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Items: 1 to 20 of 133


A tincture of hepcidin cures all: the potential for hepcidin therapeutics.

Bartnikas TB, Fleming MD.

J Clin Invest. 2010 Dec;120(12):4187-90. doi: 10.1172/JCI45043. Epub 2010 Nov 22.


Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.

Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, Guy E, Muirhead K, Rao N, Roy CN, Andrews NC, Nemeth E, Follenzi A, An X, Mohandas N, Ginzburg Y, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S.

J Clin Invest. 2010 Dec;120(12):4466-77. doi: 10.1172/JCI41717. Epub 2010 Nov 22.


Hepcidin in beta-thalassemia.

Nemeth E.

Ann N Y Acad Sci. 2010 Aug;1202:31-5. doi: 10.1111/j.1749-6632.2010.05585.x.


Liver iron concentrations and urinary hepcidin in beta-thalassemia.

Origa R, Galanello R, Ganz T, Giagu N, Maccioni L, Faa G, Nemeth E.

Haematologica. 2007 May;92(5):583-8.


[Thalassemia: therapeutic hopes carried by hepcidin].

Vaulont S, Labie D.

Med Sci (Paris). 2011 May;27(5):473-5. doi: 10.1051/medsci/2011275009. Epub 2011 May 25. French. No abstract available.


An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

Schmidt PJ, Toudjarska I, Sendamarai AK, Racie T, Milstein S, Bettencourt BR, Hettinger J, Bumcrot D, Fleming MD.

Blood. 2013 Feb 14;121(7):1200-8. doi: 10.1182/blood-2012-09-453977. Epub 2012 Dec 6.


Hepcidin and Hfe in iron overload in beta-thalassemia.

Gardenghi S, Ramos P, Follenzi A, Rao N, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S.

Ann N Y Acad Sci. 2010 Aug;1202:221-5. doi: 10.1111/j.1749-6632.2010.05595.x. Review.


mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models.

Weizer-Stern O, Adamsky K, Amariglio N, Rachmilewitz E, Breda L, Rivella S, Rechavi G.

Am J Hematol. 2006 Jul;81(7):479-83.


Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia.

Gardenghi S, Grady RW, Rivella S.

Hematol Oncol Clin North Am. 2010 Dec;24(6):1089-107. doi: 10.1016/j.hoc.2010.08.003. Epub 2010 Oct 15. Review.


Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models.

Ramos P, Melchiori L, Gardenghi S, Van-Roijen N, Grady RW, Ginzburg Y, Rivella S.

Ann N Y Acad Sci. 2010 Aug;1202:24-30. doi: 10.1111/j.1749-6632.2010.05596.x.


Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.

Schmidt PJ, Fleming MD.

Hematol Oncol Clin North Am. 2014 Apr;28(2):387-401. doi: 10.1016/j.hoc.2013.11.004. Epub 2014 Jan 18. Review.


Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia.

De Franceschi L, Daraio F, Filippini A, Carturan S, Muchitsch EM, Roetto A, Camaschella C.

Haematologica. 2006 Oct;91(10):1336-42.


Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice.

Bartnikas TB, Andrews NC, Fleming MD.

Blood. 2011 Jan 13;117(2):630-7. doi: 10.1182/blood-2010-05-287359. Epub 2010 Oct 18.


Urinary hepcidin in congenital chronic anemias.

Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, Cunningham MJ.

Pediatr Blood Cancer. 2007 Jan;48(1):57-63.


Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with β-thalassemia major: a longitudinal study.

Pasricha SR, Frazer DM, Bowden DK, Anderson GJ.

Blood. 2013 Jul 4;122(1):124-33. doi: 10.1182/blood-2012-12-471441. Epub 2013 May 8.


Hepcidin levels and iron status in beta-thalassemia major patients with hepatitis C virus infection.

Hendy OM, Allam M, Allam A, Attia MH, El Taher S, Eldin MM, Ali A.

Egypt J Immunol. 2010;17(2):33-44.


Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.

Kautz L, Jung G, Du X, Gabayan V, Chapman J, Nasoff M, Nemeth E, Ganz T.

Blood. 2015 Oct 22;126(17):2031-7. doi: 10.1182/blood-2015-07-658419. Epub 2015 Aug 14.


Hepcidin and iron-loading anemias.

Nemeth E, Ganz T.

Haematologica. 2006 Jun;91(6):727-32. No abstract available.


β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism.

Ginzburg Y, Rivella S.

Blood. 2011 Oct 20;118(16):4321-30. doi: 10.1182/blood-2011-03-283614. Epub 2011 Jul 18. Review.


The molecular basis of iron overload disorders and iron-linked anemias.

Kaplan J, Ward DM, De Domenico I.

Int J Hematol. 2011 Jan;93(1):14-20. doi: 10.1007/s12185-010-0760-0. Epub 2011 Jan 7. Review.


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