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Items: 1 to 20 of 90

1.

Computational design of the sequence and structure of a protein-binding peptide.

Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B.

J Am Chem Soc. 2011 Mar 30;133(12):4190-2. doi: 10.1021/ja110296z.

2.

GoLoco motif proteins binding to Galpha(i1): insights from molecular simulations.

Khafizov K.

J Mol Model. 2009 Dec;15(12):1491-9. doi: 10.1007/s00894-009-0516-z.

3.

Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.

Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP.

J Biol Chem. 2011 Feb 4;286(5):3351-8. doi: 10.1074/jbc.M110.190496.

4.

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.

Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP.

Structure. 2005 Jul;13(7):1069-80.

6.

D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides.

Webb CK, McCudden CR, Willard FS, Kimple RJ, Siderovski DP, Oxford GS.

J Neurochem. 2005 Mar;92(6):1408-18.

7.

Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.

Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM.

Biochemistry. 2009 Mar 31;48(12):2630-42. doi: 10.1021/bi801853a. Erratum in: Biochemistry. 2010 Nov 23;49(46):10037.

8.
9.

Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation.

Medkova M, Preininger AM, Yu NJ, Hubbell WL, Hamm HE.

Biochemistry. 2002 Aug 6;41(31):9962-72.

PMID:
12146960
10.

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.

Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP.

Nature. 2002 Apr 25;416(6883):878-81.

PMID:
11976690
11.

Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins.

Jones JC, Jones AM, Temple BR, Dohlman HG.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7275-9. doi: 10.1073/pnas.1202943109.

12.

Evidence for a second, high affinity Gbetagamma binding site on Galphai1(GDP) subunits.

Wang J, Sengupta P, Guo Y, Golebiewska U, Scarlata S.

J Biol Chem. 2009 Jun 19;284(25):16906-13. doi: 10.1074/jbc.M109.006585.

13.

The R6A-1 peptide binds to switch II of Galphai1 but is not a GDP-dissociation inhibitor.

Willard FS, Siderovski DP.

Biochem Biophys Res Commun. 2006 Jan 27;339(4):1107-12.

PMID:
16338227
14.

Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis.

Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR.

Structure. 1996 Nov 15;4(11):1277-90.

PMID:
8939752
15.
16.

Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.

Johnston CA, Lobanova ES, Shavkunov AS, Low J, Ramer JK, Blaesius R, Fredericks Z, Willard FS, Kuhlman B, Arshavsky VY, Siderovski DP.

Biochemistry. 2006 Sep 26;45(38):11390-400.

17.

Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state.

Mase Y, Yokogawa M, Osawa M, Shimada I.

Biomol NMR Assign. 2014 Oct;8(2):237-41. doi: 10.1007/s12104-013-9491-5.

PMID:
23771857
18.

The RGS14 GoLoco domain discriminates among Galphai isoforms.

Mittal V, Linder ME.

J Biol Chem. 2004 Nov 5;279(45):46772-8.

19.

A peptide core motif for binding to heterotrimeric G protein alpha subunits.

Ja WW, Adhikari A, Austin RJ, Sprang SR, Roberts RW.

J Biol Chem. 2005 Sep 16;280(37):32057-60.

20.

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins.

Willard FS, Low AB, McCudden CR, Siderovski DP.

Cell Signal. 2007 Feb;19(2):428-38.

PMID:
16949794
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