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Items: 1 to 20 of 164

1.

Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei.

Liu N, Cummings JE, England K, Slayden RA, Tonge PJ.

J Antimicrob Chemother. 2011 Mar;66(3):564-73. doi: 10.1093/jac/dkq509. Epub 2011 Jan 22.

2.

AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei--Crystal structure, mode of action, and biological activity.

Rao KN, Lakshminarasimhan A, Joseph S, Lekshmi SU, Lau MS, Takhi M, Sreenivas K, Nathan S, Yusof R, Abd Rahman N, Ramachandra M, Antony T, Subramanya H.

Protein Sci. 2015 May;24(5):832-40. doi: 10.1002/pro.2655. Epub 2015 Apr 2.

3.

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.

Neckles C, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo L, Yu W, Davoodi S, Slayden RA, Kisker C, Tonge PJ.

Biochemistry. 2017 Apr 4;56(13):1865-1878. doi: 10.1021/acs.biochem.6b01048. Epub 2017 Mar 21.

PMID:
28225601
4.

Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei.

Lu H, Tonge PJ.

Biochemistry. 2010 Feb 16;49(6):1281-9. doi: 10.1021/bi902001a.

5.

Vibrio cholerae FabV defines a new class of enoyl-acyl carrier protein reductase.

Massengo-Tiassé RP, Cronan JE.

J Biol Chem. 2008 Jan 18;283(3):1308-16. Epub 2007 Nov 21.

6.

Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei.

Cummings JE, Beaupre AJ, Knudson SE, Liu N, Yu W, Neckles C, Wang H, Khanna A, Bommineni GR, Trunck LA, Schweizer HP, Tonge PJ, Slayden RA.

Antimicrob Agents Chemother. 2014;58(3):1646-51. doi: 10.1128/AAC.02296-13. Epub 2013 Dec 30.

7.

The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy.

Cummings JE, Kingry LC, Rholl DA, Schweizer HP, Tonge PJ, Slayden RA.

Antimicrob Agents Chemother. 2014;58(2):931-5. doi: 10.1128/AAC.00176-13. Epub 2013 Nov 25.

11.

The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.

Heath RJ, Su N, Murphy CK, Rock CO.

J Biol Chem. 2000 Dec 22;275(51):40128-33.

12.

Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase.

Zhu L, Lin J, Ma J, Cronan JE, Wang H.

Antimicrob Agents Chemother. 2010 Feb;54(2):689-98. doi: 10.1128/AAC.01152-09. Epub 2009 Nov 23.

13.
14.

Escherichia coli enoyl-acyl carrier protein reductase (FabI) supports efficient operation of a functional reversal of β-oxidation cycle.

Vick JE, Clomburg JM, Blankschien MD, Chou A, Kim S, Gonzalez R.

Appl Environ Microbiol. 2015 Feb;81(4):1406-16.

15.

Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway.

Lu H, Tonge PJ.

Acc Chem Res. 2008 Jan;41(1):11-20. doi: 10.1021/ar700156e. Review.

PMID:
18193820
16.

Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.

Kitagawa H, Ozawa T, Takahata S, Iida M, Saito J, Yamada M.

J Med Chem. 2007 Sep 20;50(19):4710-20. Epub 2007 Aug 22.

PMID:
17713898
17.

Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli.

Bergler H, Wallner P, Ebeling A, Leitinger B, Fuchsbichler S, Aschauer H, Kollenz G, Högenauer G, Turnowsky F.

J Biol Chem. 1994 Feb 25;269(8):5493-6.

18.

Signature gene expression profile of triclosan-resistant Escherichia coli.

Yu BJ, Kim JA, Pan JG.

J Antimicrob Chemother. 2010 Jun;65(6):1171-7. doi: 10.1093/jac/dkq114. Epub 2010 Apr 21.

PMID:
20410062
19.

Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets.

Wen L, Chmielowski JN, Bohn KC, Huang JK, Timsina YN, Kodali P, Pathak AK.

Protein Expr Purif. 2009 May;65(1):83-91. doi: 10.1016/j.pep.2008.11.011. Epub 2008 Dec 6.

PMID:
19095065
20.

Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.

Sivaraman S, Zwahlen J, Bell AF, Hedstrom L, Tonge PJ.

Biochemistry. 2003 Apr 22;42(15):4406-13.

PMID:
12693936

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