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The estrogen receptor α colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2.

de Souza FS, Nasif S, López-Leal R, Levi DH, Low MJ, Rubinsten M.

Eur J Pharmacol. 2011 Jun 11;660(1):181-7. doi: 10.1016/j.ejphar.2010.10.114. Epub 2011 Jan 3.


Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene.

Santangelo AM, de Souza FS, Franchini LF, Bumaschny VF, Low MJ, Rubinstein M.

PLoS Genet. 2007 Oct;3(10):1813-26.


Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting.

de Souza FS, Santangelo AM, Bumaschny V, Avale ME, Smart JL, Low MJ, Rubinstein M.

Mol Cell Biol. 2005 Apr;25(8):3076-86.


Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold.

Lam DD, de Souza FS, Nasif S, Yamashita M, López-Leal R, Otero-Corchon V, Meece K, Sampath H, Mercer AJ, Wardlaw SL, Rubinstein M, Low MJ.

PLoS Genet. 2015 Feb 11;11(2):e1004935. doi: 10.1371/journal.pgen.1004935. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 Apr;11(4):e1005133.


Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons.

Franchini LF, López-Leal R, Nasif S, Beati P, Gelman DM, Low MJ, de Souza FJ, Rubinstein M.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15270-5. doi: 10.1073/pnas.1104997108. Epub 2011 Aug 29. Erratum in: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20850.


Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.

Nasif S, de Souza FS, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1861-70. doi: 10.1073/pnas.1500672112. Epub 2015 Mar 30.


Enhancer turnover and conserved regulatory function in vertebrate evolution.

Domené S, Bumaschny VF, de Souza FS, Franchini LF, Nasif S, Low MJ, Rubinstein M.

Philos Trans R Soc Lond B Biol Sci. 2013 Nov 11;368(1632):20130027. doi: 10.1098/rstb.2013.0027. Print 2013 Dec 19.


Positive selection of co-opted mobile genetic elements in a mammalian gene: If you can't beat them, join them.

Franchini LF, de Souza FS, Low MJ, Rubinstein M.

Mob Genet Elements. 2012 Mar 1;2(2):106-109.


Female Mice Lacking Estrogen Receptor-α in Hypothalamic Proopiomelanocortin (POMC) Neurons Display Enhanced Estrogenic Response on Cortical Bone Mass.

Farman HH, Windahl SH, Westberg L, Isaksson H, Egecioglu E, Schele E, Ryberg H, Jansson JO, Tuukkanen J, Koskela A, Xie SK, Hahner L, Zehr J, Clegg DJ, Lagerquist MK, Ohlsson C.

Endocrinology. 2016 Aug;157(8):3242-52. doi: 10.1210/en.2016-1181. Epub 2016 Jun 2.


A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.

Langlais D, Couture C, Sylvain-Drolet G, Drouin J.

Mol Endocrinol. 2011 Feb;25(2):348-59. doi: 10.1210/me.2010-0422. Epub 2010 Dec 30.


The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis.

Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ.

Physiol Behav. 2010 May 11;100(2):165-72. doi: 10.1016/j.physbeh.2010.02.018. Epub 2010 Mar 1.


Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype.

Meister B, Gömüç B, Suarez E, Ishii Y, Dürr K, Gillberg L.

Eur J Neurosci. 2006 Nov;24(10):2731-40.


Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice.

Smart JL, Tolle V, Otero-Corchon V, Low MJ.

Endocrinology. 2007 Feb;148(2):647-59. Epub 2006 Nov 9.


Cellular insulin resistance disrupts hypothalamic mHypoA-POMC/GFP neuronal signaling pathways.

Nazarians-Armavil A, Chalmers JA, Lee CB, Ye W, Belsham DD.

J Endocrinol. 2013 Nov 28;220(1):13-24. doi: 10.1530/JOE-13-0334. Print 2014 Jan.


Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females.

Qiu J, Xue C, Bosch MA, Murphy JG, Fan W, Rønnekleiv OK, Kelly MJ.

Mol Pharmacol. 2007 Oct;72(4):885-96. Epub 2007 Jul 10.


Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence.

Bumaschny VF, de Souza FS, López Leal RA, Santangelo AM, Baetscher M, Levi DH, Low MJ, Rubinstein M.

Mol Endocrinol. 2007 Nov;21(11):2738-49. Epub 2007 Aug 14.


Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.

Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D.

PLoS Biol. 2011 Jul;9(7):e1001112. doi: 10.1371/journal.pbio.1001112. Epub 2011 Jul 26. Erratum in: PLoS Biol. 2016 Mar;14(3):e1002428.


Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons.

Guillod-Maximin E, Roy AF, Vacher CM, Aubourg A, Bailleux V, Lorsignol A, Pénicaud L, Parquet M, Taouis M.

J Endocrinol. 2009 Jan;200(1):93-105. doi: 10.1677/JOE-08-0348. Epub 2008 Oct 29.

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