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Items: 1 to 20 of 103


Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice.

Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, Hassenpflug J, Freitag-Wolf S, Varoga D, Lippross S, Pufe T.

Ann Rheum Dis. 2011 May;70(5):844-50. doi: 10.1136/ard.2010.132720. Epub 2010 Dec 20.


Allylpyrocatechol Attenuates Collagen-Induced Arthritis via Attenuation of Oxidative Stress Secondary to Modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 Pathways.

De S, Manna A, Kundu S, De Sarkar S, Chatterjee U, Sen T, Chattopadhyay S, Chatterjee M.

J Pharmacol Exp Ther. 2017 Feb;360(2):249-259. doi: 10.1124/jpet.116.238444. Epub 2016 Nov 17.


Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease.

Maicas N, Ferrándiz ML, Brines R, Ibáñez L, Cuadrado A, Koenders MI, van den Berg WB, Alcaraz MJ.

Antioxid Redox Signal. 2011 Aug 15;15(4):889-901. doi: 10.1089/ars.2010.3835. Epub 2011 May 25.


Protective effects of nuclear factor erythroid 2-related factor 2 on whole body heat stress-induced oxidative damage in the mouse testis.

Li Y, Huang Y, Piao Y, Nagaoka K, Watanabe G, Taya K, Li C.

Reprod Biol Endocrinol. 2013 Mar 21;11:23. doi: 10.1186/1477-7827-11-23.


Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response.

Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.

Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1553-61. doi: 10.1161/ATVBAHA.110.204123. Epub 2010 May 6.


Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis.

Mould AW, Tonks ID, Cahill MM, Pettit AR, Thomas R, Hayward NK, Kay GF.

Arthritis Rheum. 2003 Sep;48(9):2660-9.


The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.

Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb-Pap A, Joosten LA, van den Berg WB, Kollias G, Eckes B, Pap T.

Arthritis Rheum. 2012 May;64(5):1359-68. doi: 10.1002/art.33487.


Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis.

Pakozdi A, Amin MA, Haas CS, Martinez RJ, Haines GK 3rd, Santos LL, Morand EF, David JR, Koch AE.

Arthritis Res Ther. 2006;8(4):R132.


Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

Makabe S, Takahashi Y, Watanabe H, Murakami M, Ohba T, Ito H.

Atherosclerosis. 2010 Dec;213(2):377-84. doi: 10.1016/j.atherosclerosis.2010.07.059. Epub 2010 Aug 19.


Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.

van Lent PL, Hofkens W, Blom AB, Grevers L, Sloetjes A, Takahashi N, van Tits LJ, Vogl T, Roth J, de Winther MP, van den Berg WB.

Arthritis Rheum. 2009 Oct;60(10):2954-65. doi: 10.1002/art.24908.


Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis.

Cai D, Yin S, Yang J, Jiang Q, Cao W.

Arthritis Res Ther. 2015 Sep 26;17:269. doi: 10.1186/s13075-015-0774-3.


Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction.

Park SY, Lee SW, Shin HK, Chung WT, Lee WS, Rhim BY, Hong KW, Kim CD.

Arthritis Rheum. 2010 Mar;62(3):732-41. doi: 10.1002/art.27291.


The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.

Engdahl C, Börjesson AE, Forsman HF, Andersson A, Stubelius A, Krust A, Chambon P, Islander U, Ohlsson C, Carlsten H, Lagerquist MK.

Arthritis Res Ther. 2014 Jul 15;16(4):R150. doi: 10.1186/ar4612.


A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase.

Park SH, Jang JH, Chen CY, Na HK, Surh YJ.

Toxicology. 2010 Nov 28;278(1):131-9. doi: 10.1016/j.tox.2010.04.003. Epub 2010 Apr 22.


Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.

van Lent PL, Grevers L, Lubberts E, de Vries TJ, Nabbe KC, Verbeek S, Oppers B, Sloetjes A, Blom AB, van den Berg WB.

Arthritis Rheum. 2006 Dec;54(12):3868-77.


Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency.

Lu Y, Gong P, Cederbaum AI.

Toxicology. 2008 Oct 30;252(1-3):9-16. doi: 10.1016/j.tox.2008.07.058. Epub 2008 Aug 3.


Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint.

Lippross S, Moeller B, Haas H, Tohidnezhad M, Steubesand N, Wruck CJ, Kurz B, Seekamp A, Pufe T, Varoga D.

Arthritis Rheum. 2011 Nov;63(11):3344-53. doi: 10.1002/art.30547.


Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2.

Dreger H, Westphal K, Wilck N, Baumann G, Stangl V, Stangl K, Meiners S.

Cardiovasc Res. 2010 Jan 15;85(2):395-403. doi: 10.1093/cvr/cvp279. Epub 2009 Aug 13.


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