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Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.

Akunuru S, Palumbo J, Zhai QJ, Zheng Y.

PLoS One. 2011 Feb 9;6(2):e16951. doi: 10.1371/journal.pone.0016951.


Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma.

Narita K, Matsuda Y, Seike M, Naito Z, Gemma A, Ishiwata T.

Int J Oncol. 2014 Apr;44(4):1118-30. doi: 10.3892/ijo.2014.2278.


EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.

Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP.

Mol Cancer. 2012 Sep 25;11:73. doi: 10.1186/1476-4598-11-73.


Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer.

Zhu X, Gao G, Chu K, Yang X, Ren S, Li Y, Wu H, Huang Y, Zhou C.

Int J Biochem Cell Biol. 2015 Apr;61:103-14. doi: 10.1016/j.biocel.2015.02.005.


Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP.

PLoS One. 2012;7(4):e35040. doi: 10.1371/journal.pone.0035040.


The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.

Yoon CH, Hyun KH, Kim RK, Lee H, Lim EJ, Chung HY, An S, Park MJ, Suh Y, Kim MJ, Lee SJ.

FEBS Lett. 2011 Jul 21;585(14):2331-8. doi: 10.1016/j.febslet.2011.05.070.


ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells.

Ota M, Mochizuki S, Shimoda M, Abe H, Miyamae Y, Ishii K, Kimura H, Okada Y.

Cancer Sci. 2016 Apr;107(4):433-43. doi: 10.1111/cas.12895.


Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.

Li X, Wan L, Geng J, Wu CL, Bai X.

J Thorac Oncol. 2012 Aug;7(8):1235-45. doi: 10.1097/JTO.0b013e318257cc6d.


Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cells.

Wang X, Liu Q, Hou B, Zhang W, Yan M, Jia H, Li H, Yan D, Zheng F, Ding W, Yi C, Hai Wang.

PLoS One. 2013 Sep 11;8(9):e73942. doi: 10.1371/journal.pone.0073942.


Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity.

Akunuru S, James Zhai Q, Zheng Y.

Cell Death Dis. 2012 Jul 19;3:e352. doi: 10.1038/cddis.2012.93.


The role of Rac1 in the regulation of NF-κB activity, cell proliferation, and cell migration in non-small cell lung carcinoma.

Gastonguay A, Berg T, Hauser AD, Schuld N, Lorimer E, Williams CL.

Cancer Biol Ther. 2012 Jun;13(8):647-56. doi: 10.4161/cbt.20082.


Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway.

Shao C, Sullivan JP, Girard L, Augustyn A, Yenerall P, Rodriguez-Canales J, Liu H, Behrens C, Shay JW, Wistuba II, Minna JD.

Clin Cancer Res. 2014 Aug 1;20(15):4154-66. doi: 10.1158/1078-0432.CCR-13-3292.


JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.

Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J.

Cancer Res. 2014 May 1;74(9):2444-54. doi: 10.1158/0008-5472.CAN-13-2136.


Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer.

Sette G, Salvati V, Mottolese M, Visca P, Gallo E, Fecchi K, Pilozzi E, Duranti E, Policicchio E, Tartaglia M, Milella M, De Maria R, Eramo A.

Cell Death Dis. 2015 Aug 6;6:e1850. doi: 10.1038/cddis.2015.217.


SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity.

Nakatsugawa M, Takahashi A, Hirohashi Y, Torigoe T, Inoda S, Murase M, Asanuma H, Tamura Y, Morita R, Michifuri Y, Kondo T, Hasegawa T, Takahashi H, Sato N.

Lab Invest. 2011 Dec;91(12):1796-804. doi: 10.1038/labinvest.2011.140.


Mechanisms of RhoGDI2 mediated lung cancer epithelial-mesenchymal transition suppression.

Niu H, Wu B, Jiang H, Li H, Zhang Y, Peng Y, He P.

Cell Physiol Biochem. 2014;34(6):2007-16. doi: 10.1159/000366396.


RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer.

Kaneto N, Yokoyama S, Hayakawa Y, Kato S, Sakurai H, Saiki I.

Cancer Sci. 2014 Jul;105(7):788-94. doi: 10.1111/cas.12425.


Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.

Niess H, Camaj P, Renner A, Ischenko I, Zhao Y, Krebs S, Mysliwietz J, Jäckel C, Nelson PJ, Blum H, Jauch KW, Ellwart JW, Bruns CJ.

Target Oncol. 2015 Jun;10(2):215-27. doi: 10.1007/s11523-014-0323-z.

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