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Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation.

Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng Y.

PLoS One. 2011 Mar 24;6(3):e18002. doi: 10.1371/journal.pone.0018002.


CD28 ligation costimulates cell death but not maturation of double-positive thymocytes due to defective ERK MAPK signaling.

Graham DB, Bell MP, Huntoon CJ, Griffin MD, Tai X, Singer A, McKean DJ.

J Immunol. 2006 Nov 1;177(9):6098-107.


Rho GTPase Cdc42 is essential for human T-cell development.

Smits K, Iannucci V, Stove V, Van Hauwe P, Naessens E, Meuwissen PJ, Ariën KK, Bentahir M, Plum J, Verhasselt B.

Haematologica. 2010 Mar;95(3):367-75. doi: 10.3324/haematol.2009.006890.


A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells.

Lapinski PE, Qiao Y, Chang CH, King PD.

J Immunol. 2011 Jul 1;187(1):151-63. doi: 10.4049/jimmunol.1100178. Epub 2011 Jun 6.


SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner.

Feau S, Schoenberger SP, Altman A, Bécart S.

J Immunol. 2013 Jan 1;190(1):174-83. doi: 10.4049/jimmunol.1201685. Epub 2012 Nov 28.


RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

Priatel JJ, Chen X, Dhanji S, Abraham N, Teh HS.

J Immunol. 2006 Aug 1;177(3):1470-80.


Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage.

Kohu K, Sato T, Ohno S, Hayashi K, Uchino R, Abe N, Nakazato M, Yoshida N, Kikuchi T, Iwakura Y, Inoue Y, Watanabe T, Habu S, Satake M.

J Immunol. 2005 Mar 1;174(5):2627-36.


Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways.

Na S, Li B, Grewal IS, Enslen H, Davis RJ, Hanke JH, Flavell RA.

Oncogene. 1999 Dec 23;18(56):7966-74.


The transient expression of C-C chemokine receptor 8 in thymus identifies a thymocyte subset committed to become CD4+ single-positive T cells.

Kremer L, Carramolino L, Goya I, Zaballos A, Gutiérrez J, Moreno-Ortiz M del C, Martínez-A C, Márquez G.

J Immunol. 2001 Jan 1;166(1):218-25.


Egr2 is required for Bcl-2 induction during positive selection.

Lauritsen JP, Kurella S, Lee SY, Lefebvre JM, Rhodes M, Alberola-Ila J, Wiest DL.

J Immunol. 2008 Dec 1;181(11):7778-85.


The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytes.

Teng F, Zhou Y, Jin R, Chen Y, Pei X, Liu Y, Dong J, Wang W, Pang X, Qian X, Chen WF, Zhang Y, Ge Q.

PLoS One. 2011;6(10):e25567. doi: 10.1371/journal.pone.0025567. Epub 2011 Oct 13.


CD155 is involved in negative selection and is required to retain terminally maturing CD8 T cells in thymus.

Qiu Q, Ravens I, Seth S, Rathinasamy A, Maier MK, Davalos-Misslitz A, Forster R, Bernhardt G.

J Immunol. 2010 Feb 15;184(4):1681-9. doi: 10.4049/jimmunol.0900062. Epub 2010 Jan 4.


Zfat-deficient CD4⁺ CD8⁺ double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK.

Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S.

J Cell Biochem. 2015 Jan;116(1):149-57. doi: 10.1002/jcb.24954.


MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.

Bommhardt U, Scheuring Y, Bickel C, Zamoyska R, Hünig T.

J Immunol. 2000 Mar 1;164(5):2326-37.


Immature CD4+CD8+ thymocytes do not polarize lipid rafts in response to TCR-mediated signals.

Ebert PJ, Baker JF, Punt JA.

J Immunol. 2000 Nov 15;165(10):5435-42.

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