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Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice.

Perkins C, Yanase N, Smulian G, Gildea L, Orekov T, Potter C, Brombacher F, Aronow B, Wills-Karp M, Finkelman FD.

J Exp Med. 2011 Apr 11;208(4):853-67. doi: 10.1084/jem.20100023. Epub 2011 Apr 4.


Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin.

Yang M, Hogan SP, Henry PJ, Matthaei KI, McKenzie AN, Young IG, Rothenberg ME, Foster PS.

Am J Respir Cell Mol Biol. 2001 Oct;25(4):522-30.


Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.

Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F.

J Allergy Clin Immunol. 2010 Aug;126(2):347-54. doi: 10.1016/j.jaci.2010.04.028. Epub 2010 Jun 25.


Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity.

Webb DC, Mahalingam S, Cai Y, Matthaei KI, Donaldson DD, Foster PS.

Eur J Immunol. 2003 Dec;33(12):3377-85.


A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness.

Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt MC, Gundel R, Gelfand EW.

J Immunol. 2001 May 1;166(9):5792-800.


Targeting phosphoinositide 3-kinase γ in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness.

Jiang H, Xie Y, Abel PW, Toews ML, Townley RG, Casale TB, Tu Y.

J Pharmacol Exp Ther. 2012 Aug;342(2):305-11. doi: 10.1124/jpet.111.189704. Epub 2012 Apr 27.


IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung.

Mattes J, Yang M, Siqueira A, Clark K, MacKenzie J, McKenzie AN, Webb DC, Matthaei KI, Foster PS.

J Immunol. 2001 Aug 1;167(3):1683-92.


IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle.

Eum SY, Maghni K, Tolloczko B, Eidelman DH, Martin JG.

Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L576-84. Epub 2004 Nov 24.


The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells.

Venkayya R, Lam M, Willkom M, Grünig G, Corry DB, Erle DJ.

Am J Respir Cell Mol Biol. 2002 Feb;26(2):202-8.


Suppressive effect of IL-4 on IL-13-induced genes in mouse lung.

Finkelman FD, Yang M, Perkins C, Schleifer K, Sproles A, Santeliz J, Bernstein JA, Rothenberg ME, Morris SC, Wills-Karp M.

J Immunol. 2005 Apr 15;174(8):4630-8.


Requirement for IL-13 independently of IL-4 in experimental asthma.

Grünig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB.

Science. 1998 Dec 18;282(5397):2261-3.


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE.

Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.


Interleukin-17A directly acts on bronchial smooth muscle cells and augments the contractility.

Chiba Y, Tanoue G, Suto R, Suto W, Hanazaki M, Katayama H, Sakai H.

Pharmacol Rep. 2017 Jun;69(3):377-385. doi: 10.1016/j.pharep.2016.12.007. Epub 2016 Dec 11.


Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma.

Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, Foster PS.

Clin Exp Allergy. 2002 Jul;32(7):1104-11.


Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen.

Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW.

J Allergy Clin Immunol. 2003 Dec;112(6):1078-87.


IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model.

Kim YS, Choi SJ, Choi JP, Jeon SG, Oh S-, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK.

Exp Mol Med. 2010 Aug 31;42(8):533-46.


Natural killer T cells are dispensable in the development of allergen-induced airway hyperresponsiveness, inflammation and remodelling in a mouse model of chronic asthma.

Koh YI, Shim JU, Lee JH, Chung IJ, Min JJ, Rhee JH, Lee HC, Chung DH, Wi JO.

Clin Exp Immunol. 2010 Jul 1;161(1):159-70. doi: 10.1111/j.1365-2249.2010.04151.x. Epub 2010 Apr 29.


Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study.

Hirota JA, Ask K, Fritz D, Ellis R, Wattie J, Richards CD, Labiris R, Kolb M, Inman MD.

Clin Exp Allergy. 2009 Jan;39(1):147-58. doi: 10.1111/j.1365-2222.2008.03109.x. Epub 2008 Oct 11.


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