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Items: 1 to 20 of 83

1.

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit.

Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM.

Mol Neurodegener. 2010 Dec 23;5:61. doi: 10.1186/1750-1326-5-61.

2.

Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease.

Corbett BF, Leiser SC, Ling HP, Nagy R, Breysse N, Zhang X, Hazra A, Brown JT, Randall AD, Wood A, Pangalos MN, Reinhart PH, Chin J.

J Neurosci. 2013 Apr 17;33(16):7020-6. doi: 10.1523/JNEUROSCI.2325-12.2013. Erratum in: J Neurosci. 2013 Jun 26;33(26):10934. Brown, Jon T [added]; Randall, Andrew D [added].

3.

The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells.

Kim DY, Wertz MH, Gautam V, D'Avanzo C, Bhattacharyya R, Kovacs DM.

Neurodegener Dis. 2014;13(2-3):64-68. doi: 10.1159/000354669. Epub 2013 Nov 5.

4.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

PMID:
23773065
5.

BACE1 regulates voltage-gated sodium channels and neuronal activity.

Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM.

Nat Cell Biol. 2007 Jul;9(7):755-64. Epub 2007 Jun 18.

6.

Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.

Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM.

J Biol Chem. 2005 Jun 17;280(24):23251-61. Epub 2005 Apr 14. Erratum in: J Biol Chem. 2005 Aug 19;280(33):29988.

7.

Reduced sodium channel Na(v)1.1 levels in BACE1-null mice.

Kim DY, Gersbacher MT, Inquimbert P, Kovacs DM.

J Biol Chem. 2011 Mar 11;286(10):8106-16. doi: 10.1074/jbc.M110.134692. Epub 2010 Dec 29.

8.

Non-proteolytic effect of beta-site APP-cleaving enzyme 1 (BACE1) on sodium channel function.

Huth T, Schmidt-Neuenfeldt K, Rittger A, Saftig P, Reiss K, Alzheimer C.

Neurobiol Dis. 2009 Feb;33(2):282-9. doi: 10.1016/j.nbd.2008.10.015. Epub 2008 Nov 8.

PMID:
19056495
9.
10.

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.

Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13554-9. Epub 2001 Nov 6.

11.

Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.

J Alzheimers Dis. 2005 Apr;7(2):139-48; discussion 173-80.

PMID:
15851852
12.

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.

Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N.

J Biol Chem. 2005 Jun 17;280(24):23009-17. Epub 2005 Apr 11.

13.

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase.

Scholefield Z, Yates EA, Wayne G, Amour A, McDowell W, Turnbull JE.

J Cell Biol. 2003 Oct 13;163(1):97-107. Epub 2003 Oct 6.

14.

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G.

J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3.

15.

MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.

Sun LH, Yan ML, Hu XL, Peng LW, Che H, Bao YN, Guo F, Liu T, Chen X, Zhang R, Ban T, Wang N, Liu HL, Hou X, Ai J.

Mol Neurodegener. 2015 Aug 11;10:36. doi: 10.1186/s13024-015-0032-9.

16.

Employing a superior BACE1 cleavage sequence to probe cellular APP processing.

Tomasselli AG, Qahwash I, Emmons TL, Lu Y, Leone JW, Lull JM, Fok KF, Bannow CA, Smith CW, Bienkowski MJ, Heinrikson RL, Yan R.

J Neurochem. 2003 Mar;84(5):1006-17.

17.

The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.

Zhao J, O'Connor T, Vassar R.

J Neuroinflammation. 2011 Nov 2;8:150. doi: 10.1186/1742-2094-8-150.

18.

Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.

Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC.

J Neurochem. 2004 Dec;91(6):1249-59.

19.

Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.

Volbracht C, Penzkofer S, Mansson D, Christensen KV, Fog K, Schildknecht S, Leist M, Nielsen J.

Anal Biochem. 2009 Apr 15;387(2):208-20. doi: 10.1016/j.ab.2009.01.008. Epub 2009 Jan 15.

PMID:
19454261
20.

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