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Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog.

Lindgren AG, Natsuhara K, Tian E, Vincent JJ, Li X, Jiao J, Wu H, Banerjee U, Clark AT.

PLoS One. 2011 Jan 27;6(1):e16478. doi: 10.1371/journal.pone.0016478.


Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.

Alva JA, Lee GE, Escobar EE, Pyle AD.

Stem Cells. 2011 Dec;29(12):1952-62. doi: 10.1002/stem.748.


Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma.

Shan J, Shen J, Liu L, Xia F, Xu C, Duan G, Xu Y, Ma Q, Yang Z, Zhang Q, Ma L, Liu J, Xu S, Yan X, Bie P, Cui Y, Bian XW, Qian C.

Hepatology. 2012 Sep;56(3):1004-14. doi: 10.1002/hep.25745. Epub 2012 Jul 12.


Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/- prostate cancer model.

Abou-Kheir WG, Hynes PG, Martin PL, Pierce R, Kelly K.

Stem Cells. 2010 Dec;28(12):2129-40. doi: 10.1002/stem.538.


Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells.

Gaspar JA, Doss MX, Winkler J, Wagh V, Hescheler J, Kolde R, Vilo J, Schulz H, Sachinidis A.

Stem Cells Dev. 2012 Sep 1;21(13):2471-84. doi: 10.1089/scd.2011.0637. Epub 2012 Apr 17.


Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA.

Cold Spring Harb Symp Quant Biol. 2008;73:427-37. doi: 10.1101/sqb.2008.73.047. Epub 2009 Jan 15.


Self-renewal of teratocarcinoma and embryonic stem cells.

Chambers I, Smith A.

Oncogene. 2004 Sep 20;23(43):7150-60. Review.


Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.

Villasante A, Piazzolla D, Li H, Gomez-Lopez G, Djabali M, Serrano M.

Cell Cycle. 2011 May 1;10(9):1488-98. Epub 2011 May 1.


Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages.

Hyslop L, Stojkovic M, Armstrong L, Walter T, Stojkovic P, Przyborski S, Herbert M, Murdoch A, Strachan T, Lako M.

Stem Cells. 2005 Sep;23(8):1035-43. Epub 2005 Jun 27.


Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.

Das S, Jena S, Levasseur DN.

J Biol Chem. 2011 Dec 9;286(49):42690-703. doi: 10.1074/jbc.M111.290189. Epub 2011 Oct 3.


Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells.

Mandal S, Lindgren AG, Srivastava AS, Clark AT, Banerjee U.

Stem Cells. 2011 Mar;29(3):486-95. doi: 10.1002/stem.590.


NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

Siddique HR, Feldman DE, Chen CL, Punj V, Tokumitsu H, Machida K.

Hepatology. 2015 Nov;62(5):1466-79. doi: 10.1002/hep.27987. Epub 2015 Aug 28.


Spheroid body-forming cells in the human gastric cancer cell line MKN-45 possess cancer stem cell properties.

Liu J, Ma L, Xu J, Liu C, Zhang J, Liu J, Chen R, Zhou Y.

Int J Oncol. 2013 Feb;42(2):453-9. doi: 10.3892/ijo.2012.1720. Epub 2012 Nov 29.


Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies.

Lee AS, Tang C, Rao MS, Weissman IL, Wu JC.

Nat Med. 2013 Aug;19(8):998-1004. doi: 10.1038/nm.3267. Epub 2013 Aug 6. Review.


Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers.

Hoei-Hansen CE, Kraggerud SM, Abeler VM, Kaern J, Rajpert-De Meyts E, Lothe RA.

Mol Cancer. 2007 Feb 2;6:12.


TGF-β-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium.

Galvin-Burgess KE, Travis ED, Pierson KE, Vivian JL.

Stem Cells. 2013 Jan;31(1):48-58. doi: 10.1002/stem.1252.


PTEN and TRP53 independently suppress Nanog expression in spermatogonial stem cells.

Kuijk EW, van Mil A, Brinkhof B, Penning LC, Colenbrander B, Roelen BA.

Stem Cells Dev. 2010 Jul;19(7):979-88. doi: 10.1089/scd.2009.0276.


Promotion of feeder-independent self-renewal of embryonic stem cells by retinol (vitamin A).

Chen L, Khillan JS.

Stem Cells. 2008 Jul;26(7):1858-64. doi: 10.1634/stemcells.2008-0050. Epub 2008 Apr 24.


The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage.

Elatmani H, Dormoy-Raclet V, Dubus P, Dautry F, Chazaud C, Jacquemin-Sablon H.

Stem Cells. 2011 Oct;29(10):1504-16. doi: 10.1002/stem.712.


Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.

Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY.

Hepatology. 2012 Dec;56(6):2255-67. doi: 10.1002/hep.26007.


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