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Items: 1 to 20 of 96

1.

An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.

Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL.

J Biol Chem. 2011 Jul 8;286(27):23842-51. doi: 10.1074/jbc.M111.227645. Epub 2011 Apr 13.

2.

Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.

Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, Sturley SL.

J Biol Chem. 2017 Mar 17;292(11):4395-4410. doi: 10.1074/jbc.M116.770578. Epub 2016 Dec 28.

PMID:
28031458
3.

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.

FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12.

PMID:
28082351
4.

Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution.

Malathi K, Higaki K, Tinkelenberg AH, Balderes DA, Almanzar-Paramio D, Wilcox LJ, Erdeniz N, Redican F, Padamsee M, Liu Y, Khan S, Alcantara F, Carstea ED, Morris JA, Sturley SL.

J Cell Biol. 2004 Feb 16;164(4):547-56.

5.

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.

Pipalia NH, Subramanian K, Mao S, Ralph H, Hutt DM, Scott SM, Balch WE, Maxfield FR.

J Lipid Res. 2017 Apr;58(4):695-708. doi: 10.1194/jlr.M072140. Epub 2017 Feb 13. Erratum in: J Lipid Res. 2017 Sep;58(9):1932.

PMID:
28193631
6.

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.

Pipalia NH, Cosner CC, Huang A, Chatterjee A, Bourbon P, Farley N, Helquist P, Wiest O, Maxfield FR.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5620-5. doi: 10.1073/pnas.1014890108. Epub 2011 Mar 21.

7.

Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.

Helquist P, Maxfield FR, Wiech NL, Wiest O.

Neurotherapeutics. 2013 Oct;10(4):688-97. doi: 10.1007/s13311-013-0217-2. Review.

8.

The potential of histone deacetylase inhibitors in Niemann - Pick type C disease.

Maceyka M, Milstien S, Spiegel S.

FEBS J. 2013 Dec;280(24):6367-72. doi: 10.1111/febs.12505. Epub 2013 Sep 23. Review.

9.

Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.

Vilaça R, Silva E, Nadais A, Teixeira V, Matmati N, Gaifem J, Hannun YA, Sá Miranda MC, Costa V.

Mol Microbiol. 2014 Feb;91(3):438-51. doi: 10.1111/mmi.12470. Epub 2013 Dec 12.

10.

Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1.

Sun X, Marks DL, Park WD, Wheatley CL, Puri V, O'Brien JF, Kraft DL, Lundquist PA, Patterson MC, Pagano RE, Snow K.

Am J Hum Genet. 2001 Jun;68(6):1361-72. Epub 2001 May 9.

11.

δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders.

Xu M, Liu K, Swaroop M, Porter FD, Sidhu R, Firnkes S, Ory DS, Marugan JJ, Xiao J, Southall N, Pavan WJ, Davidson C, Walkley SU, Remaley AT, Baxa U, Sun W, McKew JC, Austin CP, Zheng W.

J Biol Chem. 2012 Nov 16;287(47):39349-60. doi: 10.1074/jbc.M112.357707. Epub 2012 Oct 3. Erratum in: J Biol Chem. 2013 Jan 4;288(1):296. Finkes, Sally [corrected to Firnkes, Sally].

12.

High throughput screening identifies modulators of histone deacetylase inhibitors.

Gaupel AC, Begley T, Tenniswood M.

BMC Genomics. 2014 Jun 26;15:528. doi: 10.1186/1471-2164-15-528.

13.

Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.

Contreras PS, Gonzalez-Zuñiga M, González-Hódar L, Yáñez MJ, Dulcey A, Marugan J, Seto E, Alvarez AR, Zanlungo S.

Biochim Biophys Acta. 2016 Feb;1859(2):269-79. doi: 10.1016/j.bbagrm.2015.11.006. Epub 2015 Nov 19.

14.
15.

A yeast model system for functional analysis of the Niemann-Pick type C protein 1 homolog, Ncr1p.

Berger AC, Hanson PK, Wylie Nichols J, Corbett AH.

Traffic. 2005 Oct;6(10):907-17.

16.

Histone deacetylase inhibition decreases cholesterol levels in neuronal cells by modulating key genes in cholesterol synthesis, uptake and efflux.

Nunes MJ, Moutinho M, Gama MJ, Rodrigues CM, Rodrigues E.

PLoS One. 2013;8(1):e53394. doi: 10.1371/journal.pone.0053394. Epub 2013 Jan 10.

17.

Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.

Devlin C, Pipalia NH, Liao X, Schuchman EH, Maxfield FR, Tabas I.

Traffic. 2010 May;11(5):601-15. doi: 10.1111/j.1600-0854.2010.01046.x. Epub 2010 Feb 22.

18.

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.

Neufeld EB, Wastney M, Patel S, Suresh S, Cooney AM, Dwyer NK, Roff CF, Ohno K, Morris JA, Carstea ED, Incardona JP, Strauss JF 3rd, Vanier MT, Patterson MC, Brady RO, Pentchev PG, Blanchette-Mackie EJ.

J Biol Chem. 1999 Apr 2;274(14):9627-35.

19.

The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.

Berger AC, Salazar G, Styers ML, Newell-Litwa KA, Werner E, Maue RA, Corbett AH, Faundez V.

J Cell Sci. 2007 Oct 15;120(Pt 20):3640-52. Epub 2007 Sep 25.

20.

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM.

Nat Med. 2008 Nov;14(11):1247-55. doi: 10.1038/nm.1876. Epub 2008 Oct 26.

PMID:
18953351

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