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Streptococcal M1 protein constructs a pathological host fibrinogen network.

Macheboeuf P, Buffalo C, Fu CY, Zinkernagel AS, Cole JN, Johnson JE, Nizet V, Ghosh P.

Nature. 2011 Apr 7;472(7341):64-8. doi: 10.1038/nature09967.


Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence.

McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P.

Science. 2008 Mar 7;319(5868):1405-8. doi: 10.1126/science.1154470.


Coiled-coil irregularities of the M1 protein structure promote M1-fibrinogen interaction and influence group A Streptococcus host cell interactions and virulence.

Uchiyama S, Andreoni F, Zürcher C, Schilcher K, Ender M, Madon J, Matt U, Ghosh P, Nizet V, Schuepbach RA, Zinkernagel AS.

J Mol Med (Berl). 2013 Jul;91(7):861-9. doi: 10.1007/s00109-013-1012-6. Epub 2013 Feb 27.


Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.

Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmström L, Rosenberger G, Karlsson C, Cazzamali G, Pozdnyakova I, Frick IM, Björck L, Streicher W, Malmström J, Wikström M.

J Biol Chem. 2014 Jun 27;289(26):18175-88. doi: 10.1074/jbc.M114.565978. Epub 2014 May 13.


Determination of the relationship between group A streptococcal genome content, M type, and toxic shock syndrome by a mixed genome microarray.

Vlaminckx BJ, Schuren FH, Montijn RC, Caspers MP, Fluit AC, Wannet WJ, Schouls LM, Verhoef J, Jansen WT.

Infect Immun. 2007 May;75(5):2603-11. Epub 2007 Feb 26.


M1 protein and protein H: IgGFc- and albumin-binding streptococcal surface proteins encoded by adjacent genes.

Akesson P, Schmidt KH, Cooney J, Björck L.

Biochem J. 1994 Jun 15;300 ( Pt 3):877-86.


Human kininogens interact with M protein, a bacterial surface protein and virulence determinant.

Ben Nasr AB, Herwald H, Müller-Esterl W, Björck L.

Biochem J. 1995 Jan 1;305 ( Pt 1):173-80.


Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

Bhattacharya S, Liang Z, Quek AJ, Ploplis VA, Law R, Castellino FJ.

J Biol Chem. 2014 Aug 1;289(31):21684-93. doi: 10.1074/jbc.M114.570218. Epub 2014 Jun 24.


Molecular insight into invasive group A streptococcal disease.

Cole JN, Barnett TC, Nizet V, Walker MJ.

Nat Rev Microbiol. 2011 Sep 16;9(10):724-36. doi: 10.1038/nrmicro2648. Review.


Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein.

Chandrahas V, Glinton K, Liang Z, Donahue DL, Ploplis VA, Castellino FJ.

J Biol Chem. 2015 Jul 24;290(30):18833-42. doi: 10.1074/jbc.M115.655365. Epub 2015 Jun 12.


M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage.

Herwald H, Cramer H, Mörgelin M, Russell W, Sollenberg U, Norrby-Teglund A, Flodgaard H, Lindbom L, Björck L.

Cell. 2004 Feb 6;116(3):367-79.


An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.

Shelburne SA 3rd, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M.

Mol Microbiol. 2011 Dec;82(6):1481-95. doi: 10.1111/j.1365-2958.2011.07902.x. Epub 2011 Nov 21.


Susceptibility of chicken embryos to group A streptococci: correlation with fibrinogen binding.

Schmidt KH, Wiesner J, Gerlach D, Reichardt W, Ozegowski JH, Köhler W.

FEMS Immunol Med Microbiol. 1993 Oct;7(3):231-40.


Mapping of binding sites for human serum albumin and fibrinogen on the M3-protein. Molecular model and function in the pathogenic mechanism.

Reichardt W, Schmidt KH, Amberg C, Gubbe K.

Adv Exp Med Biol. 1997;418:577-9. No abstract available.


The nonideal coiled coil of M protein and its multifarious functions in pathogenesis.

Ghosh P.

Adv Exp Med Biol. 2011;715:197-211. doi: 10.1007/978-94-007-0940-9_12. Review.


Complete genome sequence of Streptococcus pyogenes M1 476, isolated from a patient with streptococcal toxic shock syndrome.

Miyoshi-Akiyama T, Watanabe S, Kirikae T.

J Bacteriol. 2012 Oct;194(19):5466. doi: 10.1128/JB.01265-12.


Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors.

van Bueren AL, Higgins M, Wang D, Burke RD, Boraston AB.

Nat Struct Mol Biol. 2007 Jan;14(1):76-84. Epub 2006 Dec 24.


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