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Items: 1 to 20 of 95

1.

Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells.

Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J.

Cancer Sci. 2011 Jul;102(7):1381-7. doi: 10.1111/j.1349-7006.2011.01932.x. Epub 2011 May 5.

2.

XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.

Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J.

Apoptosis. 2011 May;16(5):502-10. doi: 10.1007/s10495-011-0578-0.

PMID:
21311975
3.

Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.

Wei CC, Ball S, Lin L, Liu A, Fuchs JR, Li PK, Li C, Lin J.

Int J Oncol. 2011 Jan;38(1):279-85.

PMID:
21109950
4.

XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.

Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J.

PLoS One. 2012;7(10):e46624. doi: 10.1371/journal.pone.0046624. Epub 2012 Oct 3.

5.

Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells.

Reed S, Li H, Li C, Lin J.

Biochem Biophys Res Commun. 2011 Apr 15;407(3):450-5. doi: 10.1016/j.bbrc.2011.03.014. Epub 2011 Mar 21.

PMID:
21397587
6.

A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells.

Xiao H, Bid HK, Jou D, Wu X, Yu W, Li C, Houghton PJ, Lin J.

J Biol Chem. 2015 Feb 6;290(6):3418-29. doi: 10.1074/jbc.M114.616748. Epub 2014 Oct 13.

7.

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.

Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV.

Mol Pharmacol. 2007 Nov;72(5):1137-45. Epub 2007 Aug 3.

8.

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J.

Neoplasia. 2010 Jan;12(1):39-50.

9.
10.

SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.

Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV.

Clin Cancer Res. 2006 Nov 15;12(22):6844-52.

11.

Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway.

Fang P, Hwa V, Rosenfeld RG.

Exp Cell Res. 2006 May 1;312(8):1229-39. Epub 2006 Jan 19.

PMID:
16427044
12.

Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.

Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB.

Clin Cancer Res. 2007 May 15;13(10):3024-32.

13.

Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors.

Daka P, Liu A, Karunaratne C, Csatary E, Williams C, Xiao H, Lin J, Xu Z, Page RC, Wang H.

Bioorg Med Chem. 2015 Mar 15;23(6):1348-55. doi: 10.1016/j.bmc.2015.01.025. Epub 2015 Jan 22.

PMID:
25698618
14.

Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells.

Kim SR, Bae MK, Kim JY, Wee HJ, Yoo MA, Bae SK.

Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7. doi: 10.1016/j.bbrc.2009.07.022. Epub 2009 Jul 10.

PMID:
19595669
15.

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J.

Mol Cancer. 2010 Aug 16;9:217. doi: 10.1186/1476-4598-9-217.

16.

Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells.

Um HJ, Min KJ, Kim DE, Kwon TK.

Biochem Biophys Res Commun. 2012 Oct 12;427(1):24-9. doi: 10.1016/j.bbrc.2012.08.133. Epub 2012 Sep 12.

PMID:
22982675
17.

Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation.

Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A, Akiyama Y.

Int J Oncol. 2011 May;38(5):1245-52. doi: 10.3892/ijo.2011.957. Epub 2011 Feb 28.

PMID:
21369699
18.

The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.

Ball S, Li C, Li PK, Lin J.

PLoS One. 2011 Apr 19;6(4):e18820. doi: 10.1371/journal.pone.0018820.

20.

Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell.

Kim J, Lee YJ, Shin DS, Jeon SH, Son KH, Han DC, Jung SN, Oh TK, Kwon BM.

Bioorg Med Chem. 2011 Dec 15;19(24):7582-9. doi: 10.1016/j.bmc.2011.10.025. Epub 2011 Oct 17.

PMID:
22071520

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