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Items: 1 to 20 of 86

1.

Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription.

Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G.

Nat Struct Mol Biol. 2011 Mar;18(3):372-8. doi: 10.1038/nsmb.1993. Epub 2011 Feb 20.

PMID:
21336277
2.

Chromatin structure, epigenetic mechanisms and long-range interactions in the human insulin locus.

Xu Z, Lefevre GM, Felsenfeld G.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:1-11. doi: 10.1111/j.1463-1326.2012.01645.x. Review.

PMID:
22928559
3.

Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.

Xu Z, Lefevre GM, Gavrilova O, Foster St Claire MB, Riddick G, Felsenfeld G.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16760-5. doi: 10.1073/pnas.1419240111. Epub 2014 Nov 10.

4.

Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element.

Pino MF, Ye DZ, Linning KD, Green CD, Wicksteed B, Poitout V, Olson LK.

Mol Endocrinol. 2005 May;19(5):1343-60. Epub 2005 Jan 13.

PMID:
15650027
7.

Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells.

Thomas MK, Lee JH, Rastalsky N, Habener JF.

Endocrinology. 2001 Mar;142(3):1033-40.

PMID:
11181516
8.

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.

Lawrence MC, McGlynn K, Park BH, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26751-9. Epub 2005 May 16.

9.

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, Takayasu S, Kojima N, Iwasaki S, Ohashi R, Jiang S, Hasegawa G, Ioka RX, Magoori K, Sumi K, Maejima T, Uchida A, Naito M, Osborne TF, Yanagisawa M, Yamamoto TT, Kodama T, Sakai J.

J Biol Chem. 2005 Nov 11;280(45):37669-80. Epub 2005 Sep 7.

11.

Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.

Seo HY, Kim YD, Lee KM, Min AK, Kim MK, Kim HS, Won KC, Park JY, Lee KU, Choi HS, Park KG, Lee IK.

Endocrinology. 2008 Aug;149(8):3832-41. doi: 10.1210/en.2008-0015. Epub 2008 May 1.

12.

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.

Seufert J, Kieffer TJ, Habener JF.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):674-9.

13.
15.

Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription.

Huang L, Yan M, Kirschke CP.

Exp Cell Res. 2010 Oct 1;316(16):2630-43. doi: 10.1016/j.yexcr.2010.06.017. Epub 2010 Jul 1.

PMID:
20599947
16.

Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells.

Raile K, Klammt J, Garten A, Laue S, Blüher M, Kralisch S, Klöting N, Kiess W.

Regul Pept. 2006 Jul 15;135(1-2):30-8. Epub 2006 Apr 27.

PMID:
16644033
17.

The bile acid sensor FXR regulates insulin transcription and secretion.

Renga B, Mencarelli A, Vavassori P, Brancaleone V, Fiorucci S.

Biochim Biophys Acta. 2010 Mar;1802(3):363-72. doi: 10.1016/j.bbadis.2010.01.002. Epub 2010 Jan 7.

18.

Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate.

Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, Gong B, Wang L, Guo H, Xin W, Zhao J, Gao L.

Endocrinology. 2008 Feb;149(2):662-71. Epub 2007 Nov 8.

PMID:
17991720
19.

Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells.

Lawrence MC, Bhatt HS, Watterson JM, Easom RA.

Mol Endocrinol. 2001 Oct;15(10):1758-67.

PMID:
11579208
20.

Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation.

Omori K, Mitsuhashi M, Todorov I, Rawson J, Shiang KD, Kandeel F, Mullen Y.

Transplantation. 2010 Jan 27;89(2):146-54. doi: 10.1097/TP.0b013e3181c4218d.

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