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Items: 1 to 20 of 99

1.

Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.

Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS.

J Biol Chem. 2011 Apr 29;286(17):15298-307. doi: 10.1074/jbc.M111.226225. Epub 2011 Mar 7.

2.

Plastid-associated porphobilinogen synthase from Toxoplasma gondii: kinetic and structural properties validate therapeutic potential.

Shanmugam D, Wu B, Ramirez U, Jaffe EK, Roos DS.

J Biol Chem. 2010 Jul 16;285(29):22122-31. doi: 10.1074/jbc.M110.107243. Epub 2010 May 4.

3.

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK.

Nat Struct Biol. 2003 Sep;10(9):757-63. Epub 2003 Aug 3.

PMID:
12897770
4.

Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions.

Frankenberg N, Jahn D, Jaffe EK.

Biochemistry. 1999 Oct 19;38(42):13976-82.

PMID:
10529244
5.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

6.

The Remarkable Character of Porphobilinogen Synthase.

Jaffe EK.

Acc Chem Res. 2016 Nov 15;49(11):2509-2517. Epub 2016 Oct 26.

PMID:
27783504
7.

Porphobilinogen synthase, the first source of heme's asymmetry.

Jaffe EK.

J Bioenerg Biomembr. 1995 Apr;27(2):169-79. Review.

PMID:
7592564
8.
9.

Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer.

Bollivar DW, Clauson C, Lighthall R, Forbes S, Kokona B, Fairman R, Kundrat L, Jaffe EK.

BMC Biochem. 2004 Nov 22;5:17.

10.

Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation.

Kokona B, Rigotti DJ, Wasson AS, Lawrence SH, Jaffe EK, Fairman R.

Biochemistry. 2008 Oct 7;47(40):10649-56. doi: 10.1021/bi801128d. Epub 2008 Sep 17.

11.
12.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70. Epub 2004 Dec 21.

PMID:
15644204
13.

High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase.

Frankenberg N, Erskine PT, Cooper JB, Shoolingin-Jordan PM, Jahn D, Heinz DW.

J Mol Biol. 1999 Jun 11;289(3):591-602.

PMID:
10356331
14.

Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.

Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A.

Biochemistry. 2001 Jul 27;40(28):8227-36.

PMID:
11444968
15.

Allosteric inhibition of human porphobilinogen synthase.

Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK.

J Biol Chem. 2009 Dec 18;284(51):35807-17. doi: 10.1074/jbc.M109.026294.

16.

Allostery and the dynamic oligomerization of porphobilinogen synthase.

Jaffe EK, Lawrence SH.

Arch Biochem Biophys. 2012 Mar 15;519(2):144-53. doi: 10.1016/j.abb.2011.10.010. Epub 2011 Oct 19. Review.

17.

The porphobilinogen synthase catalyzed reaction mechanism.

Jaffe EK.

Bioorg Chem. 2004 Oct;32(5):316-25. Review.

PMID:
15381398
19.

Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism.

Frère F, Schubert WD, Stauffer F, Frankenberg N, Neier R, Jahn D, Heinz DW.

J Mol Biol. 2002 Jul 5;320(2):237-47.

PMID:
12079382
20.

Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase.

Selwood T, Tang L, Lawrence SH, Anokhina Y, Jaffe EK.

Biochemistry. 2008 Mar 11;47(10):3245-57. doi: 10.1021/bi702113z. Epub 2008 Feb 14.

PMID:
18271513

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