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Items: 1 to 20 of 103


Exploration of the cytochrome c oxidase pathway puzzle and examination of the origin of elusive mutational effects.

Chakrabarty S, Namslauer I, Brzezinski P, Warshel A.

Biochim Biophys Acta. 2011 Apr;1807(4):413-26. doi: 10.1016/j.bbabio.2011.01.004. Epub 2011 Jan 10.


Exploring pathways and barriers for coupled ET/PT in cytochrome c oxidase: a general framework for examining energetics and mechanistic alternatives.

Olsson MH, Siegbahn PE, Blomberg MR, Warshel A.

Biochim Biophys Acta. 2007 Mar;1767(3):244-60. Epub 2007 Jan 30.


A D-pathway mutation decouples the Paracoccus denitrificans cytochrome c oxidase by altering the side-chain orientation of a distant conserved glutamate.

Dürr KL, Koepke J, Hellwig P, Müller H, Angerer H, Peng G, Olkhova E, Richter OM, Ludwig B, Michel H.

J Mol Biol. 2008 Dec 26;384(4):865-77. doi: 10.1016/j.jmb.2008.09.074. Epub 2008 Oct 9.


Electrostatic basis for the unidirectionality of the primary proton transfer in cytochrome c oxidase.

Pisliakov AV, Sharma PK, Chu ZT, Haranczyk M, Warshel A.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7726-31. doi: 10.1073/pnas.0800580105. Epub 2008 May 28.


Microscopic pKa analysis of Glu286 in cytochrome c oxidase (Rhodobacter sphaeroides): toward a calibrated molecular model.

Ghosh N, Prat-Resina X, Gunner MR, Cui Q.

Biochemistry. 2009 Mar 24;48(11):2468-85. doi: 10.1021/bi8021284.


Analysis of the kinetics of the membrane potential generated by cytochrome c oxidase upon single electron injection.

Medvedev DM, Medvedev ES, Kotelnikov AI, Stuchebrukhov AA.

Biochim Biophys Acta. 2005 Nov 15;1710(1):47-56. Epub 2005 Oct 3.


Exploring the entrance of proton pathways in cytochrome c oxidase from Paracoccus denitrificans: surface charge, buffer capacity and redox-dependent polarity changes at the internal surface.

Kirchberg K, Michel H, Alexiev U.

Biochim Biophys Acta. 2013 Mar;1827(3):276-84. doi: 10.1016/j.bbabio.2012.10.014. Epub 2012 Oct 31.


Respiratory conservation of energy with dioxygen: cytochrome C oxidase.

Yoshikawa S, Shimada A, Shinzawa-Itoh K.

Met Ions Life Sci. 2015;15:89-130. doi: 10.1007/978-3-319-12415-5_4. Review.


Interconversions of P and F intermediates of cytochrome c oxidase from Paracoccus denitrificans.

von der Hocht I, van Wonderen JH, Hilbers F, Angerer H, MacMillan F, Michel H.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3964-9. doi: 10.1073/pnas.1100950108. Epub 2011 Feb 22.


Proton-transport mechanisms in cytochrome c oxidase revealed by studies of kinetic isotope effects.

Johansson AL, Chakrabarty S, Berthold CL, Högbom M, Warshel A, Brzezinski P.

Biochim Biophys Acta. 2011 Sep;1807(9):1083-94. doi: 10.1016/j.bbabio.2011.03.012. Epub 2011 Apr 2.


Tracing the D-pathway in reconstituted site-directed mutants of cytochrome c oxidase from Paracoccus denitrificans.

Pfitzner U, Hoffmeier K, Harrenga A, Kannt A, Michel H, Bamberg E, Richter OM, Ludwig B.

Biochemistry. 2000 Jun 13;39(23):6756-62.


Cytochrome c oxidase (heme aa3) from Paracoccus denitrificans: analysis of mutations in putative proton channels of subunit I.

Pfitzner U, Odenwald A, Ostermann T, Weingard L, Ludwig B, Richter OM.

J Bioenerg Biomembr. 1998 Feb;30(1):89-97. Review.


Cytochrome c oxidase: chemistry of a molecular machine.

Musser SM, Stowell MH, Chan SI.

Adv Enzymol Relat Areas Mol Biol. 1995;71:79-208. Review.


Similarity of cytochrome c oxidases in different organisms.

Popovic DM, Leontyev IV, Beech DG, Stuchebrukhov AA.

Proteins. 2010 Sep;78(12):2691-8. doi: 10.1002/prot.22783.


Intricate role of water in proton transport through cytochrome c oxidase.

Lee HJ, Svahn E, Swanson JM, Lepp H, Voth GA, Brzezinski P, Gennis RB.

J Am Chem Soc. 2010 Nov 17;132(45):16225-39. doi: 10.1021/ja107244g. Epub 2010 Oct 21.


Controlled uncoupling and recoupling of proton pumping in cytochrome c oxidase.

Brändén G, Pawate AS, Gennis RB, Brzezinski P.

Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):317-22. Epub 2006 Jan 3.


The role of the conserved tryptophan272 of the Paracoccus denitrificans cytochrome c oxidase in proton pumping.

de Vries S.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):925-8. doi: 10.1016/j.bbabio.2008.05.008. Epub 2008 May 20.


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