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Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication.

Spencer CM, Schafer XL, Moorman NJ, Munger J.

J Virol. 2011 Jun;85(12):5814-24. doi: 10.1128/JVI.02630-10. Epub 2011 Apr 6.


Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny.

McArdle J, Schafer XL, Munger J.

J Virol. 2011 Jan;85(2):705-14. doi: 10.1128/JVI.01557-10. Epub 2010 Nov 17. Erratum in: J Virol. 2013 Jun;87(12):7197.


Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism.

Hasslacher M, Ivessa AS, Paltauf F, Kohlwein SD.

J Biol Chem. 1993 May 25;268(15):10946-52.


Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication.

Purdy JG, Shenk T, Rabinowitz JD.

Cell Rep. 2015 Mar 3;10(8):1375-85. doi: 10.1016/j.celrep.2015.02.003. Epub 2015 Feb 26.


HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication.

McArdle J, Moorman NJ, Munger J.

PLoS Pathog. 2012 Jan;8(1):e1002502. doi: 10.1371/journal.ppat.1002502. Epub 2012 Jan 26.


Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation.

Marmisolle I, Martínez J, Liu J, Mastrogiovanni M, Fergusson MM, Rovira II, Castro L, Trostchansky A, Moreno M, Cao L, Finkel T, Quijano C.

Arch Biochem Biophys. 2017 Jan 1;613:12-22. doi: 10.1016/ Epub 2016 Oct 27.


Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae.

Shirra MK, Patton-Vogt J, Ulrich A, Liuta-Tehlivets O, Kohlwein SD, Henry SA, Arndt KM.

Mol Cell Biol. 2001 Sep;21(17):5710-22.


Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.

Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12011-6. Epub 2005 Aug 15.


Translational control of human acetyl-CoA carboxylase 1 mRNA is mediated by an internal ribosome entry site in response to ER stress, serum deprivation or hypoxia mimetic CoCl2.

Damiano F, Testini M, Tocci R, Gnoni GV, Siculella L.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):388-398. doi: 10.1016/j.bbalip.2018.01.006. Epub 2018 Jan 16.


Improving production of malonyl coenzyme A-derived metabolites by abolishing Snf1-dependent regulation of Acc1.

Shi S, Chen Y, Siewers V, Nielsen J.

MBio. 2014 May 6;5(3):e01130-14. doi: 10.1128/mBio.01130-14.


Biphasic regulation of A20 gene expression during human cytomegalovirus infection.

Gu SY, Kim YE, Kwon KM, Han TH, Ahn JH.

Virol J. 2014 Jul 8;11:124. doi: 10.1186/1743-422X-11-124.


Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition.

Xu S, Spencer CM, Munger J.

J Virol. 2015 Jun;89(12):6406-17. doi: 10.1128/JVI.03671-14. Epub 2015 Apr 8.


The human cytomegalovirus UL26 protein antagonizes NF-κB activation.

Mathers C, Schafer X, Martínez-Sobrido L, Munger J.

J Virol. 2014 Dec;88(24):14289-300. doi: 10.1128/JVI.02552-14. Epub 2014 Oct 1.


Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication.

Kapoor A, Forman M, Arav-Boger R.

PLoS One. 2014 Mar 26;9(3):e92704. doi: 10.1371/journal.pone.0092704. eCollection 2014.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.

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