Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 118


The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.

Renault VM, Thekkat PU, Hoang KL, White JL, Brady CA, Kenzelmann Broz D, Venturelli OS, Johnson TM, Oskoui PR, Xuan Z, Santo EE, Zhang MQ, Vogel H, Attardi LD, Brunet A.

Oncogene. 2011 Jul 21;30(29):3207-21. doi: 10.1038/onc.2011.35.


Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice.

Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC.

Hepatology. 2010 Sep;52(3):1023-32. doi: 10.1002/hep.23746.


E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors.

Xie Q, Peng S, Tao L, Ruan H, Yang Y, Li TM, Adams U, Meng S, Bi X, Dong MQ, Yuan Z.

J Biol Chem. 2014 Dec 5;289(49):34205-13. doi: 10.1074/jbc.M114.587170.


Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients.

Cho EC, Kuo ML, Liu X, Yang L, Hsieh YC, Wang J, Cheng Y, Yen Y.

Oncotarget. 2014 Jul 15;5(13):4834-44.


FOXO3: A Major Gene for Human Longevity--A Mini-Review.

Morris BJ, Willcox DC, Donlon TA, Willcox BJ.

Gerontology. 2015;61(6):515-25. doi: 10.1159/000375235. Review.


FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage.

Chung YM, Park SH, Tsai WB, Wang SY, Ikeda MA, Berek JS, Chen DJ, Hu MC.

Nat Commun. 2012;3:1000. doi: 10.1038/ncomms2008. Erratum in: Nat Commun. 2013;4:1520.


SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner.

Bollinger LM, Witczak CA, Houmard JA, Brault JJ.

Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C278-87. doi: 10.1152/ajpcell.00391.2013.


The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.

Fortin A, MacLaurin JG, Arbour N, Cregan SP, Kushwaha N, Callaghan SM, Park DS, Albert PR, Slack RS.

J Biol Chem. 2004 Jul 2;279(27):28706-14.


FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma.

Mikse OR, Blake DC Jr, Jones NR, Sun YW, Amin S, Gallagher CJ, Lazarus P, Weisz J, Herzog CR.

Cancer Res. 2010 Aug 1;70(15):6205-15. doi: 10.1158/0008-5472.CAN-09-4008.


FOXO3 modulates endothelial gene expression and function by classical and alternative mechanisms.

Czymai T, Viemann D, Sticht C, Molema G, Goebeler M, Schmidt M.

J Biol Chem. 2010 Apr 2;285(14):10163-78. doi: 10.1074/jbc.M109.056663.


FOXO3 and related transcription factors in development, aging, and exceptional longevity.

Kahn AJ.

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):421-5. doi: 10.1093/gerona/glu044.


Crosstalk between p53 and FOXO transcription factors.

You H, Mak TW.

Cell Cycle. 2005 Jan;4(1):37-8.


The life-extending effect of dietary restriction requires Foxo3 in mice.

Shimokawa I, Komatsu T, Hayashi N, Kim SE, Kawata T, Park S, Hayashi H, Yamaza H, Chiba T, Mori R.

Aging Cell. 2015 Aug;14(4):707-9. doi: 10.1111/acel.12340.


Methylation by Set9 modulates FoxO3 stability and transcriptional activity.

Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A.

Aging (Albany NY). 2012 Jul;4(7):462-79.


Discovery of an integrative network of microRNAs and transcriptomics changes for acute kidney injury.

Lee CG, Kim JG, Kim HJ, Kwon HK, Cho IJ, Choi DW, Lee WH, Kim WD, Hwang SJ, Choi S, Kim SG.

Kidney Int. 2014 Nov;86(5):943-53. doi: 10.1038/ki.2014.117.


The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.

Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB.

J Biol Chem. 2009 Apr 17;284(16):10334-42. doi: 10.1074/jbc.M808848200.


FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.

Shats I, Gatza ML, Liu B, Angus SP, You L, Nevins JR.

Cancer Res. 2013 Oct 1;73(19):6056-67. doi: 10.1158/0008-5472.CAN-13-0453.


An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.

Lam M, Carmichael AR, Griffiths HR.

PLoS One. 2012;7(6):e40152. doi: 10.1371/journal.pone.0040152. Erratum in: PLoS One. 2014 Jul;9(7):e102655.


Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

Jabbour AM, Daunt CP, Green BD, Vogel S, Gordon L, Lee RS, Silke N, Pearson RB, Vandenberg CJ, Kelly PN, Nutt SL, Strasser A, Borner C, Ekert PG.

Blood. 2010 Jan 14;115(2):344-52. doi: 10.1182/blood-2009-07-230730.

Items per page

Supplemental Content

Support Center