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Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.

Ray M, Yu S, Sharda DR, Wilson CB, Liu Q, Kaushal N, Prabhu KS, Hankey PA.

J Immunol. 2010 Dec 15;185(12):7309-16. doi: 10.4049/jimmunol.1000095. Epub 2010 Nov 15.


SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages.

Prêle CM, Woodward EA, Bisley J, Keith-Magee A, Nicholson SE, Hart PH.

J Immunol. 2008 Dec 1;181(11):8018-26.


Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.

Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE.

J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5.


The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF.

Figueroa L, Xiong Y, Song C, Piao W, Vogel SN, Medvedev AE.

J Immunol. 2012 May 1;188(9):4506-15. doi: 10.4049/jimmunol.1200202. Epub 2012 Apr 2.


The RON receptor tyrosine kinase regulates IFN-gamma production and responses in innate immunity.

Wilson CB, Ray M, Lutz M, Sharda D, Xu J, Hankey PA.

J Immunol. 2008 Aug 15;181(4):2303-10.


Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.


Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.

Dobrovolskaia MA, Medvedev AE, Thomas KE, Cuesta N, Toshchakov V, Ren T, Cody MJ, Michalek SM, Rice NR, Vogel SN.

J Immunol. 2003 Jan 1;170(1):508-19.


The scaffold MyD88 acts to couple protein kinase Cepsilon to Toll-like receptors.

Faisal A, Saurin A, Gregory B, Foxwell B, Parker PJ.

J Biol Chem. 2008 Jul 4;283(27):18591-600. doi: 10.1074/jbc.M710330200. Epub 2008 May 5.


Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.

Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X.

Blood. 2007 Aug 1;110(3):962-71. Epub 2007 Mar 29.


Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.


Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase.

Sharda DR, Yu S, Ray M, Squadrito ML, De Palma M, Wynn TA, Morris SM Jr, Hankey PA.

J Immunol. 2011 Sep 1;187(5):2181-92. doi: 10.4049/jimmunol.1003460. Epub 2011 Aug 1.


Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

Yang HT, Papoutsopoulou S, Belich M, Brender C, Janzen J, Gantke T, Handley M, Ley SC.

Mol Cell Biol. 2012 Sep;32(17):3438-51. doi: 10.1128/MCB.00564-12. Epub 2012 Jun 25.


Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.

Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P.

Biochem J. 2017 Mar 15;474(7):1163-1174. doi: 10.1042/BCJ20160992.

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