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Items: 1 to 20 of 106

1.

Binding of small molecules to cavity forming mutants of a de novo designed protein.

Das A, Wei Y, Pelczer I, Hecht MH.

Protein Sci. 2011 Apr;20(4):702-11. doi: 10.1002/pro.601. Epub 2011 Mar 7.

2.

Solution structure of a de novo protein from a designed combinatorial library.

Wei Y, Kim S, Fela D, Baum J, Hecht MH.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13270-3. Epub 2003 Oct 30.

3.

Stably folded de novo proteins from a designed combinatorial library.

Wei Y, Liu T, Sazinsky SL, Moffet DA, Pelczer I, Hecht MH.

Protein Sci. 2003 Jan;12(1):92-102.

4.

De novo proteins from designed combinatorial libraries.

Hecht MH, Das A, Go A, Bradley LH, Wei Y.

Protein Sci. 2004 Jul;13(7):1711-23. Review.

5.

Enzyme-like proteins from an unselected library of designed amino acid sequences.

Wei Y, Hecht MH.

Protein Eng Des Sel. 2004 Jan;17(1):67-75.

PMID:
14985539
6.

Proteins from an unevolved library of de novo designed sequences bind a range of small molecules.

Cherny I, Korolev M, Koehler AN, Hecht MH.

ACS Synth Biol. 2012 Apr 20;1(4):130-8. doi: 10.1021/sb200018e. Epub 2012 Apr 2.

7.

Hydrophobic core malleability of a de novo designed three-helix bundle protein.

Walsh ST, Sukharev VI, Betz SF, Vekshin NL, DeGrado WF.

J Mol Biol. 2001 Jan 12;305(2):361-73.

PMID:
11124911
8.
9.

Computational de novo design of a four-helix bundle protein--DND_4HB.

Murphy GS, Sathyamoorthy B, Der BS, Machius MC, Pulavarti SV, Szyperski T, Kuhlman B.

Protein Sci. 2015 Apr;24(4):434-45. doi: 10.1002/pro.2577. Epub 2014 Nov 6.

10.

Structure and dynamics of de novo proteins from a designed superfamily of 4-helix bundles.

Go A, Kim S, Baum J, Hecht MH.

Protein Sci. 2008 May;17(5):821-32. doi: 10.1110/ps.073377908.

11.

De novo backbone and sequence design of an idealized alpha/beta-barrel protein: evidence of stable tertiary structure.

Offredi F, Dubail F, Kischel P, Sarinski K, Stern AS, Van de Weerdt C, Hoch JC, Prosperi C, François JM, Mayo SL, Martial JA.

J Mol Biol. 2003 Jan 3;325(1):163-74.

12.

Ab initio prediction of the three-dimensional structure of a de novo designed protein: a double-blind case study.

Klepeis JL, Wei Y, Hecht MH, Floudas CA.

Proteins. 2005 Feb 15;58(3):560-70.

PMID:
15609306
13.

Dynamics of a de novo designed three-helix bundle protein studied by 15N, 13C, and 2H NMR relaxation methods.

Walsh ST, Lee AL, DeGrado WF, Wand AJ.

Biochemistry. 2001 Aug 14;40(32):9560-9.

PMID:
11583155
14.

Protein design by binary patterning of polar and nonpolar amino acids.

Kamtekar S, Schiffer JM, Xiong H, Babik JM, Hecht MH.

Science. 1993 Dec 10;262(5140):1680-5.

PMID:
8259512
15.

Construction of proteins with molecular recognition capabilities using α3β3 de novo protein scaffolds.

Okura H, Mihara H, Takahashi T.

Protein Eng Des Sel. 2013 Oct;26(10):705-11. doi: 10.1093/protein/gzt046. Epub 2013 Sep 17.

PMID:
24046439
16.

Selection and structural analysis of de novo proteins from an alpha3beta3 genetic library.

Jumawid MT, Takahashi T, Yamazaki T, Ashigai H, Mihara H.

Protein Sci. 2009 Feb;18(2):384-98. doi: 10.1002/pro.41.

17.

De novo proteins from binary-patterned combinatorial libraries.

Bradley LH, Thumfort PP, Hecht MH.

Methods Mol Biol. 2006;340:53-69. Review.

PMID:
16957332
18.

A designed cavity in the hydrophobic core of a four-alpha-helix bundle improves volatile anesthetic binding affinity.

Johansson JS, Gibney BR, Rabanal F, Reddy KS, Dutton PL.

Biochemistry. 1998 Feb 3;37(5):1421-9.

PMID:
9477971
19.

High-quality combinatorial protein libraries using the binary patterning approach.

Bradley LH.

Methods Mol Biol. 2014;1216:117-28. doi: 10.1007/978-1-4939-1486-9_6. Review.

PMID:
25213413
20.

Design, expression, and initial characterization of MB1, a de novo protein enriched in essential amino acids.

Beauregard M, Dupont C, Teather RM, Hefford MA.

Biotechnology (N Y). 1995 Sep;13(9):974-81.

PMID:
9636274

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