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GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway.

Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S.

Mol Cancer Res. 2011 Feb;9(2):195-202. doi: 10.1158/1541-7786.MCR-10-0363. Epub 2010 Dec 14.


Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.

Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S.

BMC Cancer. 2012 Nov 30;12:564. doi: 10.1186/1471-2407-12-564.


The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.

Noratto GD, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott SU.

Mol Nutr Food Res. 2013 Sep;57(9):1638-48. doi: 10.1002/mnfr.201200609. Epub 2013 Mar 8.


The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.

Sreevalsan S, Safe S.

Mol Cancer Ther. 2013 Nov;12(11):2483-93. doi: 10.1158/1535-7163.MCT-13-0486. Epub 2013 Sep 12.


Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10.

Mertens-Talcott SU, Noratto GD, Li X, Angel-Morales G, Bertoldi MC, Safe S.

Mol Carcinog. 2013 Aug;52(8):591-602. doi: 10.1002/mc.21893. Epub 2012 Mar 7.


Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a.

Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S.

Mol Pharmacol. 2010 Aug;78(2):226-36. doi: 10.1124/mol.110.064451. Epub 2010 May 20. Erratum in: Mol Pharmacol. 2011 Feb;79(2):336.


Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.

Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, Chadalapaka G, Wu F, Mertens-Talcott S, Vanderlaag K, Cho SD, Smith R 3rd, Safe S.

Int J Cancer. 2009 Oct 15;125(8):1965-74. doi: 10.1002/ijc.24530.


Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors.

Li X, Pathi SS, Safe S.

BMC Cancer. 2015 Dec 16;15:974. doi: 10.1186/s12885-015-1956-8.


Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a.

Del Follo-Martinez A, Banerjee N, Li X, Safe S, Mertens-Talcott S.

Nutr Cancer. 2013;65(3):494-504. doi: 10.1080/01635581.2012.725194.


Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a.

Li W, Liu M, Xu YF, Feng Y, Che JP, Wang GC, Zheng JH.

Oncol Rep. 2014 Jan;31(1):117-24. doi: 10.3892/or.2013.2811. Epub 2013 Oct 24.


Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.

Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S.

Mol Cancer Ther. 2012 Jul;11(7):1421-31. doi: 10.1158/1535-7163.MCT-12-0026. Epub 2012 May 2.


Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.

Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S.

Nutr Cancer. 2011;63(7):1133-42. doi: 10.1080/01635581.2011.605984. Epub 2011 Sep 15.


Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors.

Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S.

Carcinogenesis. 2013 Dec;34(12):2870-9. doi: 10.1093/carcin/bgt231. Epub 2013 Jun 26.


Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors.

Pathi S, Li X, Safe S.

Mol Carcinog. 2014 Feb;53 Suppl 1:E53-61. doi: 10.1002/mc.22010. Epub 2013 May 14.


Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents.

Jutooru I, Guthrie AS, Chadalapaka G, Pathi S, Kim K, Burghardt R, Jin UH, Safe S.

Mol Cell Biol. 2014 Jul;34(13):2382-95. doi: 10.1128/MCB.01602-13. Epub 2014 Apr 14.


Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth.

Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S.

Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.


Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.

Jutooru I, Chadalapaka G, Lei P, Safe S.

J Biol Chem. 2010 Aug 13;285(33):25332-44. doi: 10.1074/jbc.M109.095240. Epub 2010 Jun 9.


Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation.

Banerjee N, Talcott S, Safe S, Mertens-Talcott SU.

Breast Cancer Res Treat. 2012 Nov;136(1):21-34. doi: 10.1007/s10549-012-2224-0. Epub 2012 Sep 2.

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