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Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.

Randell JC, Fan A, Chan C, Francis LI, Heller RC, Galani K, Bell SP.

Mol Cell. 2010 Nov 12;40(3):353-63. doi: 10.1016/j.molcel.2010.10.017.


Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

Ramer MD, Suman ES, Richter H, Stanger K, Spranger M, Bieberstein N, Duncker BP.

J Biol Chem. 2013 May 24;288(21):14926-35. doi: 10.1074/jbc.M112.392910. Epub 2013 Apr 2.


Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation.

Francis LI, Randell JC, Takara TJ, Uchima L, Bell SP.

Genes Dev. 2009 Mar 1;23(5):643-54. doi: 10.1101/gad.1759609.


Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.

Sheu YJ, Kinney JB, Lengronne A, Pasero P, Stillman B.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1899-908. doi: 10.1073/pnas.1404063111. Epub 2014 Apr 16.


Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

Bruck I, Kaplan DL.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11223-8. doi: 10.1073/pnas.1509608112. Epub 2015 Aug 24.


Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.

Bruck I, Kaplan D.

J Biol Chem. 2009 Oct 16;284(42):28823-31. doi: 10.1074/jbc.M109.039123. Epub 2009 Aug 18.


Mcm2 phosphorylation and the response to replicative stress.

Stead BE, Brandl CJ, Sandre MK, Davey MJ.

BMC Genet. 2012 May 7;13:36. doi: 10.1186/1471-2156-13-36.


The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.

Bruck I, Kaplan DL.

J Biol Chem. 2015 Jan 9;290(2):1210-21. doi: 10.1074/jbc.M114.608232. Epub 2014 Dec 3. Retraction in: J Biol Chem. 2017 Jun 16;292(24):10320.


The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4.

Sheu YJ, Stillman B.

Nature. 2010 Jan 7;463(7277):113-7. doi: 10.1038/nature08647.


Structural changes in Mcm5 protein bypass Cdc7-Dbf4 function and reduce replication origin efficiency in Saccharomyces cerevisiae.

Hoang ML, Leon RP, Pessoa-Brandao L, Hunt S, Raghuraman MK, Fangman WL, Brewer BJ, Sclafani RA.

Mol Cell Biol. 2007 Nov;27(21):7594-602. Epub 2007 Aug 27.


Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.

Sheu YJ, Kinney JB, Stillman B.

Genome Res. 2016 Mar;26(3):315-30. doi: 10.1101/gr.195248.115. Epub 2016 Jan 5.


A Positive Amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase.

Bruck I, Dhingra N, Kaplan DL.

J Biol Chem. 2017 Feb 24;292(8):3062-3073. doi: 10.1074/jbc.M116.772368. Epub 2017 Jan 12.


Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage.

Stead BE, Brandl CJ, Davey MJ.

Nucleic Acids Res. 2011 Sep 1;39(16):6998-7008. doi: 10.1093/nar/gkr371. Epub 2011 May 19.


Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation.

Deegan TD, Yeeles JT, Diffley JF.

EMBO J. 2016 May 2;35(9):961-73. doi: 10.15252/embj.201593552. Epub 2016 Feb 24.


Interplay between S-cyclin-dependent kinase and Dbf4-dependent kinase in controlling DNA replication through phosphorylation of yeast Mcm4 N-terminal domain.

Devault A, Gueydon E, Schwob E.

Mol Biol Cell. 2008 May;19(5):2267-77. doi: 10.1091/mbc.E07-06-0614. Epub 2008 Mar 5.


Insights into the Initiation of Eukaryotic DNA Replication.

Bruck I, Perez-Arnaiz P, Colbert MK, Kaplan DL.

Nucleus. 2015;6(6):449-54. doi: 10.1080/19491034.2015.1115938. Epub 2015 Dec 28.


Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation.

Zegerman P, Diffley JF.

Nature. 2010 Sep 23;467(7314):474-8. doi: 10.1038/nature09373. Epub 2010 Sep 12.


Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.

Lei M, Kawasaki Y, Young MR, Kihara M, Sugino A, Tye BK.

Genes Dev. 1997 Dec 15;11(24):3365-74.


Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation.

Nougar├Ęde R, Della Seta F, Zarzov P, Schwob E.

Mol Cell Biol. 2000 Jun;20(11):3795-806.

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