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TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway.

Guo R, Meng Q, Guo H, Xiao L, Yang X, Cui Y, Huang Y.

Mol Med Rep. 2016 Feb;13(2):1105-10. doi: 10.3892/mmr.2015.4645.


TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion.

Lamouille S, Connolly E, Smyth JW, Akhurst RJ, Derynck R.

J Cell Sci. 2012 Mar 1;125(Pt 5):1259-73. doi: 10.1242/jcs.095299.


Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.

Wang F, Li H, Yan XG, Zhou ZW, Yi ZG, He ZX, Pan ST, Yang YX, Wang ZZ, Zhang X, Yang T, Qiu JX, Zhou SF.

Drug Des Devel Ther. 2015 Jan 17;9:575-601. doi: 10.2147/DDDT.S75221.


TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition.

Thien A, Prentzell MT, Holzwarth B, Kläsener K, Kuper I, Boehlke C, Sonntag AG, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E, Thedieck K.

Dev Cell. 2015 Mar 9;32(5):617-30. doi: 10.1016/j.devcel.2015.01.026. Erratum in: Dev Cell. 2015 May 4;33(3):366.


Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells.

Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF.

Drug Des Devel Ther. 2015 Jan 17;9:537-60. doi: 10.2147/DDDT.S73689.


Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.

Ding YH, Zhou ZW, Ha CF, Zhang XY, Pan ST, He ZX, Edelman JL, Wang D, Yang YX, Zhang X, Duan W, Yang T, Qiu JX, Zhou SF.

Drug Des Devel Ther. 2015 Jan 9;9:425-64. doi: 10.2147/DDDT.S74062.


Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition.

Tanahashi T, Osada S, Yamada A, Kato J, Yawata K, Mori R, Imai H, Sasaki Y, Saito S, Tanaka Y, Nonaka K, Yoshida K.

Int J Oncol. 2013 Feb;42(2):556-64. doi: 10.3892/ijo.2012.1726.


SchA-p85-FAK complex dictates isoform-specific activation of Akt2 and subsequent PCBP1-mediated post-transcriptional regulation of TGFβ-mediated epithelial to mesenchymal transition in human lung cancer cell line A549.

Xue X, Wang X, Liu Y, Teng G, Wang Y, Zang X, Wang K, Zhang J, Xu Y, Wang J, Pan L.

Tumour Biol. 2014 Aug;35(8):7853-9. doi: 10.1007/s13277-014-1982-1.


Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways.

Chen XF, Zhang HJ, Wang HB, Zhu J, Zhou WY, Zhang H, Zhao MC, Su JM, Gao W, Zhang L, Fei K, Zhang HT, Wang HY.

Mol Biol Rep. 2012 Apr;39(4):3549-56. doi: 10.1007/s11033-011-1128-0.


TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways.

Ha GH, Park JS, Breuer EK.

Cancer Lett. 2013 May 10;332(1):63-73. doi: 10.1016/j.canlet.2013.01.013.


TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway.

Vo BT, Morton D Jr, Komaragiri S, Millena AC, Leath C, Khan SA.

Endocrinology. 2013 May;154(5):1768-79. doi: 10.1210/en.2012-2074.


A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition.

Xu W, Yang Z, Lu N.

Cell Adh Migr. 2015;9(4):317-24. doi: 10.1080/19336918.2015.1016686. Review.


Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis.

Wang H, Zhang H, Tang L, Chen H, Wu C, Zhao M, Yang Y, Chen X, Liu G.

Toxicology. 2013 Jan 7;303:139-46. doi: 10.1016/j.tox.2012.09.017.


TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.

Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A.

Mol Biol Cell. 2005 Apr;16(4):1987-2002.


Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition.

Derynck R, Muthusamy BP, Saeteurn KY.

Curr Opin Cell Biol. 2014 Dec;31:56-66. doi: 10.1016/ Review.

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