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Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination.

Wang Y, Guan S, Acharya P, Koop DR, Liu Y, Liao M, Burlingame AL, Correia MA.

J Biol Chem. 2011 Mar 18;286(11):9443-56. doi: 10.1074/jbc.M110.176685. Epub 2011 Jan 5.


Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction.

Wang Y, Guan S, Acharya P, Liu Y, Thirumaran RK, Brandman R, Schuetz EG, Burlingame AL, Correia MA.

Mol Cell Proteomics. 2012 Feb;11(2):M111.010132. doi: 10.1074/mcp.M111.010132. Epub 2011 Nov 17.


Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes.

Wang Y, Kim SM, Trnka MJ, Liu Y, Burlingame AL, Correia MA.

J Biol Chem. 2015 Feb 6;290(6):3308-32. doi: 10.1074/jbc.M114.611525. Epub 2014 Dec 1.


Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.

Kim SM, Wang Y, Nabavi N, Liu Y, Correia MA.

Drug Metab Rev. 2016 Aug;48(3):405-33. doi: 10.1080/03602532.2016.1195403. Epub 2016 Jun 20. Review.


A role for protein phosphorylation in cytochrome P450 3A4 ubiquitin-dependent proteasomal degradation.

Wang Y, Liao M, Hoe N, Acharya P, Deng C, Krutchinsky AN, Correia MA.

J Biol Chem. 2009 Feb 27;284(9):5671-84. doi: 10.1074/jbc.M806104200. Epub 2008 Dec 18.


Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition?

Correia MA, Wang Y, Kim SM, Guan S.

IUBMB Life. 2014 Feb;66(2):78-88. doi: 10.1002/iub.1247. Epub 2014 Feb 3. Review.


CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

Pabarcus MK, Hoe N, Sadeghi S, Patterson C, Wiertz E, Correia MA.

Arch Biochem Biophys. 2009 Mar 1;483(1):66-74. doi: 10.1016/ Epub 2008 Dec 10.


Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells.

Huan JY, Streicher JM, Bleyle LA, Koop DR.

Toxicol Appl Pharmacol. 2004 Sep 15;199(3):332-43.


Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum.

Shmueli A, Tsai YC, Yang M, Braun MA, Weissman AM.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):758-62. doi: 10.1016/j.bbrc.2009.10.045. Epub 2009 Oct 14.


Vacuolar degradation of rat liver CYP2B1 in Saccharomyces cerevisiae: further validation of the yeast model and structural implications for the degradation of mammalian endoplasmic reticulum P450 proteins.

Liao M, Zgoda VG, Murray BP, Correia MA.

Mol Pharmacol. 2005 May;67(5):1460-9. Epub 2005 Feb 9. Erratum in: Mol Pharmacol. 2005 Jun;67(6):2186. Zgoda, Victor A [corrected to Zgoda, Victor G].


Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.

Morishima Y, Peng HM, Lin HL, Hollenberg PF, Sunahara RK, Osawa Y, Pratt WB.

Biochemistry. 2005 Dec 13;44(49):16333-40.


Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?

Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA.

Biochemistry. 2007 Jul 3;46(26):7793-803. Epub 2007 Jun 6.


Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway.

Fisher EA, Khanna NA, McLeod RS.

J Lipid Res. 2011 Jun;52(6):1170-80. doi: 10.1194/jlr.M011726. Epub 2011 Mar 18.


Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation.

Ballar P, Zhong Y, Nagahama M, Tagaya M, Shen Y, Fang S.

J Biol Chem. 2007 Nov 23;282(47):33908-14. Epub 2007 Sep 14.


The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.

Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14422-7. Epub 2001 Nov 27.


A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.

Li W, Tu D, Brunger AT, Ye Y.

Nature. 2007 Mar 15;446(7133):333-7. Epub 2007 Feb 18.


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