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Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15.

Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Mol Endocrinol. 2010 Dec;24(12):2303-14. doi: 10.1210/me.2010-0260. Epub 2010 Nov 3.


Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6.

Wang Y, Liang N, Yao G, Tian H, Zhai Y, Yin Y, Sun F.

Mol Cell Endocrinol. 2014 Feb 15;382(2):804-13. doi: 10.1016/j.mce.2013.10.031. Epub 2013 Nov 8.


Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.

Su YQ, Sugiura K, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Mol Endocrinol. 2010 Jun;24(6):1230-9. doi: 10.1210/me.2009-0497. Epub 2010 Apr 9.


Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes.

Guo J, Shi L, Gong X, Jiang M, Yin Y, Zhang X, Yin H, Li H, Emori C, Sugiura K, Eppig JJ, Su YQ.

J Cell Sci. 2016 Aug 15;129(16):3091-103. doi: 10.1242/jcs.182642. Epub 2016 Jun 29.


Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells.

Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ.

Development. 2007 Jul;134(14):2593-603. Epub 2007 Jun 6. Erratum in: Development. 2008 Feb;135(4):786.


Role of oocyte-secreted growth differentiation factor 9 in the regulation of mouse cumulus expansion.

Dragovic RA, Ritter LJ, Schulz SJ, Amato F, Armstrong DT, Gilchrist RB.

Endocrinology. 2005 Jun;146(6):2798-806. Epub 2005 Mar 10.


Importance of the GDF9 signaling pathway on cumulus cell expansion and oocyte competency in sheep.

Varnosfaderani ShR, Ostadhosseini S, Hajian M, Hosseini SM, Khashouei EA, Abbasi H, Hosseinnia P, Nasr-Esfahani MH.

Theriogenology. 2013 Sep 15;80(5):470-8. doi: 10.1016/j.theriogenology.2013.05.009. Epub 2013 Jun 10.


Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply.

Sugimura S, Ritter LJ, Sutton-McDowall ML, Mottershead DG, Thompson JG, Gilchrist RB.

Mol Hum Reprod. 2014 Jun;20(6):499-513. doi: 10.1093/molehr/gau013. Epub 2014 Feb 19.


Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans.

Li Y, Li RQ, Ou SB, Zhang NF, Ren L, Wei LN, Zhang QX, Yang DZ.

Reprod Biol Endocrinol. 2014 Aug 20;12:81. doi: 10.1186/1477-7827-12-81.


Effects of growth differentiation factor 9 and bone morphogenetic protein 15 on the in vitro maturation of porcine oocytes.

Lin ZL, Li YH, Xu YN, Wang QL, Namgoong S, Cui XS, Kim NH.

Reprod Domest Anim. 2014 Apr;49(2):219-27. doi: 10.1111/rda.12254. Epub 2013 Dec 9.


Oocytes in sheep homozygous for a mutation in bone morphogenetic protein receptor 1B express lower mRNA levels of bone morphogenetic protein 15 but not growth differentiation factor 9.

Crawford JL, Heath DA, Reader KL, Quirke LD, Hudson NL, Juengel JL, McNatty KP.

Reproduction. 2011 Jul;142(1):53-61. doi: 10.1530/REP-10-0485. Epub 2011 Apr 7.


MicroRNA-224 delays oocyte maturation through targeting Ptx3 in cumulus cells.

Li X, Wang H, Sheng Y, Wang Z.

Mech Dev. 2017 Feb;143:20-25. doi: 10.1016/j.mod.2016.12.004. Epub 2016 Dec 28.


Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells.

Su YQ, Sugiura K, Wigglesworth K, O'Brien MJ, Affourtit JP, Pangas SA, Matzuk MM, Eppig JJ.

Development. 2008 Jan;135(1):111-21. Epub 2007 Nov 28.


Different follicle-stimulating hormone exposure regimens during antral follicle growth alter gene expression in the cumulus-oocyte complex in mice.

Sánchez F, Adriaenssens T, Romero S, Smitz J.

Biol Reprod. 2010 Oct;83(4):514-24. doi: 10.1095/biolreprod.109.083311. Epub 2010 Jun 30.


Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells.

Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Biol Reprod. 2009 Nov;81(5):833-41. doi: 10.1095/biolreprod.109.078485. Epub 2009 Jun 24.


Oocyte expression, secretion and somatic cell interaction of mouse bone morphogenetic protein 15 during the peri-ovulatory period.

Mester B, Ritter LJ, Pitman JL, Bibby AH, Gilchrist RB, McNatty KP, Juengel JL, McIntosh CJ.

Reprod Fertil Dev. 2015 Jun;27(5):801-11. doi: 10.1071/RD13336.


Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality.

Mottershead DG, Sugimura S, Al-Musawi SL, Li JJ, Richani D, White MA, Martin GA, Trotta AP, Ritter LJ, Shi J, Mueller TD, Harrison CA, Gilchrist RB.

J Biol Chem. 2015 Sep 25;290(39):24007-20. doi: 10.1074/jbc.M115.671487. Epub 2015 Aug 8.


Estradiol promotes and maintains cumulus cell expression of natriuretic peptide receptor 2 (NPR2) and meiotic arrest in mouse oocytes in vitro.

Zhang M, Su YQ, Sugiura K, Wigglesworth K, Xia G, Eppig JJ.

Endocrinology. 2011 Nov;152(11):4377-85. doi: 10.1210/en.2011-1118. Epub 2011 Sep 13.

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