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Items: 1 to 20 of 102


Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.

Wendorff AA, Koch U, Wunderlich FT, Wirth S, Dubey C, Brüning JC, MacDonald HR, Radtke F.

Immunity. 2010 Nov 24;33(5):671-84. doi: 10.1016/j.immuni.2010.11.014.


Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.

Kannan S, Fang W, Song G, Mullighan CG, Hammitt R, McMurray J, Zweidler-McKay PA.

Blood. 2011 Mar 10;117(10):2891-900. doi: 10.1182/blood-2009-12-253419. Epub 2011 Jan 11.


E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment.

Ikawa T, Kawamoto H, Goldrath AW, Murre C.

J Exp Med. 2006 May 15;203(5):1329-42. Epub 2006 May 8.


Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

Guiu J, Shimizu R, D'Altri T, Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.

J Exp Med. 2013 Jan 14;210(1):71-84. doi: 10.1084/jem.20120993. Epub 2012 Dec 24.


Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice.

Scheikl T, Reis B, Pfeffer K, Holzmann B, Beer S.

Mol Immunol. 2009 Feb;46(5):969-77. doi: 10.1016/j.molimm.2008.09.023. Epub 2008 Oct 31.


Multiple roles of Notch signaling in the regulation of epidermal development.

Moriyama M, Durham AD, Moriyama H, Hasegawa K, Nishikawa S, Radtke F, Osawa M.

Dev Cell. 2008 Apr;14(4):594-604. doi: 10.1016/j.devcel.2008.01.017.


Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells.

Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y.

Blood. 2011 Jul 21;118(3):586-93. doi: 10.1182/blood-2011-02-334995. Epub 2011 May 23.


Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development.

Kitagawa M, Hojo M, Imayoshi I, Goto M, Ando M, Ohtsuka T, Kageyama R, Miyamoto S.

Mech Dev. 2013 Sep-Oct;130(9-10):458-66. doi: 10.1016/j.mod.2013.07.001. Epub 2013 Jul 17.


Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.

Dudley DD, Wang HC, Sun XH.

PLoS One. 2009 Aug 18;4(8):e6678. doi: 10.1371/journal.pone.0006678.


Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.

Zhu X, Zhang J, Tollkuhn J, Ohsawa R, Bresnick EH, Guillemot F, Kageyama R, Rosenfeld MG.

Genes Dev. 2006 Oct 1;20(19):2739-53.


Ikaros regulates Notch target gene expression in developing thymocytes.

Chari S, Winandy S.

J Immunol. 2008 Nov 1;181(9):6265-74.


Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.

Murata J, Ohtsuka T, Tokunaga A, Nishiike S, Inohara H, Okano H, Kageyama R.

J Neurosci Res. 2009 Dec;87(16):3521-34. doi: 10.1002/jnr.22169.


T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.

De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A.

Nat Immunol. 2013 Dec;14(12):1277-84. doi: 10.1038/ni.2760. Epub 2013 Nov 3.


Oscillations in notch signaling regulate maintenance of neural progenitors.

Shimojo H, Ohtsuka T, Kageyama R.

Neuron. 2008 Apr 10;58(1):52-64. doi: 10.1016/j.neuron.2008.02.014.


Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas.

Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T.

J Clin Invest. 2006 Jun;116(6):1484-93. Epub 2006 May 18.


Notch signaling in Sertoli cells regulates cyclical gene expression of Hes1 but is dispensable for mouse spermatogenesis.

Hasegawa K, Okamura Y, Saga Y.

Mol Cell Biol. 2012 Jan;32(1):206-15. doi: 10.1128/MCB.06063-11. Epub 2011 Oct 28.


Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program.

Weerkamp F, Luis TC, Naber BA, Koster EE, Jeannotte L, van Dongen JJ, Staal FJ.

Leukemia. 2006 Nov;20(11):1967-77. Epub 2006 Sep 21.


Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway.

Lee JH, Suk J, Park J, Kim SB, Kwak SS, Kim JW, Lee CH, Byun B, Ahn JK, Joe CO.

Mol Cancer Res. 2009 Oct;7(10):1663-71. doi: 10.1158/1541-7786.MCR-09-0191. Epub 2009 Oct 6.


ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors.

Sanalkumar R, Indulekha CL, Divya TS, Divya MS, Anto RJ, Vinod B, Vidyanand S, Jagatha B, Venugopal S, James J.

J Neurochem. 2010 May;113(4):807-18. doi: 10.1111/j.1471-4159.2010.06574.x. Epub 2010 Jan 8.


Ikaros represses the transcriptional response to Notch signaling in T-cell development.

Kleinmann E, Geimer Le Lay AS, Sellars M, Kastner P, Chan S.

Mol Cell Biol. 2008 Dec;28(24):7465-75. doi: 10.1128/MCB.00715-08. Epub 2008 Oct 13.

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