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Items: 1 to 20 of 134

1.

CDK8: a positive regulator of transcription.

Galbraith MD, Donner AJ, Espinosa JM.

Transcription. 2010 Jul-Aug;1(1):4-12. doi: 10.4161/trns.1.1.12373. Review.

2.

Identification of target genes for the CDK subunits of the Mediator complex.

Tsutsui T, Fukasawa R, Tanaka A, Hirose Y, Ohkuma Y.

Genes Cells. 2011 Dec;16(12):1208-18. doi: 10.1111/j.1365-2443.2011.01565.x.

3.

Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.

Belakavadi M, Fondell JD.

Mol Cell Biol. 2010 May;30(10):2437-48. doi: 10.1128/MCB.01541-09. Epub 2010 Mar 15.

4.

Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.

Tsutsui T, Fukasawa R, Shinmyouzu K, Nakagawa R, Tobe K, Tanaka A, Ohkuma Y.

J Biol Chem. 2013 Jul 19;288(29):20955-65. doi: 10.1074/jbc.M113.486746. Epub 2013 Jun 9.

5.

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.

Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ.

Mol Cell Biol. 2017 Jun 15;37(13). pii: e00626-16. doi: 10.1128/MCB.00626-16. Print 2017 Jul 1.

6.

Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

Yamamoto S, Hagihara T, Horiuchi Y, Okui A, Wani S, Yoshida T, Inoue T, Tanaka A, Ito T, Hirose Y, Ohkuma Y.

Genes Cells. 2017 Mar;22(3):265-276. doi: 10.1111/gtc.12475. Epub 2017 Feb 2.

7.

A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation.

Furumoto T, Tanaka A, Ito M, Malik S, Hirose Y, Hanaoka F, Ohkuma Y.

Genes Cells. 2007 Jan;12(1):119-32.

8.

The two faces of Cdk8, a positive/negative regulator of transcription.

Nemet J, Jelicic B, Rubelj I, Sopta M.

Biochimie. 2014 Feb;97:22-7. doi: 10.1016/j.biochi.2013.10.004. Epub 2013 Oct 15. Review.

PMID:
24139904
9.

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.

Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM.

Cell. 2013 Jun 6;153(6):1327-39. doi: 10.1016/j.cell.2013.04.048.

10.

CDK8 is a stimulus-specific positive coregulator of p53 target genes.

Donner AJ, Szostek S, Hoover JM, Espinosa JM.

Mol Cell. 2007 Jul 6;27(1):121-33.

11.

CDK8 is a positive regulator of transcriptional elongation within the serum response network.

Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM.

Nat Struct Mol Biol. 2010 Feb;17(2):194-201. doi: 10.1038/nsmb.1752. Epub 2010 Jan 24.

12.

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Davis MA, Larimore EA, Fissel BM, Swanger J, Taatjes DJ, Clurman BE.

Genes Dev. 2013 Jan 15;27(2):151-6. doi: 10.1101/gad.207720.112. Epub 2013 Jan 15.

13.

Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Drogat J, Migeot V, Mommaerts E, Mullier C, Dieu M, van Bakel H, Hermand D.

Cell Rep. 2012 Nov 29;2(5):1068-76. doi: 10.1016/j.celrep.2012.09.027. Epub 2012 Nov 1.

14.

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

Gonzalez D, Hamidi N, Del Sol R, Benschop JJ, Nancy T, Li C, Francis L, Tzouros M, Krijgsveld J, Holstege FC, Conlan RS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2500-5. doi: 10.1073/pnas.1307525111. Epub 2014 Feb 3.

15.

CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation.

Zhao J, Ramos R, Demma M.

Oncogene. 2013 Jul 25;32(30):3520-30. doi: 10.1038/onc.2012.364. Epub 2012 Sep 3.

PMID:
22945643
16.

The Mediator complex and transcription regulation.

Poss ZC, Ebmeier CC, Taatjes DJ.

Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3. Review.

17.

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

Turunen M, Spaeth JM, Keskitalo S, Park MJ, Kivioja T, Clark AD, Mäkinen N, Gao F, Palin K, Nurkkala H, Vähärautio A, Aavikko M, Kämpjärvi K, Vahteristo P, Kim CA, Aaltonen LA, Varjosalo M, Taipale J, Boyer TG.

Cell Rep. 2014 May 8;7(3):654-60. doi: 10.1016/j.celrep.2014.03.047. Epub 2014 Apr 18.

18.

Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.

Law MJ, Ciccaglione K.

Genetics. 2015 Feb;199(2):435-53. doi: 10.1534/genetics.114.172841. Epub 2014 Dec 1.

19.

CYCLIN-DEPENDENT KINASE8 differentially regulates plant immunity to fungal pathogens through kinase-dependent and -independent functions in Arabidopsis.

Zhu Y, Schluttenhoffer CM, Wang P, Fu F, Thimmapuram J, Zhu JK, Lee SY, Yun DJ, Mengiste T.

Plant Cell. 2014 Oct;26(10):4149-70. doi: 10.1105/tpc.114.128611. Epub 2014 Oct 3.

20.

Mediator kinase module and human tumorigenesis.

Clark AD, Oldenbroek M, Boyer TG.

Crit Rev Biochem Mol Biol. 2015;50(5):393-426. doi: 10.3109/10409238.2015.1064854. Epub 2015 Jul 16. Review.

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