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Soluble guanylate cyclase-α1 is required for the cardioprotective effects of inhaled nitric oxide.

Nagasaka Y, Buys ES, Spagnolli E, Steinbicker AU, Hayton SR, Rauwerdink KM, Brouckaert P, Zapol WM, Bloch KD.

Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1477-83. doi: 10.1152/ajpheart.00948.2010. Epub 2011 Jan 21.


sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling.

Cawley SM, Kolodziej S, Ichinose F, Brouckaert P, Buys ES, Bloch KD.

Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H157-63. doi: 10.1152/ajpheart.01273.2010. Epub 2011 May 2.


Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.

Dhaese I, Vanneste G, Sips P, Buys E, Brouckaert P, Lefebvre RA.

Eur J Pharmacol. 2008 Jul 28;589(1-3):251-9. doi: 10.1016/j.ejphar.2008.05.021. Epub 2008 May 23.


Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms.

Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W.

Anesthesiology. 2011 Mar;114(3):603-13. doi: 10.1097/ALN.0b013e31820a4d5b.


Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.

Atochin DN, Yuzawa I, Li Q, Rauwerdink KM, Malhotra R, Chang J, Brouckaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL, Buys ES.

Stroke. 2010 Aug;41(8):1815-9. doi: 10.1161/STROKEAHA.109.577635. Epub 2010 Jul 1.


Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice.

Vanneste G, Dhaese I, Sips P, Buys E, Brouckaert P, Lefebvre RA.

J Physiol. 2007 Nov 1;584(Pt 3):907-20. Epub 2007 Aug 23.


Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.

Nimmegeers S, Sips P, Buys E, Brouckaert P, Van de Voorde J.

Cardiovasc Res. 2007 Oct 1;76(1):149-59. Epub 2007 Jun 12.


Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury.

Korkmaz S, Radovits T, Barnucz E, Hirschberg K, Neugebauer P, Loganathan S, Veres G, Páli S, Seidel B, Zöllner S, Karck M, Szabó G.

Circulation. 2009 Aug 25;120(8):677-86. doi: 10.1161/CIRCULATIONAHA.109.870774. Epub 2009 Aug 10.


Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition.

Fraccarollo D, Galuppo P, Motschenbacher S, Ruetten H, Schäfer A, Bauersachs J.

Basic Res Cardiol. 2014 Jul;109(4):421. doi: 10.1007/s00395-014-0421-1. Epub 2014 Jun 8.


Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.

Salloum FN, Das A, Samidurai A, Hoke NN, Chau VQ, Ockaili RA, Stasch JP, Kukreja RC.

Am J Physiol Heart Circ Physiol. 2012 Mar 15;302(6):H1347-54. doi: 10.1152/ajpheart.00544.2011. Epub 2012 Jan 20.


NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.

Bice JS, Keim Y, Stasch JP, Baxter GF.

Cardiovasc Res. 2014 Feb 1;101(2):220-8. doi: 10.1093/cvr/cvt257. Epub 2013 Nov 20.


In vitro and in vivo studies on the importance of the soluble guanylyl cyclase α1 subunit in penile erection.

Decaluwé K, Nimmegeers S, Thoonen R, Buys E, Brouckaert P, Van de Voorde J.

World J Urol. 2010 Oct;28(5):643-50. doi: 10.1007/s00345-010-0509-7. Epub 2010 Jan 23.


Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia.

Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S.

Circulation. 2007 Aug 21;116(8):936-43. Epub 2007 Aug 6.


The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning.

Sips PY, Brouckaert P, Ichinose F.

Basic Res Cardiol. 2011 Jun;106(4):635-43. doi: 10.1007/s00395-011-0167-y. Epub 2011 Mar 11.


Inhalation of NO during myocardial ischemia reduces infarct size and improves cardiac function.

Neye N, Enigk F, Shiva S, Habazettl H, Plesnila N, Kuppe H, Gladwin MT, Kuebler WM.

Intensive Care Med. 2012 Aug;38(8):1381-91. doi: 10.1007/s00134-012-2605-1. Epub 2012 Jun 1.


Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.

Wang WZ, Jones AW, Wang M, Durante W, Korthuis RJ.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H521-32. doi: 10.1152/ajpheart.00810.2012. Epub 2013 Jun 14.


CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mechanism.

Jujo K, Ii M, Sekiguchi H, Klyachko E, Misener S, Tanaka T, Tongers J, Roncalli J, Renault MA, Thorne T, Ito A, Clarke T, Kamide C, Tsurumi Y, Hagiwara N, Qin G, Asahi M, Losordo DW.

Circulation. 2013 Jan 1;127(1):63-73. doi: 10.1161/CIRCULATIONAHA.112.099242. Epub 2012 Nov 30.


Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart.

Shinbo T, Kokubo K, Sato Y, Hagiri S, Hataishi R, Hirose M, Kobayashi H.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H542-50. doi: 10.1152/ajpheart.00844.2012. Epub 2013 Jun 14.


Soluble guanylate cyclase modulates alveolarization in the newborn lung.

Bachiller PR, Cornog KH, Kato R, Buys ES, Roberts JD Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Oct 15;305(8):L569-81. doi: 10.1152/ajplung.00401.2012. Epub 2013 Aug 9.


Role of the soluble guanylyl cyclase alpha1-subunit in mice corpus cavernosum smooth muscle relaxation.

Nimmegeers S, Sips P, Buys E, Decaluwé K, Brouckaert P, Van de Voorde J.

Int J Impot Res. 2008 May-Jun;20(3):278-84. Epub 2007 Dec 6.


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