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Items: 1 to 20 of 101

1.

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent.

Honda T, Dinkova-Kostova AT, David E, Padegimas EM, Sundararajan C, Visnick M, Bumeister R, Christian Wigley W.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2188-91. doi: 10.1016/j.bmcl.2011.03.018.

PMID:
21441026
2.

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent.

Honda T, Padegimas EM, David E, Sundararajan C, Liby KT, Williams C, Sporn MB, Visnick M.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2275-8. doi: 10.1016/j.bmcl.2010.02.007.

3.

Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.

Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT.

Pharmacol Res. 2015 Oct;100:135-47. doi: 10.1016/j.phrs.2015.07.024.

PMID:
26238177
4.
5.

Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW.

Cancer Res. 2006 Feb 15;66(4):2488-94.

6.

The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.

Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB.

Cancer Res. 2005 Jun 1;65(11):4789-98.

8.

The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

Place AE, Suh N, Williams CR, Risingsong R, Honda T, Honda Y, Gribble GW, Leesnitzer LM, Stimmel JB, Willson TM, Rosen E, Sporn MB.

Clin Cancer Res. 2003 Jul;9(7):2798-806.

9.

A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production.

Honda T, Honda Y, Favaloro FG Jr, Gribble GW, Suh N, Place AE, Rendi MH, Sporn MB.

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1027-30.

PMID:
11909709
10.

Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents.

Honda T, Sundararajan C, Yoshizawa H, Su X, Honda Y, Liby KT, Sporn MB, Gribble GW.

J Med Chem. 2007 Apr 19;50(8):1731-4.

11.

Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury.

Zhang F, Wang S, Zhang M, Weng Z, Li P, Gan Y, Zhang L, Cao G, Gao Y, Leak RK, Sporn MB, Chen J.

Stroke. 2012 May;43(5):1390-7. doi: 10.1161/STROKEAHA.111.647420.

12.

Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO).

Onyango EO, Fu L, Cao M, Liby KT, Sporn MB, Gribble GW.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):532-4. doi: 10.1016/j.bmcl.2013.12.034.

PMID:
24388806
13.

CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.

Reisman SA, Buckley DB, Tanaka Y, Klaassen CD.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):109-14. doi: 10.1016/j.taap.2008.12.024.

14.

Cytoprotection of human endothelial cells from oxidant stress with CDDO derivatives: network analysis of genes responsible for cytoprotection.

Bynum JA, Rastogi A, Stavchansky SA, Bowman PD.

Pharmacology. 2015;95(3-4):181-92. doi: 10.1159/000381188.

PMID:
25926128
15.

The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.

Townson JL, Macdonald IC, Liby KT, Mackenzie L, Dales DW, Hedley BD, Foster PJ, Sporn MB, Chambers AF.

Clin Exp Metastasis. 2011 Mar;28(3):309-17. doi: 10.1007/s10585-011-9374-z.

PMID:
21234655
16.

Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.

Honda T, Rounds BV, Bore L, Finlay HJ, Favaloro FG Jr, Suh N, Wang Y, Sporn MB, Gribble GW.

J Med Chem. 2000 Nov 2;43(22):4233-46.

PMID:
11063620
17.

Efficient and scalable synthesis of bardoxolone methyl (cddo-methyl ester).

Fu L, Gribble GW.

Org Lett. 2013 Apr 5;15(7):1622-5. doi: 10.1021/ol400399x.

PMID:
23530743
18.

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.

Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW.

Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44. doi: 10.1016/j.ejphar.2009.08.022.

19.

CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells.

Kim EH, Deng CX, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2011 Mar;4(3):425-34. doi: 10.1158/1940-6207.CAPR-10-0153.

20.

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.

Honda T, Janosik T, Honda Y, Han J, Liby KT, Williams CR, Couch RD, Anderson AC, Sporn MB, Gribble GW.

J Med Chem. 2004 Sep 23;47(20):4923-32.

PMID:
15369396
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