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Items: 1 to 20 of 75

1.

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK.

Nat Neurosci. 2010 Dec;13(12):1457-9. doi: 10.1038/nn.2664. Epub 2010 Oct 31.

2.

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK.

J Clin Invest. 2013 Dec;123(12):5061-70. doi: 10.1172/JCI70338. Epub 2013 Nov 1. Erratum in: J Clin Invest. 2014 Apr 1;124(4):1868. Dosage error in article text.

3.

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK.

Neuron. 2011 Aug 11;71(3):488-97. doi: 10.1016/j.neuron.2011.06.012.

4.

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK.

Neuron. 2008 Nov 26;60(4):582-9. doi: 10.1016/j.neuron.2008.09.033.

5.

Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

Roepke TA, Smith AW, Rønnekleiv OK, Kelly MJ.

Am J Physiol Endocrinol Metab. 2012 Jun 1;302(11):E1399-406. doi: 10.1152/ajpendo.00565.2011. Epub 2012 Mar 20.

6.

Serotonin 5-hydroxytryptamine2C receptor signaling in hypothalamic proopiomelanocortin neurons: role in energy homeostasis in females.

Qiu J, Xue C, Bosch MA, Murphy JG, Fan W, Rønnekleiv OK, Kelly MJ.

Mol Pharmacol. 2007 Oct;72(4):885-96. Epub 2007 Jul 10.

7.

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors.

Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK.

Endocrinology. 2008 Mar;149(3):1323-8. Epub 2007 Nov 26.

8.

A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.

Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK.

J Neurosci. 2010 Nov 3;30(44):14630-4. doi: 10.1523/JNEUROSCI.5412-09.2010.

9.

Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons.

Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X.

Cell Metab. 2013 Jul 2;18(1):86-98. doi: 10.1016/j.cmet.2013.06.014.

10.

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

Berglund ED, Vianna CR, Donato J Jr, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK.

J Clin Invest. 2012 Mar;122(3):1000-9. doi: 10.1172/JCI59816. Epub 2012 Feb 13.

11.

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.

Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK.

Cell Metab. 2010 Apr 7;11(4):286-97. doi: 10.1016/j.cmet.2010.03.002.

12.

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055. Epub 2011 Jan 24.

13.

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.

Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ.

Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029. Epub 2015 Apr 9.

14.

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

Könner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Brüning JC.

Cell Metab. 2007 Jun;5(6):438-49.

15.

Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.

Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH.

J Neurosci. 2009 Jun 24;29(25):8156-65. doi: 10.1523/JNEUROSCI.3905-08.2009.

16.
17.

Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons.

Lin HV, Plum L, Ono H, Gutiérrez-Juárez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D.

Diabetes. 2010 Feb;59(2):337-46. doi: 10.2337/db09-1303. Epub 2009 Nov 23.

18.

Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene.

Nonogaki K, Ohba Y, Wakameda M, Tamari T.

Int J Neuropsychopharmacol. 2009 May;12(4):547-52. doi: 10.1017/S1461145708009619. Epub 2008 Oct 31.

PMID:
18976545
19.

Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus.

Arai T, Maejima Y, Muroya S, Yada T.

Neuropeptides. 2013 Aug;47(4):225-30. doi: 10.1016/j.npep.2013.05.004. Epub 2013 Jun 10.

PMID:
23756052
20.

Serotonin 5-HT(2C) receptors regulate anxiety-like behavior.

Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH.

Genes Brain Behav. 2007 Jul;6(5):491-6. Epub 2007 Apr 19.

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