Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 108

1.

Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures.

Cecchini S, Virag T, Kotin RM.

Hum Gene Ther. 2011 Aug;22(8):1021-30. doi: 10.1089/hum.2010.250. Epub 2011 May 16.

2.

Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: from shake flasks to a 20-L bioreactor.

Meghrous J, Aucoin MG, Jacob D, Chahal PS, Arcand N, Kamen AA.

Biotechnol Prog. 2005 Jan-Feb;21(1):154-60.

PMID:
15903253
3.

Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy.

Negrete A, Esteban G, Kotin RM.

Appl Microbiol Biotechnol. 2007 Sep;76(4):761-72. Epub 2007 Aug 7.

PMID:
17680241
4.

Improving adeno-associated vector yield in high density insect cell cultures.

Mena JA, Aucoin MG, Montes J, Chahal PS, Kamen AA.

J Gene Med. 2010 Feb;12(2):157-67. doi: 10.1002/jgm.1420.

PMID:
20101623
5.

Large-scale production of recombinant adeno-associated viral vectors.

Negrete A, Kotin RM.

Methods Mol Biol. 2008;433:79-96. doi: 10.1007/978-1-59745-237-3_5.

PMID:
18679618
6.

Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells.

Durocher Y, Pham PL, St-Laurent G, Jacob D, Cass B, Chahal P, Lau CJ, Nalbantoglu J, Kamen A.

J Virol Methods. 2007 Sep;144(1-2):32-40. Epub 2007 Apr 30.

PMID:
17467815
7.

Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales.

Negrete A, Kotin RM.

J Virol Methods. 2007 Nov;145(2):155-61. Epub 2007 Jul 2.

8.

Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology.

Negrete A, Kotin RM.

Brief Funct Genomic Proteomic. 2008 Jul;7(4):303-11. doi: 10.1093/bfgp/eln034. Epub 2008 Jul 16. Review.

9.

Insect cells as a factory to produce adeno-associated virus type 2 vectors.

Urabe M, Ding C, Kotin RM.

Hum Gene Ther. 2002 Nov 1;13(16):1935-43.

PMID:
12427305
10.

Using a fed-batch culture strategy to enhance rAAV production in the baculovirus/insect cell system.

Liu YK, Yang CJ, Liu CL, Shen CR, Shiau LD.

J Biosci Bioeng. 2010 Aug;110(2):187-93. doi: 10.1016/j.jbiosc.2010.02.004. Epub 2010 Mar 11.

PMID:
20547323
11.

Scalable production of adeno-associated virus type 2 vectors via suspension transfection.

Park JY, Lim BP, Lee K, Kim YG, Jo EC.

Biotechnol Bioeng. 2006 Jun 20;94(3):416-30.

PMID:
16622883
12.

High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap.

Conway JE, Rhys CM, Zolotukhin I, Zolotukhin S, Muzyczka N, Hayward GS, Byrne BJ.

Gene Ther. 1999 Jun;6(6):986-93.

13.

Scalable recombinant adeno-associated virus production using recombinant herpes simplex virus type 1 coinfection of suspension-adapted mammalian cells.

Thomas DL, Wang L, Niamke J, Liu J, Kang W, Scotti MM, Ye GJ, Veres G, Knop DR.

Hum Gene Ther. 2009 Aug;20(8):861-70. doi: 10.1089/hum.2009.004.

PMID:
19419276
14.

Sodium Chloride Enhances Recombinant Adeno-Associated Virus Production in a Serum-Free Suspension Manufacturing Platform Using the Herpes Simplex Virus System.

Adamson-Small L, Potter M, Byrne BJ, Clément N.

Hum Gene Ther Methods. 2017 Feb;28(1):1-14. doi: 10.1089/hgtb.2016.151.

15.

A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells.

Smith RH, Levy JR, Kotin RM.

Mol Ther. 2009 Nov;17(11):1888-96. doi: 10.1038/mt.2009.128. Epub 2009 Jun 16.

16.

Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system.

Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM.

J Gene Med. 2007 Nov;9(11):938-48.

PMID:
17764098
17.

Toward exascale production of recombinant adeno-associated virus for gene transfer applications.

Cecchini S, Negrete A, Kotin RM.

Gene Ther. 2008 Jun;15(11):823-30. doi: 10.1038/gt.2008.61. Epub 2008 Apr 10. Review.

PMID:
18401433
18.

Combination of baculovirus-mediated gene delivery and packed-bed reactor for scalable production of adeno-associated virus.

Huang KS, Lo WH, Chung YC, Lai YK, Chen CY, Chou ST, Hu YC.

Hum Gene Ther. 2007 Nov;18(11):1161-70.

PMID:
17944574
19.
20.

Manufacturing Clinical Grade Recombinant Adeno-Associated Virus Using Invertebrate Cell Lines.

Kotin RM, Snyder RO.

Hum Gene Ther. 2017 Apr;28(4):350-360. doi: 10.1089/hum.2017.042.

PMID:
28351174

Supplemental Content

Support Center