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Items: 1 to 20 of 168

1.

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.

Kubota Y, O'Grady P, Saito H, Takekawa M.

Nat Cell Biol. 2011 Mar;13(3):282-91. doi: 10.1038/ncb2169. Epub 2011 Feb 20.

PMID:
21336309
2.

SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.

Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y, Yu J, Huang J.

Mol Cancer. 2014 Apr 29;13:95. doi: 10.1186/1476-4598-13-95.

3.
4.

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA.

Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7. Review.

5.

Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway.

Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M.

Mol Cell Biol. 2001 May;21(9):3192-205.

6.

Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.

Jeon SH, Yoon JY, Park YN, Jeong WJ, Kim S, Jho EH, Surh YJ, Choi KY.

J Biol Chem. 2007 May 11;282(19):14482-92. Epub 2007 Mar 20.

7.

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

Vasudevan KM, Burikhanov R, Goswami A, Rangnekar VM.

Cancer Res. 2007 Nov 1;67(21):10343-50.

8.

Bromodomain containing protein represses the Ras/Raf/MEK/ERK pathway to attenuate human hepatoma cell proliferation during HCV infection.

Zhang Q, Wei L, Yang H, Yang W, Yang Q, Zhang Z, Wu K, Wu J.

Cancer Lett. 2016 Feb 1;371(1):107-16. doi: 10.1016/j.canlet.2015.11.027. Epub 2015 Nov 24.

9.

Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation.

Ikenoue T, Hikiba Y, Kanai F, Aragaki J, Tanaka Y, Imamura J, Imamura T, Ohta M, Ijichi H, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2004 May 15;64(10):3428-35.

10.
11.

MEK in cancer and cancer therapy.

Neuzillet C, Tijeras-Raballand A, de Mestier L, Cros J, Faivre S, Raymond E.

Pharmacol Ther. 2014 Feb;141(2):160-71. doi: 10.1016/j.pharmthera.2013.10.001. Epub 2013 Oct 9. Review.

PMID:
24121058
13.

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.

Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, Regl G, Kroismayr R, Moriggl R, Sibilia M, Aberger F.

Cancer Res. 2009 Feb 15;69(4):1284-92. doi: 10.1158/0008-5472.CAN-08-2331. Epub 2009 Feb 3.

14.

Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells.

Arthan D, Hong SK, Park JI.

Cancer Lett. 2010 Nov 1;297(1):31-41. doi: 10.1016/j.canlet.2010.04.021. Epub 2010 May 31.

PMID:
20570039
17.

Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.

Plattner R, Gupta S, Khosravi-Far R, Sato KY, Perucho M, Der CJ, Stanbridge EJ.

Oncogene. 1999 Mar 11;18(10):1807-17.

18.

KSR regulation of the Raf-MEK-ERK cascade.

Ritt DA, Daar IO, Morrison DK.

Methods Enzymol. 2006;407:224-37.

PMID:
16757327
19.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3.

PMID:
20130576
20.

CrkL plays a role in SDF-1-induced activation of the Raf-1/MEK/Erk pathway through Ras and Rac to mediate chemotactic signaling in hematopoietic cells.

Arai A, Aoki M, Weihua Y, Jin A, Miura O.

Cell Signal. 2006 Dec;18(12):2162-71. Epub 2006 May 16.

PMID:
16781119

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