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Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.

Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV.

Mol Neurodegener. 2011 Feb 3;6:13. doi: 10.1186/1750-1326-6-13.


Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV.

J Neurosci. 2010 Nov 17;30(46):15521-34. doi: 10.1523/JNEUROSCI.4437-10.2010.


Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV.

Nat Med. 2004 Dec;10(12):1379-83. Epub 2004 Oct 31.


Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV.

Blood. 2010 Jun 10;115(23):4963-72. doi: 10.1182/blood-2010-01-262386. Epub 2010 Mar 26.


Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway.

Wu F, Echeverry R, Wu J, An J, Haile WB, Cooper DS, Catano M, Yepes M.

Mol Cell Neurosci. 2013 Jan;52:9-19. doi: 10.1016/j.mcn.2012.10.001. Epub 2012 Oct 9.


Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity.

Lopez-Atalaya JP, Roussel BD, Levrat D, Parcq J, Nicole O, Hommet Y, Benchenane K, Castel H, Leprince J, To Van D, Bureau R, Rault S, Vaudry H, Petersen KU, Santos JS, Ali C, Vivien D.

J Cereb Blood Flow Metab. 2008 Jun;28(6):1212-21. doi: 10.1038/jcbfm.2008.14. Epub 2008 Mar 12.


Inhibition of N-methyl-D-aspartate receptors increases paraoxon-induced apoptosis in cultured neurons.

Wu X, Tian F, Okagaki P, Marini AM.

Toxicol Appl Pharmacol. 2005 Oct 1;208(1):57-67.


Tissue Plasminogen Activator Neurotoxicity is Neutralized by Recombinant ADAMTS 13.

Fan M, Xu H, Wang L, Luo H, Zhu X, Cai P, Wei L, Lu L, Cao Y, Ye R, Fan W, Zhao BQ.

Sci Rep. 2016 May 16;6:25971. doi: 10.1038/srep25971.


Neuroserpin protects neurons from ischemia-induced plasmin-mediated cell death independently of tissue-type plasminogen activator inhibition.

Wu J, Echeverry R, Guzman J, Yepes M.

Am J Pathol. 2010 Nov;177(5):2576-84. doi: 10.2353/ajpath.2010.100466. Epub 2010 Sep 23.


Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.

Echeverry R, Wu J, Haile WB, Guzman J, Yepes M.

J Clin Invest. 2010 Jun;120(6):2194-205. doi: 10.1172/JCI41722. Epub 2010 May 3.


Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect.

Jantas D, Lason W.

Neurochem Res. 2009 Nov;34(11):2040-54. doi: 10.1007/s11064-009-9991-y. Epub 2009 May 22.


Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke.

Zhang Z, Zhang L, Yepes M, Jiang Q, Li Q, Arniego P, Coleman TA, Lawrence DA, Chopp M.

Circulation. 2002 Aug 6;106(6):740-5.


Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

Gabriel C, Ali C, Lesné S, Fernández-Monreal M, Docagne F, Plawinski L, MacKenzie ET, Buisson A, Vivien D.

FASEB J. 2003 Feb;17(2):277-9. Epub 2002 Dec 17.


Comparison between single and combined post-treatment with S-Methyl-N,N-diethylthiolcarbamate sulfoxide and taurine following transient focal cerebral ischemia in rat brain.

Gharibani P, Modi J, Menzie J, Alexandrescu A, Ma Z, Tao R, Prentice H, Wu JY.

Neuroscience. 2015 Aug 6;300:460-73. doi: 10.1016/j.neuroscience.2015.05.042. Epub 2015 May 27.


The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo.

Lebeurrier N, Liot G, Lopez-Atalaya JP, Orset C, Fernandez-Monreal M, Sonderegger P, Ali C, Vivien D.

Mol Cell Neurosci. 2005 Dec;30(4):552-8. Epub 2005 Oct 4.


Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid β-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway.

Zeng KW, Wang XM, Ko H, Kwon HC, Cha JW, Yang HO.

Eur J Pharmacol. 2011 Dec 15;672(1-3):45-55. doi: 10.1016/j.ejphar.2011.09.177. Epub 2011 Sep 29.


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