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Items: 1 to 20 of 143

1.

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

Klein RC, Mace BE, Moore SD, Sullivan PM.

Neuroscience. 2010 Dec 29;171(4):1265-72. doi: 10.1016/j.neuroscience.2010.10.027. Epub 2010 Oct 15.

2.

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.

Klein RC, Acheson SK, Mace BE, Sullivan PM, Moore SD.

Neurobiol Aging. 2014 Sep;35(9):2046-52. doi: 10.1016/j.neurobiolaging.2014.02.019. Epub 2014 Mar 2.

3.
4.

ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

Dumanis SB, Tesoriero JA, Babus LW, Nguyen MT, Trotter JH, Ladu MJ, Weeber EJ, Turner RS, Xu B, Rebeck GW, Hoe HS.

J Neurosci. 2009 Dec 2;29(48):15317-22. doi: 10.1523/JNEUROSCI.4026-09.2009.

5.

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex.

Arold S, Sullivan P, Bilousova T, Teng E, Miller CA, Poon WW, Vinters HV, Cornwell LB, Saing T, Cole GM, Gylys KH.

Acta Neuropathol. 2012 Jan;123(1):39-52. doi: 10.1007/s00401-011-0892-1. Epub 2011 Oct 22.

6.

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.

Bour A, Grootendorst J, Vogel E, Kelche C, Dodart JC, Bales K, Moreau PH, Sullivan PM, Mathis C.

Behav Brain Res. 2008 Nov 21;193(2):174-82. doi: 10.1016/j.bbr.2008.05.008. Epub 2008 May 18.

PMID:
18572260
7.

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.

Wang C, Wilson WA, Moore SD, Mace BE, Maeda N, Schmechel DE, Sullivan PM.

Neurobiol Dis. 2005 Mar;18(2):390-8.

PMID:
15686968
8.

ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro.

Nwabuisi-Heath E, Rebeck GW, Ladu MJ, Yu C.

ASN Neuro. 2014 Jan 13;6(1):e00134. doi: 10.1042/AN20130043.

9.
10.

APOE genotype alters glial activation and loss of synaptic markers in mice.

Zhu Y, Nwabuisi-Heath E, Dumanis SB, Tai LM, Yu C, Rebeck GW, LaDu MJ.

Glia. 2012 Apr;60(4):559-69. doi: 10.1002/glia.22289. Epub 2012 Jan 6.

11.

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV.

Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087.

12.
13.

Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice.

Klein RC, Saini S, Risher ML, Acheson SK, Fleming RL, Sexton HG, Swartzwelder HS, Moore SD.

PLoS One. 2014 Apr 14;9(4):e94071. doi: 10.1371/journal.pone.0094071. eCollection 2014.

14.

Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.

Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM.

Brain Res. 2012 Jul 27;1467:120-32. doi: 10.1016/j.brainres.2012.05.048. Epub 2012 Jun 5.

PMID:
22682924
15.

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

Johnson LA, Olsen RH, Merkens LS, DeBarber A, Steiner RD, Sullivan PM, Maeda N, Raber J.

Neurobiol Dis. 2014 Apr;64:150-62. doi: 10.1016/j.nbd.2013.12.016. Epub 2014 Jan 9.

16.

Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.

Pankiewicz JE, Guridi M, Kim J, Asuni AA, Sanchez S, Sullivan PM, Holtzman DM, Sadowski MJ.

Acta Neuropathol Commun. 2014 Jun 28;2:75. doi: 10.1186/s40478-014-0075-0.

17.

Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.

Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y.

PLoS One. 2012;7(12):e53569. doi: 10.1371/journal.pone.0053569. Epub 2012 Dec 31.

18.

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.

Grootendorst J, Bour A, Vogel E, Kelche C, Sullivan PM, Dodart JC, Bales K, Mathis C.

Behav Brain Res. 2005 Apr 15;159(1):1-14. Epub 2004 Nov 6.

PMID:
15794991
19.

Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.

Vandal M, Alata W, Tremblay C, Rioux-Perreault C, Salem N Jr, Calon F, Plourde M.

J Neurochem. 2014 May;129(3):516-26. doi: 10.1111/jnc.12640. Epub 2014 Jan 29.

20.

Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice.

Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L.

Am J Pathol. 2010 Aug;177(2):563-9. doi: 10.2353/ajpath.2010.090973. Epub 2010 Jul 1.

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