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Items: 1 to 20 of 103


Investigation of anticholinergic and non-steroidal anti-inflammatory prodrugs which reduce chemically induced skin inflammation.

Young SC, Fabio KM, Huang MT, Saxena J, Harman MP, Guillon CD, Vetrano AM, Heck DE, Flowers RA 2nd, Heindel ND, Laskin JD.

J Appl Toxicol. 2012 Feb;32(2):135-41. doi: 10.1002/jat.1645. Epub 2011 Feb 11.


Systemic administration of candidate antivesicants to protect against topically applied sulfur mustard in the mouse ear vesicant model (MEVM).

Babin MC, Ricketts K, Skvorak JP, Gazaway M, Mitcheltree LW, Casillas RP.

J Appl Toxicol. 2000 Dec;20 Suppl 1:S141-4.


Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin.

Jain AK, Tewari-Singh N, Gu M, Inturi S, White CW, Agarwal R.

Toxicol Lett. 2011 Sep 10;205(3):293-301. doi: 10.1016/j.toxlet.2011.06.019. Epub 2011 Jun 21.


Potential anti-inflammatory treatments against cutaneous sulfur mustard injury using the mouse ear vesicant model.

Dachir S, Fishbeine E, Meshulam Y, Sahar R, Amir A, Kadar T.

Hum Exp Toxicol. 2002 Apr;21(4):197-203.


Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide.

Black AT, Joseph LB, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):352-60. doi: 10.1016/j.taap.2010.04.001. Epub 2010 Apr 9.


Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice.

Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R.

Toxicol Sci. 2009 Mar;108(1):194-206. doi: 10.1093/toxsci/kfn261. Epub 2008 Dec 15.


Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction.

Young S, Fabio K, Guillon C, Mohanta P, Halton TA, Heck DE, Flowers RA 2nd, Laskin JD, Heindel ND.

Bioorg Med Chem Lett. 2010 May 1;20(9):2987-90. doi: 10.1016/j.bmcl.2010.02.102. Epub 2010 Mar 3.


Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.

Tewari-Singh N, Jain AK, Inturi S, Agarwal C, White CW, Agarwal R.

PLoS One. 2012;7(9):e46149. doi: 10.1371/journal.pone.0046149. Epub 2012 Sep 27.


Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review.

Qandil AM.

Int J Mol Sci. 2012 Dec 17;13(12):17244-74. doi: 10.3390/ijms131217244. Review.


Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID.

Dachir S, Fishbeine E, Meshulam Y, Sahar R, Chapman S, Amir A, Kadar T.

J Appl Toxicol. 2004 Mar-Apr;24(2):107-13.


Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard.

Chang YC, Wang JD, Hahn RA, Gordon MK, Joseph LB, Heck DE, Heindel ND, Young SC, Sinko PJ, Casillas RP, Laskin JD, Laskin DL, Gerecke DR.

Toxicol Appl Pharmacol. 2014 Oct 15;280(2):236-44. doi: 10.1016/j.taap.2014.07.016. Epub 2014 Aug 13.


Ameliorating effect of S-2(ω-aminoalkylamino) alkylaryl sulfide (DRDE-07) on sulfur mustard analogue, 2-chloroethyl ethyl sulfide-induced oxidative stress and inflammation.

Sawale SD, Ambhore PD, Pawar PP, Pathak U, Deb U, Satpute RM.

Toxicol Mech Methods. 2013 Nov;23(9):702-10. doi: 10.3109/15376516.2013.843109. Epub 2013 Oct 28.


Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects.

Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, Agarwal R, Day BJ.

Free Radic Biol Med. 2014 Jul;72:285-95. doi: 10.1016/j.freeradbiomed.2014.04.022. Epub 2014 May 9.


Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

Black AT, Hayden PJ, Casillas RP, Heck DE, Gerecke DR, Sinko PJ, Laskin DL, Laskin JD.

Toxicol Appl Pharmacol. 2010 Dec 1;249(2):178-87. doi: 10.1016/j.taap.2010.09.005. Epub 2010 Sep 16.


2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

Boulware S, Fields T, McIvor E, Powell KL, Abel EL, Vasquez KM, MacLeod MC.

Toxicol Appl Pharmacol. 2012 Sep 1;263(2):203-9. doi: 10.1016/j.taap.2012.06.010. Epub 2012 Jun 23.


2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin.

Jain AK, Tewari-Singh N, Orlicky DJ, White CW, Agarwal R.

Toxicology. 2011 Apr 11;282(3):129-38. doi: 10.1016/j.tox.2011.01.021. Epub 2011 Feb 2.


Mustard vesicants alter expression of the endocannabinoid system in mouse skin.

Wohlman IM, Composto GM, Heck DE, Heindel ND, Lacey CJ, Guillon CD, Casillas RP, Croutch CR, Gerecke DR, Laskin DL, Joseph LB, Laskin JD.

Toxicol Appl Pharmacol. 2016 Jul 15;303:30-44. doi: 10.1016/j.taap.2016.04.014. Epub 2016 Apr 26.


Protective effect of topical iodine containing anti-inflammatory drugs against sulfur mustard-induced skin lesions.

Wormser U, Sintov A, Brodsky B, Casillas RP, Nyska A.

Arch Toxicol. 2004 Mar;78(3):156-66. Epub 2003 Nov 15.


Ocular injuries following sulfur mustard exposure--pathological mechanism and potential therapy.

Kadar T, Dachir S, Cohen L, Sahar R, Fishbine E, Cohen M, Turetz J, Gutman H, Buch H, Brandeis R, Horwitz V, Solomon A, Amir A.

Toxicology. 2009 Sep 1;263(1):59-69. doi: 10.1016/j.tox.2008.10.026. Epub 2008 Nov 17.


Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning.

Amitai G, Adani R, Fishbein E, Meshulam H, Laish I, Dachir S.

J Appl Toxicol. 2006 Jan-Feb;26(1):81-7.


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