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Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway.

Vohra BP, Sasaki Y, Miller BR, Chang J, DiAntonio A, Milbrandt J.

J Neurosci. 2010 Oct 13;30(41):13729-38. doi: 10.1523/JNEUROSCI.2939-10.2010.


Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG.

Hum Mol Genet. 2013 Apr 15;22(8):1601-14. doi: 10.1093/hmg/ddt009. Epub 2013 Jan 11.


APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.

Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.

Nature. 2009 Feb 19;457(7232):981-9. doi: 10.1038/nature07767.


Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons.

Sasaki Y, Milbrandt J.

J Biol Chem. 2010 Dec 31;285(53):41211-5. doi: 10.1074/jbc.C110.193904. Epub 2010 Nov 11.


Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons.

Wang Y, Zhao D, Pan B, Song Z, Shah SZ, Yin X, Zhou X, Yang L.

J Mol Neurosci. 2015 Aug;56(4):966-76. doi: 10.1007/s12031-015-0562-1. Epub 2015 Apr 22.


Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin.

Yang J, Weimer RM, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, Tessier-Lavigne M.

Neuron. 2013 Dec 4;80(5):1175-89. doi: 10.1016/j.neuron.2013.08.034. Epub 2013 Nov 7.


Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.

Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M.

J Neurosci. 2014 May 7;34(19):6438-47. doi: 10.1523/JNEUROSCI.3522-13.2014.


Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo.

Sasaki Y, Vohra BP, Baloh RH, Milbrandt J.

J Neurosci. 2009 May 20;29(20):6526-34. doi: 10.1523/JNEUROSCI.1429-09.2009.


Sarm1-mediated axon degeneration requires both SAM and TIR interactions.

Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J.

J Neurosci. 2013 Aug 14;33(33):13569-80. doi: 10.1523/JNEUROSCI.1197-13.2013.


Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.

Press C, Milbrandt J.

J Neurosci. 2008 May 7;28(19):4861-71. doi: 10.1523/JNEUROSCI.0525-08.2008.


The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A.

Cell Rep. 2013 May 30;3(5):1422-9. doi: 10.1016/j.celrep.2013.04.013. Epub 2013 May 9.


Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Abeta in distal axons.

Song MS, Saavedra L, de Chaves EI.

Neurobiol Aging. 2006 Sep;27(9):1224-38. Epub 2005 Aug 24.


Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss.

Calixto A, Jara JS, Court FA.

PLoS Genet. 2012;8(12):e1003141. doi: 10.1371/journal.pgen.1003141. Epub 2012 Dec 27.


A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity.

Fang Y, Soares L, Teng X, Geary M, Bonini NM.

Curr Biol. 2012 Apr 10;22(7):590-5. doi: 10.1016/j.cub.2012.01.065. Epub 2012 Mar 15.


Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.

Araki T, Sasaki Y, Milbrandt J.

Science. 2004 Aug 13;305(5686):1010-3.


Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

Yahata N, Yuasa S, Araki T.

J Neurosci. 2009 May 13;29(19):6276-84. doi: 10.1523/JNEUROSCI.4304-08.2009.


Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC.

Neuron. 2006 Jul 6;51(1):29-42.


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