang J, Raymond M, Finlay V, Cabral F, Vourloumis D, Stephens LC, Troncoso P, Wu X, Logothetis CJ, Nicolaou KC, Navone NM.

Cancer Chemother Pharmacol. 2001 Oct;48(4):319-26.

PMID:
11710633
11.

Total synthesis and biological evaluation of C16 analogs of (-)-dictyostatin.

Jung WH, Harrison C, Shin Y, Fournier JH, Balachandran R, Raccor BS, Sikorski RP, Vogt A, Curran DP, Day BW.

J Med Chem. 2007 Jun 28;50(13):2951-66. Epub 2007 Jun 2.

PMID:
17542572
12.

Synthesis and biological evaluation of novel analogues of dictyostatin.

Paterson I, Gardner NM, Poullennec KG, Wright AE.

Bioorg Med Chem Lett. 2007 May 1;17(9):2443-7. Epub 2007 Feb 14.

PMID:
17336522
13.

Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization.

Feyen F, Cachoux F, Gertsch J, Wartmann M, Altmann KH.

Acc Chem Res. 2008 Jan;41(1):21-31. Epub 2007 Dec 27. Review.

PMID:
18159935
14.

Epothilone B and its analogs - a new family of anticancer agents.

Altmann KH.

Mini Rev Med Chem. 2003 Mar;3(2):149-58. Review.

PMID:
12570848
15.

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.

Hood KA, West LM, Rouwé B, Northcote PT, Berridge MV, Wakefield SJ, Miller JH.

Cancer Res. 2002 Jun 15;62(12):3356-60.

16.

Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin.

Isbrucker RA, Cummins J, Pomponi SA, Longley RE, Wright AE.

Biochem Pharmacol. 2003 Jul 1;66(1):75-82.

PMID:
12818367
17.

BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.

Lee FY, Borzilleri R, Fairchild CR, Kim SH, Long BH, Reventos-Suarez C, Vite GD, Rose WC, Kramer RA.

Clin Cancer Res. 2001 May;7(5):1429-37.

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Efficient syntheses of 25,26-dihydrodictyostatin and 25,26-dihydro-6-epi-dictyostatin, two potent new microtubule-stabilizing agents.

Jiménez M, Zhu W, Vogt A, Day BW, Curran DP.

Beilstein J Org Chem. 2011;7:1372-8. doi: 10.3762/bjoc.7.161. Epub 2011 Oct 5.

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