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Items: 1 to 20 of 50

1.

The p53 pathway as a target in cancer therapeutics: obstacles and promise.

Mandinova A, Lee SW.

Sci Transl Med. 2011 Jan 5;3(64):64rv1. doi: 10.1126/scitranslmed.3001366. Review.

2.

Small molecule compounds targeting the p53 pathway: are we finally making progress?

Yu X, Narayanan S, Vazquez A, Carpizo DR.

Apoptosis. 2014 Jul;19(7):1055-68. doi: 10.1007/s10495-014-0990-3. Review.

3.

P53: an ubiquitous target of anticancer drugs.

Blagosklonny MV.

Int J Cancer. 2002 Mar 10;98(2):161-6. Review.

4.

Pharmacological reactivation of p53 as a strategy to treat cancer.

Zawacka-Pankau J, Selivanova G.

J Intern Med. 2015 Feb;277(2):248-59. doi: 10.1111/joim.12336. Review.

5.

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient.

Wiman KG.

Oncogene. 2010 Jul 29;29(30):4245-52. doi: 10.1038/onc.2010.188. Epub 2010 May 24. Review.

PMID:
20498645
6.

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Peltonen K, Colis L, Liu H, Jäämaa S, Moore HM, Enbäck J, Laakkonen P, Vaahtokari A, Jones RJ, af Hällström TM, Laiho M.

PLoS One. 2010 Sep 27;5(9):e12996. doi: 10.1371/journal.pone.0012996.

7.

Drugging the p53 pathway: understanding the route to clinical efficacy.

Khoo KH, Verma CS, Lane DP.

Nat Rev Drug Discov. 2014 Mar;13(3):217-36. doi: 10.1038/nrd4236. Review. Erratum in: Nat Rev Drug Discov. 2014 Apr;13(4):314. Hoe, Khoo Kian [corrected to Khoo, Kian Hoe].

PMID:
24577402
8.

Current strategies to target p53 in cancer.

Chen F, Wang W, El-Deiry WS.

Biochem Pharmacol. 2010 Sep 1;80(5):724-30. doi: 10.1016/j.bcp.2010.04.031. Epub 2010 May 5. Review.

PMID:
20450892
9.

Non-genotoxic p53-activators and their significance as antitumor therapy of future.

Nayak SK, Panesar PS, Kumar H.

Curr Med Chem. 2011;18(7):1038-49. Review.

PMID:
21254973
10.

Targeting the p53 pathway.

Golubovskaya VM, Cance WG.

Surg Oncol Clin N Am. 2013 Oct;22(4):747-64. doi: 10.1016/j.soc.2013.06.003. Epub 2013 Jul 30. Review.

11.

The discovery of nongenotoxic activators of p53: building on a cell-based high-throughput screen.

McCarthy AR, Hollick JJ, Westwood NJ.

Semin Cancer Biol. 2010 Feb;20(1):40-5. doi: 10.1016/j.semcancer.2010.02.007. Epub 2010 Mar 4. Review.

PMID:
20206696
12.

Mutant p53 rescue and modulation of p53 redox state.

Bykov VJ, Lambert JM, Hainaut P, Wiman KG.

Cell Cycle. 2009 Aug 15;8(16):2509-17. Epub 2009 Aug 29. Review.

PMID:
19633417
13.

Targeting the p53 family for cancer therapy: 'big brother' joins the fight.

Bell HS, Ryan KM.

Cell Cycle. 2007 Aug 15;6(16):1995-2000. Epub 2007 Jun 19. Review.

PMID:
17721076
14.

The p53 pathway: targets for the development of novel cancer therapeutics.

Wang S, El-Deiry WS.

Cancer Treat Res. 2004;119:175-87. Review. No abstract available.

PMID:
15164878
15.

Mutant p53 reactivation by small molecules makes its way to the clinic.

Bykov VJ, Wiman KG.

FEBS Lett. 2014 Aug 19;588(16):2622-7. doi: 10.1016/j.febslet.2014.04.017. Epub 2014 Apr 24. Review.

16.

[p53-regulating pathways as targets for personalized cancer therapy].

Höpker K, Reinhardt HC.

Dtsch Med Wochenschr. 2013 Jan;138(3):82-6. doi: 10.1055/s-0032-1327380. Epub 2013 Jan 8. Review. German.

PMID:
23299342
17.

Targeting p53 by small molecules in hematological malignancies.

Saha MN, Qiu L, Chang H.

J Hematol Oncol. 2013 Mar 27;6:23. doi: 10.1186/1756-8722-6-23. Review.

18.

Therapeutic targeting of p53 by small molecules.

Selivanova G.

Semin Cancer Biol. 2010 Feb;20(1):46-56. doi: 10.1016/j.semcancer.2010.02.006. Epub 2010 Mar 3. Review.

PMID:
20206268
19.

Modulating the p53 pathway.

Dey A, Lane DP, Verma CS.

Semin Cancer Biol. 2010 Feb;20(1):3-9. doi: 10.1016/j.semcancer.2010.02.004. Epub 2010 Mar 1. Review.

PMID:
20193765
20.

Improving cancer therapy through p53 management.

Haupt S, Haupt Y.

Cell Cycle. 2004 Jul;3(7):912-6. Epub 2004 Jul 2. Review.

PMID:
15254405

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