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Pancreatic cancers require autophagy for tumor growth.

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC.

Genes Dev. 2011 Apr 1;25(7):717-29. doi: 10.1101/gad.2016111. Epub 2011 Mar 15.


A critical role for autophagy in pancreatic cancer.

Yang S, Kimmelman AC.

Autophagy. 2011 Aug;7(8):912-3. Epub 2011 Aug 1.


Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling.

Balic A, Sørensen MD, Trabulo SM, Sainz B Jr, Cioffi M, Vieira CR, Miranda-Lorenzo I, Hidalgo M, Kleeff J, Erkan M, Heeschen C.

Mol Cancer Ther. 2014 Jul;13(7):1758-71. doi: 10.1158/1535-7163.MCT-13-0948. Epub 2014 Apr 30.


Autophagy is needed for the growth of pancreatic adenocarcinoma and has a cytoprotective effect against anticancer drugs.

Hashimoto D, Bläuer M, Hirota M, Ikonen NH, Sand J, Laukkarinen J.

Eur J Cancer. 2014 May;50(7):1382-90. doi: 10.1016/j.ejca.2014.01.011. Epub 2014 Feb 3.


Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment.

Rausch V, Liu L, Apel A, Rettig T, Gladkich J, Labsch S, Kallifatidis G, Kaczorowski A, Groth A, Gross W, Gebhard MM, Schemmer P, Werner J, Salnikov AV, Zentgraf H, Büchler MW, Herr I.

J Pathol. 2012 Jul;227(3):325-35. doi: 10.1002/path.3994. Epub 2012 Apr 18.


Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status.

Yang A, Kimmelman AC.

Autophagy. 2014 Sep;10(9):1683-4. doi: 10.4161/auto.29961. Epub 2014 Jul 17.


Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation.

Ding ZB, Hui B, Shi YH, Zhou J, Peng YF, Gu CY, Yang H, Shi GM, Ke AW, Wang XY, Song K, Dai Z, Shen YH, Fan J.

Clin Cancer Res. 2011 Oct 1;17(19):6229-38. doi: 10.1158/1078-0432.CCR-11-0816. Epub 2011 Aug 8.


Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism.

Donadelli M, Dando I, Zaniboni T, Costanzo C, Dalla Pozza E, Scupoli MT, Scarpa A, Zappavigna S, Marra M, Abbruzzese A, Bifulco M, Caraglia M, Palmieri M.

Cell Death Dis. 2011 Apr 28;2:e152. doi: 10.1038/cddis.2011.36.


Chemotherapy and autophagy-mediated cell death in pancreatic cancer cells.

Ropolo A, Bagnes CI, Molejon MI, Lo Re A, Boggio V, Gonzalez CD, Vaccaro MI.

Pancreatology. 2012 Jan-Feb;12(1):1-7. doi: 10.1016/j.pan.2011.11.003. Epub 2011 Nov 20. Review.


Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.

Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC.

Cancer Discov. 2014 Aug;4(8):905-13. doi: 10.1158/2159-8290.CD-14-0362. Epub 2014 May 29.


Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.

Min H, Xu M, Chen ZR, Zhou JD, Huang M, Zheng K, Zou XP.

Cancer Chemother Pharmacol. 2014 Jul;74(1):167-76. doi: 10.1007/s00280-014-2451-7. Epub 2014 May 20.


Transforming Growth Factor TGFβ Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic Ductal Adenocarcinomas.

Song K, Hu W, Yue F, Zou J, Li W, Chen Q, Yao Q, Sun W, Liu L.

PLoS One. 2015 Nov 16;10(11):e0143150. doi: 10.1371/journal.pone.0143150. eCollection 2015.


[Autophagy: a necessary allied in the growth of pancreatic adenocarcinoma].

Larsen CJ.

Bull Cancer. 2011 Jul;98(7):719-22. French. No abstract available.


Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy.

Frieboes HB, Huang JS, Yin WC, McNally LR.

JOP. 2014 Mar 10;15(2):189-97. doi: 10.6092/1590-8577/1900.


Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer.

Von Marschall Z, Scholz A, Stacker SA, Achen MG, Jackson DG, Alves F, Schirner M, Haberey M, Thierauch KH, Wiedenmann B, Rosewicz S.

Int J Oncol. 2005 Sep;27(3):669-79.


Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.

Lebedeva IV, Su ZZ, Sarkar D, Gopalkrishnan RV, Waxman S, Yacoub A, Dent P, Fisher PB.

Oncogene. 2005 Jan 20;24(4):585-96.


Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma.

Gómez VE, Giovannetti E, Peters GJ.

Semin Cancer Biol. 2015 Dec;35:11-9. doi: 10.1016/j.semcancer.2015.09.011. Epub 2015 Sep 25. Review.


PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells.

Ozpolat B, Akar U, Mehta K, Lopez-Berestein G.

Autophagy. 2007 Sep-Oct;3(5):480-3. Epub 2007 Apr 27. Erratum in: Autophagy. 2009 Feb;5(2):283.


EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage.

Kuroda S, Tam J, Roth JA, Sokolov K, Ramesh R.

Int J Nanomedicine. 2014 Aug 8;9:3825-39. doi: 10.2147/IJN.S65990. eCollection 2014.

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