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Items: 1 to 20 of 104

1.

Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.

Gómez-del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K.

Immunity. 2010 Nov 24;33(5):685-98. doi: 10.1016/j.immuni.2010.11.008.

2.

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.

Blood. 2010 Dec 16;116(25):5443-54. doi: 10.1182/blood-2010-05-286658. Epub 2010 Sep 9.

3.

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.

Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5106-11. doi: 10.1073/pnas.1001064107. Epub 2010 Mar 1.

4.

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.

Sontani Y, Chapman G, Papathanasiou P, Dunwoodie S, Goodnow CC, Hoyne GF.

Leuk Res. 2011 Nov;35(11):1512-9. doi: 10.1016/j.leukres.2011.07.024. Epub 2011 Aug 15.

PMID:
21840596
5.

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.

Dumortier A, Jeannet R, Kirstetter P, Kleinmann E, Sellars M, dos Santos NR, Thibault C, Barths J, Ghysdael J, Punt JA, Kastner P, Chan S.

Mol Cell Biol. 2006 Jan;26(1):209-20.

6.

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC.

Blood. 2010 Dec 16;116(25):5455-64. doi: 10.1182/blood-2010-05-286328. Epub 2010 Sep 17.

7.

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.

Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F.

Oncotarget. 2015 Mar 10;6(7):5102-17.

8.

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.

Witkowski MT, Cimmino L, Hu Y, Trimarchi T, Tagoh H, McKenzie MD, Best SA, Tuohey L, Willson TA, Nutt SL, Busslinger M, Aifantis I, Smyth GK, Dickins RA.

Leukemia. 2015 Jun;29(6):1301-11. doi: 10.1038/leu.2015.27. Epub 2015 Feb 6.

9.

Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.

Kathrein KL, Chari S, Winandy S.

J Biol Chem. 2008 Apr 18;283(16):10476-84. doi: 10.1074/jbc.M709643200. Epub 2008 Feb 20.

10.

Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.

Rakowski LA, Garagiola DD, Li CM, Decker M, Caruso S, Jones M, Kuick R, Cierpicki T, Maillard I, Chiang MY.

Cancer Res. 2013 Jan 15;73(2):930-41. doi: 10.1158/0008-5472.CAN-12-1389. Epub 2012 Nov 16.

11.

SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.

Gerby B, Tremblay CS, Tremblay M, Rojas-Sutterlin S, Herblot S, Hébert J, Sauvageau G, Lemieux S, Lécuyer E, Veiga DF, Hoang T.

PLoS Genet. 2014 Dec 18;10(12):e1004768. doi: 10.1371/journal.pgen.1004768. eCollection 2014 Dec.

12.

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

Yatim A, Benne C, Sobhian B, Laurent-Chabalier S, Deas O, Judde JG, Lelievre JD, Levy Y, Benkirane M.

Mol Cell. 2012 Nov 9;48(3):445-58. doi: 10.1016/j.molcel.2012.08.022. Epub 2012 Sep 27.

13.

Notch dimerization is required for leukemogenesis and T-cell development.

Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS.

Genes Dev. 2010 Nov 1;24(21):2395-407. doi: 10.1101/gad.1975210. Epub 2010 Oct 8.

14.

Ikaros represses the transcriptional response to Notch signaling in T-cell development.

Kleinmann E, Geimer Le Lay AS, Sellars M, Kastner P, Chan S.

Mol Cell Biol. 2008 Dec;28(24):7465-75. doi: 10.1128/MCB.00715-08. Epub 2008 Oct 13.

15.

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.

Berquam-Vrieze KE, Swing DA, Tessarollo L, Dupuy AJ.

Genesis. 2012 Feb;50(2):112-8. doi: 10.1002/dvg.20798. Epub 2012 Jan 6.

16.

Notch1 and IL-7 receptor signalling in early T-cell development and leukaemia.

González-García S, García-Peydró M, Alcain J, Toribio ML.

Curr Top Microbiol Immunol. 2012;360:47-73. doi: 10.1007/82_2012_231. Review.

PMID:
22695916
17.

Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.

Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J.

J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14. Erratum in: J Biol Chem. 2013 Dec 27;288(52):37368.

18.

Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.

Koyama D, Kikuchi J, Hiraoka N, Wada T, Kurosawa H, Chiba S, Furukawa Y.

Leukemia. 2014 Jun;28(6):1216-26. doi: 10.1038/leu.2013.366. Epub 2013 Dec 4.

19.

Epigenetic regulation of the Ink4a-Arf (Cdkn2a) tumor suppressor locus in the initiation and progression of Notch1-driven T cell acute lymphoblastic leukemia.

Volanakis EJ, Boothby MR, Sherr CJ.

Exp Hematol. 2013 Apr;41(4):377-86. doi: 10.1016/j.exphem.2012.11.006. Epub 2012 Nov 23.

20.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Durinck K, Wallaert A, Van de Walle I, Van Loocke W, Volders PJ, Vanhauwaert S, Geerdens E, Benoit Y, Van Roy N, Poppe B, Soulier J, Cools J, Mestdagh P, Vandesompele J, Rondou P, Van Vlierberghe P, Taghon T, Speleman F.

Haematologica. 2014 Dec;99(12):1808-16. doi: 10.3324/haematol.2014.115683. Epub 2014 Oct 24.

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