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Identification of new functional regions in hepatitis C virus envelope glycoprotein E2.

Albecka A, Montserret R, Krey T, Tarr AW, Diesis E, Ball JK, Descamps V, Duverlie G, Rey F, Penin F, Dubuisson J.

J Virol. 2011 Feb;85(4):1777-92. doi: 10.1128/JVI.02170-10. Epub 2010 Dec 8.


Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.

Falson P, Bartosch B, Alsaleh K, Tews BA, Loquet A, Ciczora Y, Riva L, Montigny C, Montpellier C, Duverlie G, Pécheur EI, le Maire M, Cosset FL, Dubuisson J, Penin F.

J Virol. 2015 Oct;89(20):10333-46. doi: 10.1128/JVI.00991-15. Epub 2015 Aug 5.


Identification of conserved residues in hepatitis C virus envelope glycoprotein E2 that modulate virus dependence on CD81 and SRB1 entry factors.

Lavie M, Sarrazin S, Montserret R, Descamps V, Baumert TF, Duverlie G, Séron K, Penin F, Dubuisson J.

J Virol. 2014 Sep;88(18):10584-97. doi: 10.1128/JVI.01402-14. Epub 2014 Jul 2.


The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity.

McCaffrey K, Gouklani H, Boo I, Poumbourios P, Drummer HE.

J Gen Virol. 2011 Jan;92(Pt 1):112-21. doi: 10.1099/vir.0.026385-0. Epub 2010 Oct 6.


Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry.

Douam F, Dao Thi VL, Maurin G, Fresquet J, Mompelat D, Zeisel MB, Baumert TF, Cosset FL, Lavillette D.

Hepatology. 2014 Mar;59(3):776-88. doi: 10.1002/hep.26733. Epub 2014 Jan 28.


Dissecting the role of putative CD81 binding regions of E2 in mediating HCV entry: putative CD81 binding region 1 is not involved in CD81 binding.

Rothwangl KB, Manicassamy B, Uprichard SL, Rong L.

Virol J. 2008 Mar 20;5:46. doi: 10.1186/1743-422X-5-46.


Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus.

Lavillette D, Pécheur EI, Donot P, Fresquet J, Molle J, Corbau R, Dreux M, Penin F, Cosset FL.

J Virol. 2007 Aug;81(16):8752-65. Epub 2007 May 30.


Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry.

Carlsen TH, Scheel TK, Ramirez S, Foung SK, Bukh J.

J Virol. 2013 Feb;87(3):1385-99. doi: 10.1128/JVI.00684-12. Epub 2012 Nov 14.


HCV envelope protein function is dependent on the peptides preceding the glycoproteins.

Bian T, Zhou Y, Bi S, Tan W, Wang Y.

Biochem Biophys Res Commun. 2009 Jan 2;378(1):118-22. doi: 10.1016/j.bbrc.2008.11.024. Epub 2008 Nov 20.


Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles.

Russell RS, Kawaguchi K, Meunier JC, Takikawa S, Faulk K, Bukh J, Purcell RH, Emerson SU.

J Viral Hepat. 2009 Sep;16(9):621-32. doi: 10.1111/j.1365-2893.2009.01111.x. Epub 2009 Mar 11.


Analysis of a conserved RGE/RGD motif in HCV E2 in mediating entry.

Rothwangl KB, Rong L.

Virol J. 2009 Jan 26;6:12. doi: 10.1186/1743-422X-6-12.


Identification of interactions in the E1E2 heterodimer of hepatitis C virus important for cell entry.

Maurin G, Fresquet J, Granio O, Wychowski C, Cosset FL, Lavillette D.

J Biol Chem. 2011 Jul 8;286(27):23865-76. doi: 10.1074/jbc.M110.213942. Epub 2011 May 9.


Hepatitis C virus envelope glycoproteins complementation patterns and the role of the ecto- and transmembrane domains.

Lin X, Zhang Y, Bi S, Lu J, Zhao H, Tan W, Li D, Wang Y.

Biochem Biophys Res Commun. 2009 Jul 24;385(2):257-62. doi: 10.1016/j.bbrc.2009.05.068. Epub 2009 May 21.


Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region.

Alhammad Y, Gu J, Boo I, Harrison D, McCaffrey K, Vietheer PT, Edwards S, Quinn C, Coulibaly F, Poumbourios P, Drummer HE.

J Virol. 2015 Dec;89(24):12245-61. doi: 10.1128/JVI.02070-15. Epub 2015 Sep 16.


Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 contain reduced cysteine residues essential for virus entry.

Fraser J, Boo I, Poumbourios P, Drummer HE.

J Biol Chem. 2011 Sep 16;286(37):31984-92. doi: 10.1074/jbc.M111.269605. Epub 2011 Jul 15.


Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

Keck ZY, Xia J, Wang Y, Wang W, Krey T, Prentoe J, Carlsen T, Li AY, Patel AH, Lemon SM, Bukh J, Rey FA, Foung SK.

PLoS Pathog. 2012;8(4):e1002653. doi: 10.1371/journal.ppat.1002653. Epub 2012 Apr 12.


Architecture of the hepatitis C virus E1 glycoprotein transmembrane domain studied by NMR.

Zazrin H, Shaked H, Chill JH.

Biochim Biophys Acta. 2014 Mar;1838(3):784-92. doi: 10.1016/j.bbamem.2013.10.021. Epub 2013 Nov 2.

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