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Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.

Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK.

Hepatology. 2011 Feb;53(2):587-95. doi: 10.1002/hep.24040. Epub 2011 Jan 6. Erratum in: Hepatology. 2014 Aug;60(2):771.


Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration.

Donthamsetty S, Bowen W, Mars W, Bhave V, Luo JH, Wu C, Hurd J, Orr A, Bell A, Michalopoulos G.

Toxicol Sci. 2010 Feb;113(2):358-66. doi: 10.1093/toxsci/kfp281. Epub 2009 Nov 17.


Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.

Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK.

Hepatology. 2008 Dec;48(6):1932-41. doi: 10.1002/hep.22537.


C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.

Blanco-Bose WE, Murphy MJ, Ehninger A, Offner S, Dubey C, Huang W, Moore DD, Trumpp A.

Hepatology. 2008 Oct;48(4):1302-11. doi: 10.1002/hep.22475.


Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.

Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK.

Hepatology. 2009 Sep;50(3):844-51. doi: 10.1002/hep.23059.


Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice.

Lin CW, Mars WM, Paranjpe S, Donthamsetty S, Bhave VS, Kang LI, Orr A, Bowen WC, Bell AW, Michalopoulos GK.

Hepatology. 2011 Aug;54(2):620-30. doi: 10.1002/hep.24417. Erratum in: Hepatology. 2014 Sep;60(3):1116.


Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis.

Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK.

Hepatology. 2007 Apr;45(4):1025-34.


Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

Baskin-Bey ES, Huang W, Ishimura N, Isomoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ.

Hepatology. 2006 Jul;44(1):252-62.


Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation.

Braeuning A, Heubach Y, Knorpp T, Kowalik MA, Templin M, Columbano A, Schwarz M.

Toxicol Sci. 2011 Sep;123(1):113-22. doi: 10.1093/toxsci/kfr166. Epub 2011 Jun 24.


Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.


Expression of c-jun is not mandatory for mouse hepatocyte proliferation induced by two nuclear receptor ligands: TCPOBOP and T3.

Leoni VP, Ledda-Columbano GM, Pibiri M, Saliba C, Perra A, Kowalik MA, Grober OM, Ravo M, Weisz A, Locker J, Ghiso E, Giordano S, Columbano A.

J Hepatol. 2011 Nov;55(5):1069-78. doi: 10.1016/j.jhep.2011.02.016. Epub 2011 Feb 25.


Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice.

Kowalik MA, Saliba C, Pibiri M, Perra A, Ledda-Columbano GM, Sarotto I, Ghiso E, Giordano S, Columbano A.

Hepatology. 2011 Jun;53(6):2086-96. doi: 10.1002/hep.24289. Epub 2011 May 13.


Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.

Donthamsetty S, Bhave VS, Mars WM, Bowen WC, Orr A, Haynes MM, Wu C, Michalopoulos GK.

PLoS One. 2013 Sep 18;8(9):e74625. doi: 10.1371/journal.pone.0074625. eCollection 2013.


SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism.

Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Xu J, Yu C.

J Hepatol. 2012 Jan;56(1):210-7. doi: 10.1016/j.jhep.2011.07.015. Epub 2011 Aug 7.


The time point of β-catenin knockout in hepatocytes determines their response to xenobiotic activation of the constitutive androstane receptor.

Ganzenberg K, Singh Y, Braeuning A.

Toxicology. 2013 Jun 7;308:113-21. doi: 10.1016/j.tox.2013.03.019. Epub 2013 Apr 8.


Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice.

Tian J, Huang H, Hoffman B, Liebermann DA, Ledda-Columbano GM, Columbano A, Locker J.

J Clin Invest. 2011 Nov;121(11):4491-502. doi: 10.1172/JCI38760. Epub 2011 Oct 3.


Integrin-linked kinase is involved in matrix-induced hepatocyte differentiation.

Gkretsi V, Bowen WC, Yang Y, Wu C, Michalopoulos GK.

Biochem Biophys Res Commun. 2007 Feb 16;353(3):638-43. Epub 2006 Dec 20.


Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia.

Columbano A, Ledda-Columbano GM, Pibiri M, Cossu C, Menegazzi M, Moore DD, Huang W, Tian J, Locker J.

Hepatology. 2005 Nov;42(5):1118-26.


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