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Items: 1 to 20 of 125

1.

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4.

2.

Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P.

J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. Erratum in: J Biol Chem. 2012 Jun 1;287(23):19337.

3.

Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7.

4.

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P.

Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4.

5.

Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE).

Sharma R, Gupta B, Sahu AK, Acharya J, Satnami ML, Ghosh KK.

Chem Biol Interact. 2016 Nov 25;259(Pt B):85-92. doi: 10.1016/j.cbi.2016.04.034. Epub 2016 Apr 29.

PMID:
27138243
6.

Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.

Carletti E, Aurbek N, Gillon E, Loiodice M, Nicolet Y, Fontecilla-Camps JC, Masson P, Thiermann H, Nachon F, Worek F.

Biochem J. 2009 Jun 12;421(1):97-106. doi: 10.1042/BJ20090091.

PMID:
19368529
7.

Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).

Karade HN, Raviraju G, Acharya BN, Valiveti AK, Bhalerao U, Acharya J.

Bioorg Med Chem. 2016 Sep 15;24(18):4171-6. doi: 10.1016/j.bmc.2016.07.005. Epub 2016 Jul 6.

PMID:
27450532
8.

Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes.

Radić Z, Dale T, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Duggan BM, Ajami D, Rebek J, Taylor P.

Biochem J. 2013 Feb 15;450(1):231-42. doi: 10.1042/BJ20121612.

9.

In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase.

Jun D, Musilova L, Musilek K, Kuca K.

Int J Mol Sci. 2011;12(3):2077-87. doi: 10.3390/ijms12032077. Epub 2011 Mar 23.

10.

In vitro reactivation of acetylcholinesterase using the oxime K027.

Kuca K, Kassa J.

Vet Hum Toxicol. 2004 Feb;46(1):15-8.

PMID:
14748409
11.

Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase.

Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F.

Toxicol Lett. 2016 Feb 26;244:136-42. doi: 10.1016/j.toxlet.2015.07.007. Epub 2015 Jul 22.

PMID:
26210933
12.

Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.

Chambers JE, Chambers HW, Funck KE, Meek EC, Pringle RB, Ross MK.

Chem Biol Interact. 2016 Nov 25;259(Pt B):154-159. doi: 10.1016/j.cbi.2016.07.004. Epub 2016 Jul 5.

PMID:
27387540
13.

Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study.

Sharma R, Gupta B, Acharya J, Kaushik MP, Ghosh KK.

Toxicology. 2014 Feb 28;316:1-8. doi: 10.1016/j.tox.2013.11.011. Epub 2013 Dec 15.

PMID:
24345352
14.

Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE).

Valiveti AK, Bhalerao UM, Acharya J, Karade HN, Gundapu R, Halve AK, Kaushik MP.

Chem Biol Interact. 2015 Jul 25;237:125-32. doi: 10.1016/j.cbi.2015.06.007. Epub 2015 Jun 10.

PMID:
26070418
15.

Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.

Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V, Dolezal M, Kuca K.

Bioorg Med Chem. 2007 Nov 1;15(21):6733-41. Epub 2007 Aug 10.

PMID:
17764957
16.

Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.

Bartling A, Worek F, Szinicz L, Thiermann H.

Toxicology. 2007 Apr 20;233(1-3):166-72. Epub 2006 Jul 7.

PMID:
16904809
17.

Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase.

Horn G, Wille T, Musilek K, Kuca K, Thiermann H, Worek F.

Arch Toxicol. 2015 Mar;89(3):405-14. doi: 10.1007/s00204-014-1288-5. Epub 2014 Jun 11.

PMID:
24912784
18.

Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes.

Worek F, Wille T, Koller M, Thiermann H.

Chem Biol Interact. 2013 Mar 25;203(1):125-8. doi: 10.1016/j.cbi.2012.07.003. Epub 2012 Jul 22.

PMID:
22827894
19.

Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).

Valiveti AK, Bhalerao UM, Acharya J, Karade HN, Acharya BN, Raviraju G, Halve AK, Kaushik MP.

Bioorg Med Chem. 2015 Aug 1;23(15):4899-910. doi: 10.1016/j.bmc.2015.05.027. Epub 2015 May 22.

PMID:
26043948
20.

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z.

J Med Chem. 2014 Feb 27;57(4):1378-89. doi: 10.1021/jm401650z. Epub 2014 Feb 7.

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