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Items: 1 to 20 of 152


Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.

Niens M, Grier AE, Marron M, Kay TW, Greiner DL, Serreze DV.

Diabetes. 2011 Apr;60(4):1229-36. doi: 10.2337/db10-1523.


Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, der Kracht SM, Kester MG, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO.

PLoS One. 2012;7(11):e49213. doi: 10.1371/journal.pone.0049213.


Identification of autoreactive CD8+ T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients.

Li Y, Zhou L, Li Y, Zhang J, Guo B, Meng G, Chen X, Zheng Q, Zhang L, Zhang M, Wang L.

Clin Immunol. 2015 Jul;159(1):63-71. doi: 10.1016/j.clim.2015.04.017.


HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.

Takaki T, Marron MP, Mathews CE, Guttmann ST, Bottino R, Trucco M, DiLorenzo TP, Serreze DV.

J Immunol. 2006 Mar 1;176(5):3257-65.


Genetic and therapeutic control of diabetogenic CD8+ T cells.

Santamaria P.

Novartis Found Symp. 2008;292:130-6; discussion 136-45, 202-3.


Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin.

Jarchum I, DiLorenzo TP.

J Immunol. 2010 Jan 15;184(2):658-65. doi: 10.4049/jimmunol.0903414.


HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.

Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA.

Diabetes. 2011 Jun;60(6):1726-33. doi: 10.2337/db10-1287.


In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.

Jarchum I, Baker JC, Yamada T, Takaki T, Marron MP, Serreze DV, DiLorenzo TP.

Diabetes. 2007 Oct;56(10):2551-60.


Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice.

Enée E, Martinuzzi E, Blancou P, Bach JM, Mallone R, van Endert P.

J Immunol. 2008 Apr 15;180(8):5430-8.


Identification of novel IGRP epitopes targeted in type 1 diabetes patients.

Jarchum I, Nichol L, Trucco M, Santamaria P, DiLorenzo TP.

Clin Immunol. 2008 Jun;127(3):359-65. doi: 10.1016/j.clim.2008.01.015.


Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.

Babad J, Mukherjee G, Follenzi A, Ali R, Roep BO, Shultz LD, Santamaria P, Yang OO, Goldstein H, Greiner DL, DiLorenzo TP.

Clin Exp Immunol. 2015 Mar;179(3):398-413. doi: 10.1111/cei.12465.


Regulatory CD8+ T cells induced by exposure to all-trans retinoic acid and TGF-beta suppress autoimmune diabetes.

Kishi M, Yasuda H, Abe Y, Sasaki H, Shimizu M, Arai T, Okumachi Y, Moriyama H, Hara K, Yokono K, Nagata M.

Biochem Biophys Res Commun. 2010 Mar 26;394(1):228-32. doi: 10.1016/j.bbrc.2010.02.176.


Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.

Alkemade GM, Clemente-Casares X, Yu Z, Xu BY, Wang J, Tsai S, Wright JR Jr, Roep BO, Santamaria P.

Diabetes. 2013 Mar;62(3):905-11. doi: 10.2337/db12-0600.


The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment.

Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R.

Diabetes. 2008 May;57(5):1312-20. doi: 10.2337/db07-1594.


IGRP and insulin vaccination induce CD8+ T cell-mediated autoimmune diabetes in the RIP-CD80GP mouse.

Fuchs YF, Adler K, Lindner A, Karasinsky A, Wilhelm C, Weigelt M, Balke H, Förtsch K, Mortler-Hildebrandt LF, Harlan DM, Pechhold K, Ziegler AG, Bonifacio E.

Clin Exp Immunol. 2014 May;176(2):199-206. doi: 10.1111/cei.12263.


Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes.

Antal Z, Baker JC, Smith C, Jarchum I, Babad J, Mukherjee G, Yang Y, Sidney J, Sette A, Santamaria P, DiLorenzo TP.

J Immunol. 2012 Jun 1;188(11):5766-75. doi: 10.4049/jimmunol.1102930.


Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

Krishnamurthy B, Dudek NL, McKenzie MD, Purcell AW, Brooks AG, Gellert S, Colman PG, Harrison LC, Lew AM, Thomas HE, Kay TW.

J Clin Invest. 2006 Dec;116(12):3258-65.

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