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Items: 1 to 20 of 271

1.

Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells.

Hatanaka M, Tanabe K, Yanai A, Ohta Y, Kondo M, Akiyama M, Shinoda K, Oka Y, Tanizawa Y.

Hum Mol Genet. 2011 Apr 1;20(7):1274-84. doi: 10.1093/hmg/ddq568. Epub 2011 Jan 3.

PMID:
21199859
2.

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.

PMID:
16215705
3.

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.

Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, Aburatani H, Miyazaki J, Oka Y.

Hum Mol Genet. 2006 May 15;15(10):1600-9. Epub 2006 Mar 28.

PMID:
16571599
4.
5.

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion.

Ishihara H, Takeda S, Tamura A, Takahashi R, Yamaguchi S, Takei D, Yamada T, Inoue H, Soga H, Katagiri H, Tanizawa Y, Oka Y.

Hum Mol Genet. 2004 Jun 1;13(11):1159-70. Epub 2004 Mar 31.

PMID:
15056606
6.

Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.

Gharanei S, Zatyka M, Astuti D, Fenton J, Sik A, Nagy Z, Barrett TG.

Hum Mol Genet. 2013 Jan 15;22(2):203-17. doi: 10.1093/hmg/dds400. Epub 2012 Oct 3.

PMID:
23035048
7.

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.

Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y.

Diabetologia. 2009 Apr;52(4):653-63. doi: 10.1007/s00125-009-1270-6. Epub 2009 Feb 4.

PMID:
19190890
8.

[Positional cloning of the gene(WFS1) for Wolfram syndrome].

Tanizawa Y, Inoue H, Oka Y.

Rinsho Byori. 2000 Oct;48(10):941-7. Japanese.

PMID:
11215108
9.

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain.

Takeda K, Inoue H, Tanizawa Y, Matsuzaki Y, Oba J, Watanabe Y, Shinoda K, Oka Y.

Hum Mol Genet. 2001 Mar 1;10(5):477-84.

PMID:
11181571
10.

[Wolfram syndrome: clinical features, molecular genetics of WFS1 gene].

Tanabe K, Matsunaga K, Hatanaka M, Akiyama M, Tanizawa Y.

Nihon Rinsho. 2015 Feb;73(2):341-9. Review. Japanese.

PMID:
25764693
11.

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.

Fonseca SG, Ishigaki S, Oslowski CM, Lu S, Lipson KL, Ghosh R, Hayashi E, Ishihara H, Oka Y, Permutt MA, Urano F.

J Clin Invest. 2010 Mar;120(3):744-55. doi: 10.1172/JCI39678. Epub 2010 Feb 15.

12.

RNA-sequencing of WFS1-deficient pancreatic islets.

Ivask M, Hugill A, Kõks S.

Physiol Rep. 2016 Apr;4(7). pii: e12750. doi: 10.14814/phy2.12750.

13.

Wolfram syndrome 1 and Wolfram syndrome 2.

Rigoli L, Di Bella C.

Curr Opin Pediatr. 2012 Aug;24(4):512-7. doi: 10.1097/MOP.0b013e328354ccdf. Review.

PMID:
22790102
14.

Ectopic expression of syncollin in INS-1 beta-cells sorts it into granules and impairs regulated secretion.

Li J, Luo R, Hooi SC, Ruga P, Zhang J, Meda P, Li G.

Biochemistry. 2005 Mar 22;44(11):4365-74.

PMID:
15766266
15.

[Genetic diagnosis of diabetes mellitus: Wolfram syndrome--from positional cloning to DNA diagnosis].

Tanizawa Y.

Rinsho Byori. 2003 Jun;51(6):544-9. Review. Japanese.

PMID:
12884741
16.

Wolfram syndrome and WFS1 gene.

Rigoli L, Lombardo F, Di Bella C.

Clin Genet. 2011 Feb;79(2):103-17. doi: 10.1111/j.1399-0004.2010.01522.x. Epub 2010 Aug 26. Review.

PMID:
20738327
17.

Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product.

Hofmann S, Philbrook C, Gerbitz KD, Bauer MF.

Hum Mol Genet. 2003 Aug 15;12(16):2003-12.

PMID:
12913071
18.

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.

Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y.

Cell Metab. 2008 Mar;7(3):269-76. doi: 10.1016/j.cmet.2008.01.008.

19.

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum.

Takei D, Ishihara H, Yamaguchi S, Yamada T, Tamura A, Katagiri H, Maruyama Y, Oka Y.

FEBS Lett. 2006 Oct 16;580(24):5635-40. Epub 2006 Sep 15.

20.

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.

Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Oka Y, Urano F.

J Biol Chem. 2005 Nov 25;280(47):39609-15. Epub 2005 Sep 29.

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