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Items: 1 to 20 of 150


ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.

Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J.

Mol Cell. 2011 Mar 18;41(6):661-71. doi: 10.1016/j.molcel.2011.02.031.


Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness.

Hu J, Mukhopadhyay A, Craig AW.

J Biol Chem. 2011 Jan 21;286(3):2261-72. doi: 10.1074/jbc.M110.157974. Epub 2010 Nov 9.


Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2.

Abou-Kheir W, Isaac B, Yamaguchi H, Cox D.

J Cell Sci. 2008 Feb 1;121(Pt 3):379-90. doi: 10.1242/jcs.010272. Epub 2008 Jan 15.


Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions.

Wu S, Ma L, Wu Y, Zeng R, Zhu X.

Cell Res. 2012 Aug;22(8):1270-84. doi: 10.1038/cr.2012.47. Epub 2012 Mar 27.


Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.

Krause M, Gautreau A.

Nat Rev Mol Cell Biol. 2014 Sep;15(9):577-90. doi: 10.1038/nrm3861. Review.


Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G.

Nat Cell Biol. 2004 Apr;6(4):319-27. Epub 2004 Mar 28.


A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages.

Kheir WA, Gevrey JC, Yamaguchi H, Isaac B, Cox D.

J Cell Sci. 2005 Nov 15;118(Pt 22):5369-79.


Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.

Nakanishi O, Suetsugu S, Yamazaki D, Takenawa T.

J Biochem. 2007 Mar;141(3):319-25. Epub 2007 Jan 3.


Phosphoregulation of the WAVE regulatory complex and signal integration.

Mendoza MC.

Semin Cell Dev Biol. 2013 Apr;24(4):272-9. doi: 10.1016/j.semcdb.2013.01.007. Epub 2013 Jan 24. Review.


Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.

Carabeo RA, Dooley CA, Grieshaber SS, Hackstadt T.

Cell Microbiol. 2007 Sep;9(9):2278-88. Epub 2007 May 15.


Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells.

Yang C, Czech L, Gerboth S, Kojima S, Scita G, Svitkina T.

PLoS Biol. 2007 Nov;5(11):e317.


Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex.

Isogai T, van der Kammen R, Leyton-Puig D, Kedziora KM, Jalink K, Innocenti M.

J Cell Sci. 2015 Oct 15;128(20):3796-810. doi: 10.1242/jcs.176768. Epub 2015 Sep 8.


alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells.

Maddala R, Rao VP.

Exp Cell Res. 2005 May 15;306(1):203-15. Epub 2005 Mar 17.


Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM.

Curr Biol. 2013 Jan 21;23(2):107-17. doi: 10.1016/j.cub.2012.11.059. Epub 2012 Dec 27.


Direct interaction between exocyst and Wave complexes promotes cell protrusions and motility.

Biondini M, Sadou-Dubourgnoux A, Paul-Gilloteaux P, Zago G, Arslanhan MD, Waharte F, Formstecher E, Hertzog M, Yu J, Guerois R, Gautreau A, Scita G, Camonis J, Parrini MC.

J Cell Sci. 2016 Oct 15;129(20):3756-3769. Epub 2016 Sep 2.


The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.

Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.

Blood. 2007 Nov 15;110(10):3637-47. Epub 2007 Jul 30.


Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer.

Yokotsuka M, Iwaya K, Saito T, Pandiella A, Tsuboi R, Kohno N, Matsubara O, Mukai K.

Breast Cancer Res Treat. 2011 Apr;126(2):311-8. doi: 10.1007/s10549-010-0896-x. Epub 2010 Apr 24.


Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration.

Liu J, Zhao Y, Sun Y, He B, Yang C, Svitkina T, Goldman YE, Guo W.

Curr Biol. 2012 Aug 21;22(16):1510-5. doi: 10.1016/j.cub.2012.05.055. Epub 2012 Jun 28.


Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

Steffen A, Rottner K, Ehinger J, Innocenti M, Scita G, Wehland J, Stradal TE.

EMBO J. 2004 Feb 25;23(4):749-59. Epub 2004 Feb 5.


The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex.

Sekino S, Kashiwagi Y, Kanazawa H, Takada K, Baba T, Sato S, Inoue H, Kojima M, Tani K.

Cell Commun Signal. 2015 Oct 1;13:41. doi: 10.1186/s12964-015-0119-5.

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