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Items: 1 to 20 of 129

1.

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.

Nature. 2011 Mar 31;471(7340):637-41. doi: 10.1038/nature09814.

2.

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex.

Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K.

Nature. 2011 Mar 31;471(7340):633-6. doi: 10.1038/nature09815.

PMID:
21455180
3.

Linear ubiquitination prevents inflammation and regulates immune signalling.

Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H.

Nature. 2011 Mar 31;471(7340):591-6. doi: 10.1038/nature09816.

PMID:
21455173
4.

IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.

Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, Iwai K.

J Immunol. 2014 Apr 15;192(8):3793-804. doi: 10.4049/jimmunol.1302308. Epub 2014 Mar 14.

5.

Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.

Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM.

PLoS One. 2012;7(5):e36601. doi: 10.1371/journal.pone.0036601. Epub 2012 May 8.

6.

Porcine Reproductive and Respiratory Syndrome Virus nsp1α Inhibits NF-κB Activation by Targeting the Linear Ubiquitin Chain Assembly Complex.

Jing H, Fang L, Ding Z, Wang D, Hao W, Gao L, Ke W, Chen H, Xiao S.

J Virol. 2017 Jan 18;91(3). pii: e01911-16. doi: 10.1128/JVI.01911-16. Print 2017 Feb 1.

7.

Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex.

Fujita H, Rahighi S, Akita M, Kato R, Sasaki Y, Wakatsuki S, Iwai K.

Mol Cell Biol. 2014 Apr;34(7):1322-35. doi: 10.1128/MCB.01538-13. Epub 2014 Jan 27.

8.

Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP.

Goto E, Tokunaga F.

Biochem Biophys Res Commun. 2017 Mar 25;485(1):152-159. doi: 10.1016/j.bbrc.2017.02.040. Epub 2017 Feb 9.

PMID:
28189684
9.

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.

Bowman J, Rodgers MA, Shi M, Amatya R, Hostager B, Iwai K, Gao SJ, Jung JU.

MBio. 2015 Nov 17;6(6):e01777-15. doi: 10.1128/mBio.01777-15.

10.

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.

Sasaki K, Iwai K.

Immunol Rev. 2015 Jul;266(1):175-89. doi: 10.1111/imr.12308. Review.

11.

Reduced SHARPIN and LUBAC Formation May Contribute to CCl₄- or Acetaminophen-Induced Liver Cirrhosis in Mice.

Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H.

Int J Mol Sci. 2017 Feb 4;18(2). pii: E326. doi: 10.3390/ijms18020326.

12.

Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection.

Shimizu S, Fujita H, Sasaki Y, Tsuruyama T, Fukuda K, Iwai K.

Mol Cell Biol. 2016 May 2;36(10):1569-83. doi: 10.1128/MCB.01049-15. Print 2016 May 15.

13.

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.

Nat Cell Biol. 2009 Feb;11(2):123-32. doi: 10.1038/ncb1821. Epub 2009 Jan 11.

PMID:
19136968
14.

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7.

Verhelst K, Carpentier I, Kreike M, Meloni L, Verstrepen L, Kensche T, Dikic I, Beyaert R.

EMBO J. 2012 Oct 3;31(19):3845-55. doi: 10.1038/emboj.2012.240. Epub 2012 Aug 28.

15.

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.

Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03422.

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18.

SHARPIN negatively associates with TRAF2-mediated NFκB activation.

Liang Y.

PLoS One. 2011;6(7):e21696. doi: 10.1371/journal.pone.0021696. Epub 2011 Jul 29.

19.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.

20.

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK.

EMBO J. 2012 Oct 3;31(19):3833-44. doi: 10.1038/emboj.2012.217. Epub 2012 Aug 3.

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