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Items: 1 to 20 of 74

1.

RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis.

Ma T, Keller JA, Yu X.

Acta Biochim Biophys Sin (Shanghai). 2011 May;43(5):339-45. doi: 10.1093/abbs/gmr016. Epub 2011 Mar 28. Review.

2.

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response.

Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W.

J Cell Biol. 2009 Sep 21;186(6):835-47. doi: 10.1083/jcb.200902150.

3.

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, Narita T, Sixma TK, Choudhary C, Bekker-Jensen S, Mailand N.

Nature. 2015 Nov 19;527(7578):389-93. doi: 10.1038/nature15401. Epub 2015 Oct 21.

PMID:
26503038
4.

ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.

Yang H, Palmbos PL, Wang L, Kim EH, Ney GM, Liu C, Prasad J, Misek DE, Yu X, Ljungman M, Simeone DM.

J Biol Chem. 2015 Nov 6;290(45):27146-57. doi: 10.1074/jbc.M115.665489. Epub 2015 Sep 17.

5.

RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment.

Hodge CD, Ismail IH, Edwards RA, Hura GL, Xiao AT, Tainer JA, Hendzel MJ, Glover JN.

J Biol Chem. 2016 Apr 29;291(18):9396-410. doi: 10.1074/jbc.M116.715698. Epub 2016 Feb 22.

PMID:
26903517
6.

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.

Yan J, Jetten AM.

Cancer Lett. 2008 Nov 28;271(2):179-90. doi: 10.1016/j.canlet.2008.04.046. Epub 2008 Jun 11. Review.

7.

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.

Kocyłowski MK, Rey AJ, Stewart GS, Halazonetis TD.

Cell Cycle. 2015;14(11):1748-58. doi: 10.1080/15384101.2015.1010918.

8.

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling.

Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK.

Cell. 2012 Sep 14;150(6):1182-95. doi: 10.1016/j.cell.2012.08.005.

9.

Histone ubiquitination associates with BRCA1-dependent DNA damage response.

Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X.

Mol Cell Biol. 2009 Feb;29(3):849-60. doi: 10.1128/MCB.01302-08. Epub 2008 Nov 17.

10.

RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis.

Lu LY, Wu J, Ye L, Gavrilina GB, Saunders TL, Yu X.

Dev Cell. 2010 Mar 16;18(3):371-84. doi: 10.1016/j.devcel.2010.01.010. Epub 2010 Feb 11.

11.

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.

Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S.

EMBO J. 2012 Apr 18;31(8):1865-78. doi: 10.1038/emboj.2012.47. Epub 2012 Feb 28.

12.

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.

Zhu Q, Sharma N, He J, Wani G, Wani AA.

Cell Cycle. 2015;14(9):1413-25. doi: 10.1080/15384101.2015.1007785.

13.

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks.

Shao G, Lilli DR, Patterson-Fortin J, Coleman KA, Morrissey DE, Greenberg RA.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3166-71. doi: 10.1073/pnas.0807485106. Epub 2009 Feb 6.

14.

Chfr and RNF8 synergistically regulate ATM activation.

Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X.

Nat Struct Mol Biol. 2011 Jun 26;18(7):761-8. doi: 10.1038/nsmb.2078.

15.

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.

16.

An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.

Muñoz MC, Yanez DA, Stark JM.

Nucleic Acids Res. 2014 Jul;42(12):7720-33. doi: 10.1093/nar/gku421. Epub 2014 May 14.

17.

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J.

Cell. 2007 Nov 30;131(5):901-14. Epub 2007 Nov 20.

18.

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S.

Nat Struct Mol Biol. 2011 Nov 20;18(12):1400-7. doi: 10.1038/nsmb.2172.

19.

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.

Feng L, Chen J.

Nat Struct Mol Biol. 2012 Jan 22;19(2):201-6. doi: 10.1038/nsmb.2211.

20.

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

Sharma N, Zhu Q, Wani G, He J, Wang QE, Wani AA.

Cell Cycle. 2014;13(1):106-14. doi: 10.4161/cc.26814. Epub 2013 Oct 24.

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